View Full Version : Archive of Steroid Profiles by Eric Potratz
The following posts represent steroid profiles originally released by Eric Potratz for Primordial Performance.
©Eric Potratz, All Rights Reserved.
Printed with Permission.
Chemical Name(s):
2,17a-Dimethyl-17b-hydroxy-5a-androst-1-en-3-one
Chemical Formula:
C21H32O2
Molecular Weight:
316.5
CAS:
NA
Q Qatio:
3.9
Anabolic #:
660
Androgenic #:
170
Oral Bioavailability:
Estimated at 50%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
NA
Legal Status (US):
Not listed as a controlled substance
Average Dose:
5-20mg/day standalone
1-5mg/day when stacked
Average Cycle Length:
2-4 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +5
Strength Gain: +5
Fat Gain (Negative Indicates Fat loss): -1
Water Retention: +2
Aggression: +4
Libido: 0
Acne: 0
Hair Loss: +3
Prostate Enlargement: +3
Liver Toxicity: +5
Lethargy +1
Characteristics
Although this compound cannot convert to estrogen, it will bind strongly to SHBG, thus increasing freely circulating estrogen (and testosterone). While there is a lack of anecdotal feedback from this compound to tell the real world effect this compound may have on causing gyno, experience with related compounds tell us gyno symptoms may occur.
Users should be very careful with methylstenbolone and start out with a very low dose. This compound will likely produce a rapid increase in intracellular water retention by inhibiting 11-beta hydroxylase and building up levels of mineralcorticoids that will encourage sodium and water retention.
Gains upwards of 20-25lbs in 4 weeks are probably possible with this compound. However the liver toxicity issues would likely be the first reason why someone wouldn’t be able to make incredible gains from this compound. For this reason it would be extremely important to pre-condition the liver with a liver protecting supplement prior to cycling this compound, while continuing use throughout the cycle and during PCT.
The strength increases from this compound will likely encourage weight lifting heavier than tendons and joints are prepared to lift. It is recommended to be cautious of this and to naturally build up strength levels prior to cycling this steroid.
Using a low dose of methylstenbolone with a moderate dose of a non-methylated compound would be an acceptable way to try to limit the side-effects from this compound, although caution would still need to be taken for liver health no matter what dose is used.
Because of the strength and weight gain this compound would offer it would likely be best used as part of a bulking cycle.
References
Anabolic Pharmacology
Seth Roberts (2009)
Chemical Name(s):
Androsta-1,4,6-triene-3,17-dione
1,4,6-androstatriene-3,17-dione
Chemical Formula:
C19H22O2
Molecular Weight:
282
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 4%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
2 days
Legal Status (US):
Not listed as a controlled substance
Average Dose:
25-100mg/day
Average Cycle Length:
4-8 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: 0
Strength Gain: 0
Fat Gain (Negative Indicates Fat loss): 0
Water Retention: 0
Aggression: 0
Libido: -2
Acne: 0
Hair Loss: 0
Prostate Enlargement: 0
Liver Toxicity: 0
Lethargy 0
Characteristics
ATD is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme.
ATD is used for its aromatase inhibiting and testosterone boosting effect. Its effectiveness at lowering estrogen appears to be stronger than 6-oxo. It converts to 1,4,6-testosterone, which would also be expected to cause falsely high readings for a testosterone analysis.
The 1,4,6-testosterone metabolite of ATD can also bind to the androgen receptor (AR) and induce androgenic (or possibly anti-androgenic) effects similar to what is seen from 6-oxo. This would be expected since 1,4,6-testosterone has about one third the binding affinity for the AR, therefore it may interefere with the anabolic or androgenic action of hormones which bind the androgen receptor.
ATD would also be expected to interfere with production of natural testosterone by acting upon the hypothalamus pituitary testicular axis (HPTA), therefore this compound should not be used during post cycle therapy (PCT), however it could successfully be used during a cycle to help keep estrogen in control. Anecdotal reports and animal studies have also shown ATD inhibits libido and general sexual potency.
Common Clones:
Arom-X by Advanced Muscle Science (AMS)
AIFM by Anafit
ATD MAX by Anabolic Formulations
ATD-JET by Molecular Developments
Reversitol by IForce
References
Effect of an inhibitor of aromatization, 1,4,6 androstatriene-3,17-dione (ATD) on LH release and steroid binding in hypothalamus of adult female rats.
Exp Brain Res. 1986;64(3):407-10.
Slama A, Gogan F, Sarrieau A, Vial M, Rostene W, Kordon C.
Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis.
ME Kaplan and MY McGinnis
Horm Behav, Mar 1989; 23(1): 10-26.
Anabolic Pharmacology
Seth Roberts (2009)
Chemical Name(s):
2-cyano-17a-methyl-17b-hydroxy-androstan-3-one
2-cyano-17a-methyl-17b-hydroxy-androst-3-one (incorrect name)
Chemical Formula:
C21H31NO2
Molecular Weight:
329
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 40%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
NA
Legal Status (US):
Not listed as a controlled substance
Average Dose:
40-50mg/day standalone
20-30mg/day when stacking
Average Cycle Length:
4-6 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +1
Strength Gain: +2
Fat Gain (Negative Indicates Fat loss): 0
Water Retention: 0
Aggression: +1
Libido: +1
Acne: 0
Hair Loss: +1
Prostate Enlargement: +1
Liver Toxicity: +2
Lethargy +1
Characteristics
2-cyano-dromostolone is a 17aa molecule relatively new to the scene with very few reviews as of yet.
It has a cyano group attached to the 2 position. The chemical structure is the same as methyldrostanolone (Superdrol), except it has a CN group on the 2 position instead of a methyl group. It is a C-17aa steroid and it will be liver toxic. Although, due to the lack of the 4-ene on ring A and lack of 2-methylation, liver toxicity may be reduced relative to a di-methylated steroid such as Superdrol.
So far, feedback is very limited for this compound. However results would be expected to be fairly lean as this compound cannot convert to estrogen. Based on the chemical structure the anabolic potency would appear to be fairly potent with moderate androgenic potency.
At the time of this writing there was only one manufacturer to bring this product to the market and there seems to have been a nomenclature mistake on the labeling for this steroid. The chemical name contains the term “androst”, assuming that there is some sort of ene group on ring A. But there does not seem to be such mention of an ene group on ring A. Therefore, the term androst should be androstan. But if this is the case, the 2-cyano group needs to be stated as alpha or beta. This makes a big difference, since usually C2-alpha groups are significantly more effective than beta.
There are studies about other 2-cyano steroids such as 2-cyano-DHT and 2-cyano-progesterone. In separate studies, one done on dogs, it was seen that both of these 2-cyano steroids caused inhibition of 3b-HSD enzyme. This inhibition would cause severe adrenal suppression. This is a very unsafe inhibition. Whether it occurs in this cyano steroid is unknown, but users need to be aware of this possibility.
