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burlyman30
11-12-2012, 01:12 AM
Mesterolone and it's effects on Testosterone, LH, and FSH levels


Varma TR, Patel RH.

Department of Obstetrics & Gynaecology, St. George's Hospital Medical School London, U.K.

Two hundred fifty subfertile men with idiopathic oligospermia (count less than 20 million/ml) were treated with mesterolone (100-150 mg/day) for 12 months. Seminal analysis were assa 3 times and serum follicle stimulating hormone (FSH - follicle stimulating hormone - ) luteinizing hormone (lh - leutenizing hormone - ) and plasma testosterone were assa once before treatment and repeated at 3, 6, 9 and 12 months after the initiation of treatment. One hundred ten patients (44%) had normal serum FSH - follicle stimulating hormone - , lh - leutenizing hormone - and plasma testosterone, 85 patients (34%) had low serum FSH - follicle stimulating hormone - , lh - leutenizing hormone - and low plasma testosterone. One hundred seventy-five patients (70%) had moderate oligospermia (count 5 to less than 20 million/ml) and 75 patients (30%) had severe oligospermia (count less than 5 million/ml). Seventy-five moderately oligospermic patients showed significant improvement in the sperm density, total sperm count and motility following mesterolone therapy whereas only 12% showed improvement in the severe oligospermic group. Mesterolone had no depressing effect on low or normal serum FSH - follicle stimulating hormone - and lh - leutenizing hormone - levels but had depressing effect on 25% if the levels were elevated. There was no significant adverse effect on testosterone levels or on Liver function. One hundred fifteen (46%) pregnancies resulted following the treatment, 9 of 115 (7.8%) aborted and 2 (1.7%) had ectopic pregnancy. Mesterolone was found to be more useful in patients with a sperm count ranging between 5 and 20 million/ml. Those with severe oligospermia (count less than 5 million) do not seem to benefit from this therapy.

The effect of mesterolone on sperm cou... [Int J Gynaecol Obstet. 1988] - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/2892728)