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burlyman30
11-16-2012, 12:38 AM
Anabolic steroids impair the exercise-induced growth of the cardiac capillary bed.


Tagarakis CV, Bloch W, Hartmann G, Hollmann W, Addicks K.

Source
Institute I of Anatomy, University of Cologne, Germany.

Abstract

BACKGROUND:
Concomitant application of anabolic-androgenic steroids and physical exercise can induce cardiac hypertrophy. These experiments investigate the still unknown response of the cardiac myocytes and capillaries to the combined influence of various anabolic steroids and muscular exercise.

METHODS:
Female SPF-NMRI mice were divided into the following groups: a) sedentary control, b) exercise (treadmill running); c) sedentary receiving Dianabol; d) exercise + Dianabol; e) exercise + Oral-Turinabol. After 3 and 6 weeks the left ventricular papillary muscles were studied morphometrically. Evaluated variables: minimal myocyte diameter, number of capillaries around a single myocyte, capillary density and intercapillary distance.

RESULTS:
Only the anabolic steroids + exercise groups showed a mild myocyte hypertrophy. In contrast, only exercise alone caused a significant increase of the capillary density after both experimental periods; e.g. capillary density after 6 weeks (capillaries/mm2, mean values +/- standard deviation, p < 0.05): control (4,272 +/- 287), exercise (5411 +/- 755), dianabol (4,004 +/- 333), dianabol + exercise (4,076 +/- 403), oral-turinabol + exercise (4,053 +/- 306). Moreover, unlike all other regimens, only exercise alone shortened the intercapillary distance. Finally, exercise without drugs induced the greatest increase in the number of capillaries around a single myocyte.

CONCLUSIONS:
Anabolic steroids combined with exercise: 1) induce mild hypertrophy of the cardiac myocytes, 2) impair the cardiac microvascular adaptation to physical conditioning. The microvascular impairment may cause a detrimental alteration of the myocardial oxygen supply, especially during muscular exercise.

Anabolic steroids impair the exercise-induc... [Int J Sports Med. 2000] - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/10961516)

DJM
11-16-2012, 07:10 AM
Intratesticular leiomyosarcoma in a young man after high dose doping with Oral-Turinabol: a case report.


Cancer. 1999 Oct 15;86(8):1571-5.
Intratesticular leiomyosarcoma in a young man after high dose doping with Oral-Turinabol: a case report.
Froehner M, Fischer R, Leike S, Hakenberg OW, Noack B, Wirth MP.
Source

Department of Urology, Universitaetsklinikum "Carl Gustav Carus," Technical University of Dresden, Dresden, Germany.
Abstract
BACKGROUND:

Androgenic anabolic steroids have been suspected of activity as carcinogens in the development of carcinoma and angiosarcoma of the liver and adenocarcinoma of the prostate. Although the proliferation of smooth muscle cells is stimulated by sexual steroids, to the authors' knowledge a possible relation between androgenic anabolic steroids and the development of leiomyosarcoma has not previously been reported in humans.
METHODS:

A 32-year-old man underwent right radical orchiectomy for a tumor of the upper pole of the right testicle. Routine histopathologic examination and immunohistochemical staining were performed.
RESULTS:

The tumor was identified as an intratesticular leiomyosarcoma based on its typical growth pattern and the characteristic immunohistochemical staining profile. The patient reported a 5-year history of systematic use of high dose Oral-Turinabol (4-chloro-1-dehydro-17alpha-methylteststerone) that began at age 18 years and stopped approximately 9 years before presentation.
CONCLUSIONS:

The rarity of intratesticular leiomyosarcoma, the experimental induction of similar tumors in animals by androgens and estrogens, and the unusually young age at presentation of the patient in the current study support the hypothesis that high dose doping with androgenic anabolic steroids could have played a cocarcinogenic role in the development of the tumor in this case.

Intratesticular leiomyosarcoma in a young man after h... [Cancer. 1999] - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/10526287)