Common Clones:
Cynostane by Anabolic Innovation
References
Anabolic Pharmacology
Seth Roberts (2009)
Chemical Name(s):
4-androsten-3,6,17-trione
3,6,17-androstenetrione
androst-4-ene-3,6,17-trione
6-ketoandrostenedione
Chemical Formula:
C19H24O3
Molecular Weight:
300
CAS:
NA
Q Qatio: [/B
]NA
[B]Anabolic #:
NA
Androgenic #: [/B
]NA
[B]Oral Bioavailability:
Estimated at 4%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
3-6 hours
Legal Status (US):
Not listed as a controlled substance
Average Dose:
300-600mg/day
Average Cycle Length:
4-8 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: 0
Strength Gain: 0
Fat Gain (Negative Indicates Fat loss): 0
Water Retention: 0
Aggression: 0
Libido: -1
Acne: +1
Hair Loss: 0
Prostate Enlargement: +1
Liver Toxicity: 0
Lethargy 0
Characteristics
6-OXO is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme.
It is used for its anti-estrogen and testosterone boosting effects.
There is debate about whether or not 6-oxo actually lowers estrogen or increases testosterone. Several human studies have shown an increase in estrone levels following 6-oxo supplementation. However, one of the primary metabolites of 6-oxo is 6-oxoestrone which may have given a false positive for elevated estrone levels. The human study also concluded that 6-oxo raised testosterone levels, however it is possible that 6-oxotestosterone (which is another metabolite of 6-oxo) gave a false positive for the testosterone level as well.
Another interesting element to these articles is that despite the supposed increase in testosterone (enough to cause significant improvements in body composition if given via injection) no improvements where found for fat free mass (FFM) or strength. Therefore, 6-oxo is either a weak AI that doesn’t really inhibit estrogen at the recommended dose and simply converts to metabolites which give false readings, or it actually does increase testosterone, while the 6-oxo metabolites antagonize the androgen receptor enough to block any anabolic effect from testosterone.
Either way, no ergonomic or real world benefit could be found after 6-oxo supplementation.
Its also worth mentioning that 6-oxo should never be used post cycle, as its steroidial effects would likely interfere with recovery of natural testosterone production.
References
Immunological interference of the synthetic aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD) and its metabolite(s) in the radioimmunoassay for testosterone.
MD Donaldson and MG Forest
Steroids, Dec 1980; 36(6): 717-21
Testosterone dose-response relationships in healthy young men
Shalender Bhasin, et al.
Am J Physiol Endocrinol Metab, Dec 2001; 281: E1172 – E1181.
Chemical Name(s):
1-androsten-3b-ol-17-one
1-Dehydroepiandrosterone
Chemical Formula:
C19H28O2
Molecular Weight:
NA
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 8%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
NA
Legal Status (US):
Not listed as a controlled substance
Average Dose:
200-300mg/day Transdermally
400-600mg/day standalone (oral)
200-400mg/day when stacking (oral)
Average Cycle Length:
4-6 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +2
Strength Gain: +2
Fat Gain (Negative Indicates Fat loss): 0
Water Retention: 0
Aggression: 0
Libido: -2
Acne: +1
Hair Loss: +1
Prostate Enlargement: 0
Liver Toxicity: 0
Lethargy +3
Characteristics
1- Androsteronetm (1-DHEA) is a non-methylated (non 17aa) pro-steroid that must convert to 1-androstenediol (1-AD), 1-androstenedione (original 1-AD) and/or 1-testosterone to be active. The double bond in the 1st position seems to slightly enhance its ability to resist excretion by the liver.
1-Androsterone occurs naturally in the body, and is a naturally occurring metabolite of DHEA. (2) The 17b-HSD enzyme converts 1-Androsterone to 1-Androstenediol, and the 3b-HSD converts it to 1-Androstenedione. Both of these 1-AD metabolites can then be converted to 1-Testosterone. Although the 1-AD metabolites are known to have some anabolic and androgenic effects on their own, 1-Testosterone is probably where most of the effects come from with this steroid.
There is no conversion to estrogen so users will not experience bloat with this compound, nor will it have a dramatic effect on blood pressure. However one unique side effect that users have reported with this compound is a feeling of lethargy. (It appears that stacking 1-Androsterone with a nuero-active hormone such as DHEA can help reverse this effect)
1-Androsterone (and primarily its metabolites) have relatively potent androgenic effects, therefore gyno is almost never an issue. However, because of the androgenic potency, this compound could pose a mild hair loss risk for those prone to MPB. Because this steroid is non-17aa there should be less concern about it negatively affecting the HDL/LDL ratio.
Results from this compound generally take a couple weeks to be realized. Moderate gains of lean muscle mass and strength can be expected, but users should not expect rapid increases in size or weight with this compound since extra-cellular and intra-cellular water retention are very minimal. This makes the gains from this steroid fairly easy to maintain post cycle.
1-Androsterone will stack well with almost any compound. For more dramatic gains in size and strength it is recommended to stack this compound with an aromatizing steroid or possibly one of the progestational compounds listed elsewhere.
Common Clones:
1-T by Primordial Performance
1-Androsterone by Advanced Muscle Science (AMS)
References
1. 17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties.
A Friedel, et al.
Toxicol Lett, Aug 2006; 165(2): 149-55.
2. “Metabolism of 1-Dehydroandrostanes in Man”
Galletti and Gardi, et al.
J Steroid Biochem, 3 (1972), 933-936
Chemical Name(s):
6-methyleneandrosta-1,4-dien-3,17-dione
Chemical Formula:
C20H24O2
Molecular Weight:
296
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 15%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
27 hours
Legal Status (US):
Prescription only
Average Dose:
10-25mg/day
Average Cycle Length:
4-8 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: 0
Strength Gain: 0
Fat Gain (Negative Indicates Fat loss): -1
Water Retention: -1
Aggression: 0
Libido: -1
Acne: 1
Hair Loss: 0
Prostate Enlargement: 0
Liver Toxicity: 0
Lethargy 0
Characteristics
Exemestane is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme.
Exemestane is one of the most potent and expensive steroidal aromatase inhibitors currently available on the market. It is available by prescription only. The estrogen inhibition rate for exemestane varies from 85% of estradiol to 95% for estrone.
Exemestane is looked highly upon due to the fact it can be just as effective as Letrozole or Arimidex without causing such a rapid rebound of estrogen, which is a typical problem of non-suicidal aromatase inhibitors.
Exemstane is rarely dosed beyond 25mg/day as this appears to be a high enough dose to suppress estrogen by a significant amount. It can reach maximum estrogen suppression in as little as 7 days. Since it increases testosterone levels, some users may experience androgenic effects.
References
Anabolic Pharmacology
Seth Roberts (2009)
Chemical Name(s):
1,4-androstadiene-3b,17b-dione
androst-1,4-diene-3b,17b-dione
1,4-Androstenedione
Chemical Formula:
C19H24O2
Molecular Weight:
284.4
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 8%
AR Binding Affinity:
NA
SHBG Binding Affinity:
Low
Half Life:
NA
Legal Status (US):
Listed as a controlled substance
Average Dose:
800-1500mg/day standalone
400-1000mg/day when stacking
Average Cycle Length:
6 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +2
Strength Gain: +2
Fat Gain (Negative Indicates Fat loss): 0
Water Retention: +1
Aggression: 0
Libido: 0
Acne: +1
Hair Loss: 0
Prostate Enlargement: +1
Liver Toxicity: 0
Lethargy 0
Characteristics
Boldione is NOT a 17-alpha alkylated steroid, therefore high doses must be taken to accommodate for its rapid excretion from the liver.
Boldione itself likely does not have any significant anabolic or androgenic value. However after interaction with the 17b-HSD enzyme, boldione is converted to the illegal anabolic steroid boldenone. Boldione can also be converted to 1-androstenedione (1-AD) and/or 1-testosterone after interaction with the 5a-reductase enzyme. These metabolites are where this pro-hormone gets most of its effects.
Since boldione is a dione, conversions to the more powerful steroid metabolites are expected to be near 15-20%, which is another reason why such high doses are needed to see results.
This pro-hormone (and its metabolites) do not convert very readily to estrogen, so an aromatase inhibitor would likely not be needed during a cycle.
Results can be expected to kick in slowly after several weeks. Moderate gains in size and strength should be expected. This compound also has a tendency to increase appetite, which makes it a good choice for bulking.
Side effects are minimal with boldione, but can become more noticeable with doses above 1000mg/day. Side-effects may include increases blood pressure and oily skin. Overall, results and side-effects would be similar to that of boldenone, including lean mass gains with low bloating. Because this steroid is non-17aa there should be less concern about it negatively affecting the HDL/LDL ratio.
Although this compound can be used as a standalone, it is recommended to stack this compound with an already active steroid, as the high doses of boldione will likely saturate most of the steroid conversion enzymes.
Common Clones:
BOLD by IForce
EQ-Plex by Competitive Edge Labs (CEL)
BOLD 200 by IForce
EQ-Jet by Molecular Development
P-Bold by Proven Products
References
“Criteria to distinguish between natural situations and illegal use of boldenone, boldenone esters and boldione in cattle: 1. Metabolite profiles of boldenone, boldenone esters and boldione in cattle urine.”
Bruno Le Bizec, Frédérique Courant, Isabelle Gaudin, Emanuelle Bichon, Blandine Destrez,
Robert Schilt, Rosa Draisci, Fabrice Monteau and François André
Steroids; Volume 71, Issues 13-14, December 2006, Pages 1078-1087
"An in vitro study on metabolism of 17β-boldenone and boldione using cattle liver and kidney subcellular fractions”
R. Merlanti, G. Gallina, F. Capolongo, L. Contiero, G. Biancotto, M. Dacasto and C. Montesissa
“Pathology of the testicle and sex accessory glands following the administration of boldenone and boldione as growth promoters in veal calves”
Cannizzo, F.T.(Universita degli Studi di Torino (Italy)); Zancanaro, G.; Spada, F.; Mulasso, C.; Biolatti
Nov 2007 Veterinary science and hygiene
Chemical Name(s):
13-ethyl-3-methoxy-gona-2,5(10)-diene-17-one
13b-ethyl-3-methoxy-2,5 (10)-gona-diene-17-one
Chemical Formula:
C20H28O2
Molecular Weight:
300
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 20%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
NA
Legal Status (US):
Not listed as a controlled substance
Average Dose:
50-75mg/day standalone
25-50mg/day when stacked
Average Cycle Length:
4 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +3
Strength Gain: +2
Fat Gain (Negative Indicates Fat loss): +2
Water Retention: +3
Aggression: +1
Libido: +2
Acne: +1
Hair Loss: 0
Prostate Enlargement: 0
Liver Toxicity: +1
Lethargy +1
Characteristics
Methoxygonadiene is not a 17aa steroid so liver toxicity is not as harsh as with 17aa steorids, however the ethyl group on C-18 may make it slightly more toxic than a non-ethylated steroid (while increasing its oral bio-availability). The progestational activity of methoxygonadiene (once it is converted to its active metabolites) is considered to be slightly stronger than nandrolone.
In the stomach acid, the C-3 methoxy group is rapidly cleaved off and the double bond on the A ring at C-2 is lost. At this point, a 3-oxo is formed and a metabolite known as 13b-ethyl-nor-androstenedione is created, which is chemically similar to norbolethone, and probably where this compound gets most of its effects.
13b-ethyl-nor-androstenedione is about equal to testosterone in anabolic potency, yet less androgenic. This would make this compound fairly light on the hairline with minimal chance of acne or other androgenic side-effects.
With low androgenic activity, this compound may negatively affect the libido and erectile function. The lack of androgenic potency and progestational effects make this compound likely to cause gyno symptoms. Users could stack this compound with testosterone or one of its non-aromatizing metabolites to preserve DHT levels and possibly prevent these side-effects.
Users experience rapid weight gain from this compound partly due to subcutaneous water retention from the progestational activity. Therefore the overall gains from this compound may lead to a bloated appearance. Because of the progestational effects, users should avoid stacking this compound with other gyno aggravating compounds. Methoxygonadiene can aromatize to estrogen in small amounts, however not to any significant degree, therefore an aromatase inhibitor would provide little protection against this compounds side-effects.
Common Clones:
Revolt by KiloSports
M-LMG by Competitive Edge Labs (CEL)
X-MASS by Generic Labs
Deiselbolan by Mrsupps
References
Anabolic Pharmacology
Seth Roberts (2009)
Chemical Name(s):
[3,2-c]pyrazole-5alpha-etioallocholane-17b-tetrahydropyranol
Chemical Formula:
C25H38N2O2
Molecular Weight: 3
99
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 15%
AR Binding Affinity:
NA
SHBG Binding Affinity:
Medium
Half Life:
4-6 hours
Legal Status (US):
Not listed as a controlled substance
Average Dose:
200-300mg/day standalone
100-200mg/day when stacked
Average Cycle Length:
4-6 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +2
Strength Gain: +2
Fat Gain (Negative Indicates Fat loss): -1
Water Retention: -1
Aggression: 0
Libido: 0
Acne: 1
Hair Loss: +2
Prostate Enlargement: +1
Liver Toxicity: +1
Lethargy +1
Characteristics
Stanozolol THP is the same compound as the illegal anabolic steroid stanozolol (Winstrol) except it is not 17aa methylated, and instead has a THP ether attached on the 17b position.
The conversion rate for this compound is very low, expected to be less than 15%. Knowing this, users are better off taking doses in the 150-250mg range. The downfall to this is the high cost.
Stanozolol THP does not aromatize and also has very minimal bloat. It has a moderately potent androgenic activity, giving it a fairly low risk for gyno or negative effects on the libido. However its androgenic effects may pose a problem for users prone to androgenic related hair loss.
Once the Stanozolol THP reaches the stomach, most of the THP-ether is probably removed by the stomach acid to form stanozolol (the non-methylated version). Therefore, topical delivery of this compound is probably not worthwhile.
Overall this compound produces mild gains, but the side-effects are very mild too. Noticeable gains in lean muscle mass and strength are not likely going to be achieved unless doses of at least 200mg/day are used. Stanozolol THP is going to produce very little water retention, therefore it should produce a lean and vascular appearance. Big increases in weight are not likely to happen with this steroid either, so increased blood pressure and painful back pumps should not be a problem.
This compound would work well for cutting cycles and would stack well almost any other steroid depending on the goals.
Common Clones:
WinZstrol by Juggarnaught Nutrition
Prostanzonol by Juggarnaught Nutrition
Prostanozol by Generic Labs
Prostanozol by Anabolic Xtreme
P-Stanz by Competitive Edge Labs (CEL)
Orastan-E by Gaspari Nutrition
References
“Metabolism and excretion of anabolic steroids in doping control—New steroids and new insights”
Peter Van Eenoo and Frans T. Delbeke
The Journal of Steroid Biochemistry and Molecular Biology; Volume 101, Issues 4-5, November
2006, Pages 161-178
Chemical Name(s):
2a,3a-epithio-17a-methyl-etioallocholan-17b-ol
2a,3a-epithio-17a-methyl-5a-androstan-17b-ol
Chemical Formula:
C20H30OS
Molecular Weight:
320.5
CAS:
NA
Q Qatio:
12
Anabolic #:
1,100
Androgenic #:
91
Oral Bioavailability:
Estimated at 40%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
~6 hours
Legal Status (US):
Not listed as a controlled substance
Average Dose:
40-50mg/day standalone
10-20mg/day when stacked
Average Cycle Length:
4-6 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +3
Strength Gain: +3
Fat Gain (Negative Indicates Fat loss): -2
Water Retention: -2
Aggression: +1
Libido: -2
Acne: +1
Hair Loss: +2
Prostate Enlargement: +2
Liver Toxicity: +3
Lethargy +1
Characteristics
Methylepitiostanol is a methylated version of the steroid Epitiostanol. It is readily active and does not require conversion. Under the influence of heat methylepitiostanol readily breaks down to 17a-Methyl-androstan-2-en-17b-ol (DMT), a now illegal anabolic steroid.
It does not aromatize, however it is possible that methylepitiostanol may offset estrogen and testosterone from SHBG thus increase the risk of gyno for certain individuals with high SHBG levels. Gyno symptoms from this compound may also be a result of this compounds inability to form a potent androgen such as DHT (to antagonize the effects of estrogen). However, in other cases methylepitiostanol can be used to prevent or reduce gynecomastia from an estrogenic steroid by acting as an aromatase inhibitor to keep estrogen down.
It is a DHT derivative with a fairly moderate androgenic value so the chances of hair loss may be increased in certain sensitive users. Swelling of the prostate may also become an issue. The powerful estrogen suppressing action of this steroid and its 17aa stucture will cause it to negatively influence the cholesterol profile by lowering HDL and increasing LDL. It has also been reported to cause stiff joints, possibly related to its suppressive effect on estrogen levels.
Anecdotal reports of appetite suppression and general fatigue would lead one to believe that the liver stress from this 17aa compound is rather severe. For this reason it is recommended to use a liver protecting supplement prior to and during the use of this steroid.
Methylepitiostanol has a strong anabolic action that will lead to quick gains in lean muscle mass and strength with very little bloat. The gains will appear with minimal fat gain and increased vascularity.
Because methylepitiostanol can negatively affect joint comfort it is recommended to be stacked with an aromatizing or progestational compound. However, it is not recommended to stack this steroid with another 17aa oral.
Common Clones:
Epistane by Innovative Body Enhancement (IBE)
Havoc by Primaforce
Havoc by Recomp Performance Nutrition (RPN)
Epi-MAX by Anabolic Formulations
M14-E by Purus Labs
Methyl-E by Engineered Sports Technology (EST)
E-Max by Juggernaut Nutrition
E-Stane by Competitive Edge Labs (CEL)
Hemaguno by Spectra Force Research
Hemapolin by Starmark Labs
Epi-Mass by Armour Nutrition
References
“2{alpha},3{alpha}-Epithio-5{alpha}-androstan-17ß-yl 1-Methoxycyclopentyl Ether in the Treatment of Advanced Breast Cancer —A Preliminary Clinical Trial”
SOICHI KUMAOKA, M.D., OSAMU TAKATANI, M.D., MINORU YOSHIDA, M.D., SHIGETO MIURA, M.D., TETSUTO TAKAO, M.D., YÜJI HAMANAKA, M.D., MASARU IZUO, M.D. and TADAKAZU OKADA, M.D.
Japanese Journal of Clinical Oncology 4:65-68 (1974)
“Inhibited growth in vivo of a mouse pregnancy-dependent mammary tumor (TPDMT-4) by an antiestrogen, 2alpha, 3alpha-epithio-5alpha-androstan-17beta-ol (10275-S).”
Matsuzawa A, Yamamoto T.Cancer Res. 1976 May;36(5):1598-606.
“Antitumor Effect of Two Oral Steroids, Mepitiostane and Fluoxymesterone, on a Pregnancy-dependent Mouse Mammary Tumor (TPDMT-4)1”
Akio Matsuzawa and Tadashi Yamamoto
Cancer Research 37, 4408-4415, December 1, 1977
Epidrol by Genera Labs
Methyl Freak by Rockhard Formulations
Epistrong by Mrsupps
Chemical Name(s):
17a-methyl-1,4-androstadiene-3b,17b-diol
17a-methyl-androst-1,4-diene-3b,17b-diol
1,4-Methylandrostenedione
Chemical Formula:
C20H30O2
Molecular Weight:
302
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 40%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
NA
Legal Status (US):
Not listed as a controlled substance
Average Dose:
100-150mg/day standalone
50-100mg/day with stacking
Average Cycle Length:
4 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +3
Strength Gain: +3
Fat Gain (Negative Indicates Fat loss): +2
Water Retention: +3
Aggression: 0
Libido: +1
Acne: +2
Hair Loss: +2
Prostate Enlargement: +3
Liver Toxicity: +3
Lethargy +2
Characteristics
Methyl-1,4AD is a 17aa pro-steroid that converts to the illegal anabolic steroid methandrostenolone (Dianabol) at a rate of about 15-20%. It takes one conversion with 3b-HSD to convert methyl-1,4AD to Dianabol which probably happens fairly rapidly in the liver.
Since the average dose of Dianabol is generally 25-50mg/day with most steroid users, it is recommended to use this compound at 2-3x the dose for noticeable effects. While Methyl-1,4AD may have some activity on its own, it would be considered pretty weak until it makes the conversion to Dianabol.
Although this compound does not appear to have any progestational effects, it can convert to estrogen (methylestradiol) at a fairly decent rate. If users are very sensitive to estrogenic side-effects then an aromatase inhibitor may be taken along with this compound. However, if one is using an anti-estrogen with this steroid it begs the question, “why chose this steroid to begin with?” Most of the weight and size gains from this compound come from its estrogen conversion, therefore using an AI would noticeably limit the gains from this compound.
This compound has moderate androgenic effects, therefore users who are sensitive to hair loss should be careful with higher doses. The combined estrogenic and androgenic effects of this compound may lead to excessive prostate swelling, so frequent visits to the bathroom may become a problem. (although all steroids have this effect to degree)
Since this compound readily converts to estrogen it will likely have a lubercative effect on joints, contrary to many modern designer steroids that do not convert to estrogen and tend to cause joint pains. This would make this compound a good choice for bulking cycles where joint comfort is important for heavy weight lifting.
Because higher doses are needed with this compound, more stress is placed on the liver. As with any 17aa oral it is recommended to pre-condition the liver with a liver supporting supplement.
Users who use this at higher doses will experience similar gains to Dianabol including rapid increases in strength and size. Side-effects may include rapid weight gain, increase in blood pressure, bloating, back pumps and acne.
This compound could be used as a standalone for a bulking cycle, however users should be aware that much of the bloat and size gains from Methyl-1,4AD will be quickly lost after a cycle.
Common Clones:
M 1,4 ADD by Competitive Edge Labs (CEL)
M14-E by Purus Labs
M1, 4AD by Anabolic Formulation
References
Anabolic Pharmacology
Seth Roberts (2009)
Chemical Name(s):
5a-androstano[2,3-c]furazan-17b-tetrahydropyranol ether
Chemical Formula:
C24H36N2O3
Molecular Weight:
401
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 15%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
2-4 hours
Legal Status (US):
Not listed as a controlled substance
Average Dose:
200-300mg/day standalone
100-200mg/day when stacked
Average Cycle Length:
4-6 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +2
Strength Gain: +2
Fat Gain (Negative Indicates Fat loss): -1
Water Retention: 0
Aggression: 0
Libido: 0
Acne: +1
Hair Loss: +2
Prostate Enlargement: +1
Liver Toxicity: +1
Lethargy +1
Characteristics
Furazabol THP is the same compound as the illegal anabolic steroid furazabol except it is not 17aa methylated, and instead has a THP ether attached on the 17b position.
Furazabol does not aromatize and also has very minimal bloat. It has a moderately potent androgenic activity, giving it a fairly low risk for gyno or negative effects on the libido. However its androgenic effects may pose a problem for users prone to androgenic related hair loss.
Once the Furazabol THP reaches the stomach, most of the THP-ether is removed by the stomach acid to form the active Furazabol (the non-methylated version). Therefore, topical delivery of this compound is probably not worthwhile. Furazabol has a similar structure to the illegal anabolic steroid stanozolol (Winstrol). The only difference is the pyrazole ring has been replaced with a furazan ring. There is rumor that this compound has benefits for cholesterol levels. While some evidence proves that it can lower total cholesterol, it should be noted that the decrease in cholesterol is mostly due to a decrease in HDL. Therefore, your LDL/HDL ratio would become worse.
Overall this compound produces mild gains, but the side-effects are very mild too. Noticeable gains in lean muscle mass and strength are likely not going to be achieved unless doses of at least 200mg/day are used. Furazabol is going to produce very little water retention, therefore it should produce a lean and vascular appearance. Big increases in weight are not likely to happen with this steroid either, so increased blood pressure and painful back pumps should not be a problem.
The half-life of this compound is short, so dosages should be taken every few hours to keep blood levels stable. Although furazabol can successfully be used as a standalone it can be stacked with other compounds depending on the users goals.
Common Clones:
Furazadrol by Axis Labs
FURUZA-A by Competitive Edge Labs (CEL)
Orastan A by Competitive Edge Labs (CEL)
Winadrol by CTD Labs
Winabol by Generation X Labs
Chlomadrol-50 by German American Technologies (G.A.T.)
Furaguno by Spectra Force
References
“Enhancement of fibrinolytic and thrombolytic potential in the rat by treatment with an anabolic steroid, furazabol.”
Kumada T, Abiko Y.
Thromb Haemost. 1976 Nov 30;36(2):451-64.
Chemical Name(s):
2a,17a-dimethyl-5a-androst-3-one-17b-ol
2a,17a-dimethyl-etiocholan-3-one-17b-ol
Chemical Formula:
C21H34O2
Molecular Weight:
318
CAS:
NA
Q Qatio:
20
Anabolic #:
400
Androgenic #:
20
Oral Bioavailability:
Estimated at 50%
AR Binding Affinity:
NA
SHBG Binding Affinity:
High
Half Life:
~8 hours
Legal Status (US):
Not listed as a controlled substance
Average Dose:
10-30mg/day standalone
5-10mg/day when stacked
Average Cycle Length:
2-4 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +4
Strength Gain: +5
Fat Gain (Negative Indicates Fat loss): 0
Water Retention: +2
Aggression: +3
Libido: -1
Acne: +1
Hair Loss: +1
Prostate Enlargement: +2
Liver Toxicity: +5
Lethargy +2
Characteristics
Methyldrostanolone is a C-17 alpha alkylated steroid, originally developed by the American pharmaceutical company Syntex. This steroid is already active and does not require conversion. Methyldrostanolone is the 17aa version of the injectable steroid drostanolone (Masteron). This extra methylation makes this steroid about 3-4x more anabolic than Masteron, and slightly more anabolic than oxandrolone (Anavar). Due to the dimethylation, the toxicity of methyldrostanolone is greater than most other oral steroids. There have been many reported cases of heptatoxicity with this compound. (1-3)
Despite the fact that methyldrostanolone is a DHT derivative and cannot convert to estrogen, some users have still reported gyno like symptoms during or after a cycle. This effect is likely related to the strong SHBG binding effect and increase in freely circulating estrogen (and testosterone) from SHBG. Gyno symptoms may also be related to the fact that methldrostanolone lacks a strong DHT metabolite to antagonize the effects of estrogen (while also having a relatively low intrinsic androgenic value).
Having a fairly low androgenic value will mean that methyldrostanolone will be light on the hairline for most men. However those susceptible to male pattern baldness may still noticed accelerated hair loss during a cycle.
Because of the di-methylation, methlydrostanolone is considerably more resistant to breakdown, thus more potent per mg than most other steroids. However this makes it more liver toxic than other single methylated 17aa orals. Negative effects on the liver generally manifest as a condition known as reversible cholestasis. This is essentially a slowing or complete blockage of bile acids from the liver. Immediate signs of compromised liver function included reduced appetite and general sickness, which will soon be accompanied by yellowing of the eyes (jaundice), excessive itchiness and very dark urine. If these effects are noticed, methyldrostanolone should be discontinued immediately.
Because the effects on the liver it is very important to use a liver protecting supplement during any methyldrostanolone cycle. If not using a supplement to protect your liver, methyldrostanolone should never be used any longer than 2 weeks, with a maximum cycle length of 4 weeks with liver protection.
Other reversible side effects from methyldrostanolone may include increased blood pressure, reduced HDL cholesterol and lower back pumps.
Results wise, users should expect extreme strength increases and weight gain in a relatively short 2-4 week period. Weight gain upwards of 20lbs in 4 weeks is not unheard of with this incredibly potent compound. Although subcutaneous water gain would be minimal, intramuscular water retention should be expected. This is due to inhibition of 11b-hydroxylase and build-up of mineralcorticoids which encourage salt and water retention within the muscles. The most obvious physical effects will be improved vascularity, aggressive muscular pumps, and oily skin.
While methyldrostanolone can stack well with most other steroids, it should never be stacked with another methylated (17aa) steroid.
Common Clones:
Oxodrol 12 by IDS
Superdrol by Anabolic Xtreme
M-Drol by Competitive Edge Labs (CEL)
SD-1 by Performance Design
Methyl VOL by Engineered Sports Technology (EST)
Revenge SDX by Bioscience Technologies
S-Drol by Nutracoastal
E-Pol by Purus Labs
MethaDROL by IForce
Straight-DROL by Black China Labs
MethylDX3 by Physical Enhancing Industries
Oxevol (same as Dianevol) by Evolution Labs
Beastdrol by Mrsupps
References
Cholestatic Jaundice and IgA Nephropathy Induced by OTC Muscle Building Agent Superdrol.
Beata Jasiurkowski MD, et al.
The American Journal of Gastroenterology (2006) 101, 2659-2662;
Severe Cholestasis and Renal Failure Associated with the Use of the Designer Steroid Superdrol (Methasteron): A Case Report and Literature Review
John Nasr and Jawad Ahmad
Digestive Diseases and Sciences
Methasteron-Associated Cholestatic Liver Injury: Clinicopathologic Findings in 5 Cases”
Neeral L. et al.
Clinical Gastroenterology and Hepatology, Volume 6, Issue 2, February 2008, Pages 255-258
Identification of drostanolone and 17-methyldrostanolone metabolites produced by cryopreserved human hepatocytes”
Julie Gauthier, Danielle Goudreault, Donald Poirier and Christiane Ayotte
Steroids; Volume 74, Issue 3, March 2009, Pages 306-314
Chemical Name(s):
4-Hydroxyandrost-4-ene-3, 17-dione
4-hydroxy-4-androstene-3,17-dione
4-Hydroxyandrostenedione
Chemical Formula:
C19H26O3
Molecular Weight:
302
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 4%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
2-3 hours oral, Transdermal: Varies by matrix
Legal Status (US):
Not listed as a controlled substance
Average Dose:
Aromatase inhibition
100-200mg/day (transdermal)
150-250mg/day (oral)
Anabolic effects
800-1000mg/day (oral)
Average Cycle Length:
4-8 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +1
Strength Gain: 0
Fat Gain (Negative Indicates Fat loss): -1
Water Retention: +1
Aggression: 0
Libido: -1
Acne: 1
Hair Loss: 0
Prostate Enlargement: 0
Liver Toxicity: 0
Lethargy 0
Characteristics
Formestane is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme.
Formestane was originally used as an injectable for breast cancer patients, but due to its possible androgenic effects it has largely been replaced by non-steroidial AIs in the medical community. Most of its use is now is limited to the bodybuilding community since it is available as a legal dietary supplement for reducing estrogen and increasing testosterone production.
Although formestane can effectively reduce estrogen through oral consumption, its low oral bioavailability has lead to the development of several transdermal based products (which appear to offer higher efficacy at a lower dose).
Relative to 6-oxo and ATD, Formestane is a more potent aromatase inhibitor, which appears to effectively reduce natural estrogen levels by as much as 50% within several days (while higher doses may further suppress estrogen). Because of formestanes potent ability at reducing estrogen it will tend to reduce HDL levels, while increasing LDL levels, thus harming the cholesterol profile. For this reason, it is recommended to limit cycles of formestane to 8 weeks max.
Because formestane also has a strong affinity for the 5a-reductase enzyme it will reduce DHT levels in the body by effectively competing with testosterone for the 5a-reductase.
Formestane converts to the active androgen 4-hydroxytestosterone which has about half the anabolic potency, and about 25% of the androgenic potency as testosterone. This would suggest that fairly high doses of formestane (800-1000mg/day) could lead to some level of anabolic enhancement (although the amount required for this would surely lead to undesirably low estrogen levels).
Formestane is successfully used as a standalone during re-composition cycles to help reduce “bloat” and fat storage. It can also be used as an anti-estrogen to counter aromatization of aromatizing steroids.
Common Clones:
Formestane by Primordial Performance
Formex by Innovative Body Enhancement (IBE)
Formestane by Competitive Edge Labs (CEL)
Formadex by BCS LABS
References
Anabolic Pharmacology
Seth Roberts (2009)
Chemical Name(s):
4-chloro-17a-methyl-androst-1,4-diene-3b,17b-diol
Chemical Formula:
C20H29C1O2
Molecular Weight:
337
CAS:
NA
Q Qatio:
2.6
Anabolic #:
74
Androgenic #:
28
Oral Bioavailability:
Estimated at 40%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
~16 hours
Legal Status (US):
Not listed as a controlled substance
Average Dose:
100-150mg/day standalone
50-100mg/day when stacking
Average Cycle Length:
4-6 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +3
Strength Gain: +3
Fat Gain (Negative Indicates Fat loss): -1
Water Retention: +1
Aggression: +1
Libido: -1
Acne: 0
Hair Loss: +1
Prostate Enlargement: +1
Liver Toxicity: +3
Lethargy +0
Characteristics
Halodrol is a 17aa steroid that converts to the steroid oral Turinabol after interaction with 3b-HSD at an estimated rate of about 5%.
Because of this low conversion, doses must be higher than other 17aa pro-steroids. However, it is suspected that Halodrol has decent potency without conversion as good results are seen despite the relatively low conversion to Turinabol. Based on Vida’s data Halodrol appears to be about as potent as testosterone, and significantly less androgenic.
Because of the 4-chloro group, halodrol has no progestational effects, it cannot interact with the aromatase enzyme, and it produces inactive 4-chloro-DHT metabolites. This makes androgenic side-effects such as hair loss, high blood pressure, acne and prostate enlargement less likely. Anecdotal reports would also have us believe that side-effects with this compound are fairly mild.
Although caution would still need to be had, the low androgenic value of this compound would also make it one of the more appropriate anabolic steroids for women wishing increase lean mass yet avoid a deeper voice, increased hair growth, acne and clitoral growth. (Oral Turinabol was actually the preferred steroid for Olympic female athletes in East Germany)
The lack of androgenic potency might be expected to create problems with gyno, however the low SHBG binding affinity has minimal interference with SHBG levels and/or freely circuiting estrogen and testosterone. It does not appear that halodrol has a significant gyno risk.
Because halodrol must be used at such a high dose to see noticeable effects, liver toxicity may become an issue. Therefore it is recommended to use a liver protecting supplement before and during halodrol cycles.
Gains from Halodrol generally take a few weeks to notice, but users can expect solid increases in strength, lean muscle mass, improved vascularity and minimal water retention. This allows some of the gains to be kept after the cycle if good diet and training are continued. Quick dramatic gains in size and strength are not generally noticed with Halodrol.
It is used successfully as a standalone, but would be expected to stack well with most other steroids, except 17aa oral due to liver toxicity concerns.
Common Clones:
Halo-MASS by Anabolic Formulations
HD-1 by Performance Design
H-Drol by Competitive Edge Labs (CEL)
Halovar by Purus Labs
Hemadrol by Engineered Sports Technology (EST)
Halodrol-50 by Gaspari Nutrition
Oral Turinadrol by Juggernaut Nutrition
Super Halo by Black China Labs
H-Drol by Nutracoastal
Helladrol by Mrsupps
References
“Hepatotoxicity Associated With Dietary Supplements Containing Anabolic Steroids”
Michel I. Kafrouni, Robert A. Anders and Sumita Verma
Clinical Gastroenterology and Hepatology; Volume 5, Issue 7, July 2007, Pages 809-812
Chemical Name(s):
1-androsten-3b-ol-17-one
4-Dehydroepiandrosterone
Chemical Formula:
C19H28O2
Molecular Weight:
288
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 4%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
NA
Legal Status (US):
Not listed as a controlled substance
Average Dose:
500-1000mg/day standalone
200-500mg/day when stacked
Average Cycle Length:
4-6 weeks
Characteristics
4-DHEA is a naturally occurring non-methylated (non-17aa) pro-steroid.
4-DHEA, like DHEA, requires a 2 step conversion process involving 3b-HSD and 17b-HSD to convert it to Androstenedione/androstenediol, and then testosterone. What makes 4-DHEA slightly different from DHEA is a double bond in the 4th position rather than the 5th. This makes 4-DHEA less estrogenic by not acting directly upon the estrogen receptor like DHEA has been found to do.
Although 4-DHEA can aromatize to estrogen it is probably not enough to cause high estrogen related side-effects.
Overall results will be similar to or the original 4-AD banned back in 2004. Higher doses of this compound will produce fairly lean gains in muscle mass, with moderate improvements in strength. This product may produce some bloat from the estrogen conversion, which could be countered by administering an aromatase inhibitor, but this will largely defeat the purpose of using this compound to begin with.
Since this compound is naturally occurring and non-methylated overall side-effects will be fairly mild. However, high doses may also lead to oily skin, acne and increased blood pressure. Because this steroid is non-17aa there should be less concern about it negatively affecting the HDL/LDL ratio.
Because this compound can convert to testosterone it can also convert to DHT and other 5a-reduced metabolites. This can serve as a good stack with progestational or relatively non-androgenic compounds that may create problems with libido or gyno because of lacking androgenic potency.
Although this compound is relatively safe and moderately effective, its high cost has probably been the reason for its lack of popularity.
Common Clones:
4-AD UTT by Advanced Muscle Science (AMS)
References
Anabolic Pharmacology
Seth Roberts (2009)
Chemical Name(s):
17beta-hydroxy 2alpha,17alpha-dimethyl 5alpha-androstan 3-one azine
Chemical Formula:
C42H68N2O2
Molecular Weight:
632
CAS:
NA
Q Qatio:
2.2
Anabolic #:
210
Androgenic #:
95
Oral Bioavailability:
Estimated at 40%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
NA
Legal Status (US):
Not listed as a controlled substance
Average Dose:
20-40mg/day standalone
10-20mg/day when stacked
Average Cycle Length:
2-4 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +4
Strength Gain: +4
Fat Gain (Negative Indicates Fat loss): 0
Water Retention: +1
Aggression: +2
Libido: 0
Acne: +1
Hair Loss: +2
Prostate Enlargement: +2
Liver Toxicity: +5
Lethargy +1
Characteristics
Dimethazine is actually two steroid molecules bound together by a nitrogen atom. Upon ingestion, stomach acid separates the two steroid molecules that closely resemble methyldrostanolone (Superdrol).
Although dimethazine appears very similar to methyldrostanolone, the presence of a nitrogen at the 3rd position appears to increase its androgenic potency relative to its anabolic potency (210/95 compared to 400/20 for methyldrostanolone). Therefore, dimethazine could be considered a slightly weaker form of methyldrostanolone, but perhaps less likely to cause gyno related issues because of its higher relative androgenic value (and ability to antagonize estrogenic effects).
Otherwise, all side-effects and benefits could be considered relatively the same as methyldrostanolone. Liver toxicity and its associated side-effects of general sickness should still be expected, especially if the liver becomes compromised. Using a liver protecting supplement prior to and during a cycle of Dimethazine would be very important.
The quick gains in size and strength will likely be accompanied by increases in intense back pumps, high blood pressure, shortness of breath and oily skin. Vascularity would also be expected to improve with this compound due to the increase in extra-cellar water and possible decrease in subcutaneous water weight.
Because this compound is a 17aa oral, it is not recommended to be stacked with other 17aa oral steroids.
Common Clones:
Dymethazine by IForce
References
“Oral administration of an anabolic-androgenic steroid dimethazine increases the growth and food conversion efficiency and brings changes in molecular growth responses of carp (Cyprinus carpio) tissues”
LONE K. P. (1) ; MATTY A. J. ;
Nutrition reports international
“Contribution to the study of the proteoanabolic effects of dimethazine. (Clinical research)”
CEI C, ANSELMI G.
Gazz Med Ital. 1963 Feb;122:57-61
“A new steroid having proteo-anabolic action: dimethazine.”
DE RUGGIERI P, MATSCHER R, GANDOLFI C, CHIARAMONTI D, LUPO C, PIETRA E, CAVALLI R.Arch Sci Biol (Bologna). 1963 Jan-Mar;47:1-19.
Chemical Name(s):
17a-methyl-etioallocholan-2-ene-17b-ol
17a-methyl-5a-androst-2-ene-17b-ol
Chemical Formula:
C20H32O
Molecular Weight:
288
CAS:
NA
Q Qatio:
6.5
Anabolic #:
1200
Androgenic #:
187
Oral Bioavailability:
Estimated at 40%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
~9 hours
Legal Status (US):
Listed as a controlled substance
Average Dose:
40-60mg/day standalone
10-30mg/day when stacked
Average Cycle Length:
4 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +4
Strength Gain: +3
Fat Gain (Negative Indicates Fat loss): +1
Water Retention: +2
Aggression: +2
Libido: 0
Acne: +1
Hair Loss: +1
Prostate Enlargement: +1
Liver Toxicity: +3
Lethargy +2
Characteristics
Desoxymethyltestosterone (DMT) is a 17aa steroid with equal toxicity as other 17aa oral steroids. While nearly all anabolic steroid molecules have a 3-keto group, Desoxymethyltestosterone lacks it, and has a 2-ene structure. This compound is readily active and does not require conversion.
DMT does not aromatize, nor does it appear to have any progestational activity, yet some users still experience gyno symptoms and bloat from this compound. This is likely related to the lack of androgenic potency from this compound (to antagonize the effect of estrogen). DMT may also contribute to gyno by displacing estrogen (and testosterone) from SHBG. It has also been proposed that DMT can inhibit 11b-hydroxylase and thus increase intracellular sodium and water retention by building up mineralcorticoid levels.
Depending on where you look, DMT has been reported to be 2-12 times more anabolic and 0.4-2 times as androgenic as methyltestosterone. It has been proposed that DMT is a naturally occurring substance because it has an almost identical structure to delta 2-androstenol, a naturally occurring pheromone in mammals. However, being a 17aa steroid hormone makes it synthetically altered and not naturally occurring. Either way, it is now a controlled substance in the United States.
Users should expect significant strength increases, weight gain, and bloat. Weight gains upwards of 20lbs in 4-6 weeks are not unheard of with this compound. The most obvious physical side effects will be strong muscular pumps, shortness of breath, high blood pressure, oily skin, and bloating. If users wanted to minimize toxic effect on the liver or other side effects, DMT could be used at doses as low as 10mg/day for a decent effect.
Being that this compound is methylated, it should not be stacked with other methylated compounds. Having moderately low androgenic activity, DMT may negatively affect the libido and erectile function. This side effect could be offset by stacking DMT with testosterone or one of its non-aromatizing metabolites to preserve DHT levels.
Common Clones:
P-Plex by Competitive Edge Labs (CEL)
Phera-Plex by Anabolic Xtreme
Nasty Mass by Purus Labs
Phera-VOL by Engineered Sports Technology (EST)
PheraFLEX by IForce
D-Stianozol by Nutracoastal
Pheradrol by PH Design
P-Max by Growth Labs
Phera-MAX by Generic Labs
Phera-BOL by Juggernaut Nutrition
Phera-Mass by Kilo Sports
Straight Phlexed by Black China Labs
References
“Characterisation of the pharmacological profile of desoxymethyltestosterone (Madol), a steroid misused for doping”
P. Diel, A. Friedel, H. Geyer, M. Kamber, U. Laudenbach-Leschowsky, W. Schänzer, M.
Thevis, G. Vollmer and O. Zierau
Toxicology Letters; Volume 169, Issue 1, 28 February 2007, Pages 64-71
Chemical Name(s):
5-estren-3b-ol-17-one
Nordehydroepiandrosterone
Chemical Formula:
C18H26O2
Molecular Weight:
274
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 4%
AR Binding Affinity:
NA
SHBG Binding Affinity:
NA
Half Life:
NA
Legal Status (US):
Not listed as a controlled substance
Average Dose:
300-600mg/day standalone
200-300mg/day when stacked
Average Cycle Length:
4-6 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +2
Strength Gain: +1
Fat Gain (Negative Indicates Fat loss): 0
Water Retention: +1
Aggression: +1
Libido: -2
Acne: +1
Hair Loss: 0
Prostate Enlargement: 0
Liver Toxicity: 0
Lethargy +1
Characteristics
norDHEA is a non-methylated (non-17aa) pro-steroid. (naturally occurring in trace amounts in humans)
norDHEA can convert to the illegal anabolic steroid nandrolone by converting to norandrostenediol/norandrostenedione, and then to nandrolone. Nandrolone is known to have stronger anabolic effects than testosterone, yet weaker androgenic effects.
norDHEA will aromatize to estrogen less than regular DHEA, but because it is a nor compound it lacks strong androgenic metabolites. For instance, after nandrolone interacts with 5a-reductase, the metabolite dihydronandrolone (DHN) is formed, which is a weaker nor-version of DHT.
Ironically, the lack of estrogen conversion from norDHEA is probably balanced by the lack of androgenic potency and progestational effects, which makes the possibility of bloating and experiencing gyno about as likely as with regular DHEA.
One difference between norDHEA and DHEA that should be considered is the fact that norDHEA will have less androgenic effects, which may pose less risk of androgenic related hair loss and/or acne. This may be a smart choice for some men, and a decent choice for women looking for a moderately anabolic compound without much androgenic effect. (to avoid masculinizing side-effects)
Because of the low bio-availability, high doses must be used to notice gains in lean muscle mass and strength. Even with higher doses, the gains will be mild to moderate. Some bloat should be expected from the estrogenic and progestational effects of the nor-steroids. Because this steroid is non-17aa there should be less concern about it negatively affecting the HDL/LDL ratio.
Like the other DHEA derivatives, norDHEA would be useful in a transdermal application since the enzymes needed for the conversions to more powerful metabolites are concentrated in the skin and absorption through the skin using a good transdermal delivery cream could allow for 5-10x higher absorption than oral.
This compound would stack well with almost any other steroid, except those with progestational activity.
Common Clones:
Decavol by Advanced Muscle Science (AMS)
References
Anabolic Pharmacology
Seth Roberts (2009)
Chemical Name(s):
17a-methyl etioallocholan 17b-ol 3-hydroxyimine
Chemical Formula:
C20H33NO2
Molecular Weight:
319.5
CAS:
NA
Q Qatio:
2.4
Anabolic #:
380/24
Androgenic #:
158/20
Oral Bioavailability:
Estimated at 40%
AR Binding Affinity:
NA
SHBG Binding Affinity:
High
Half Life:
NA
Legal Status (US):
Not listed as a controlled substance
Average Dose:
75-100mg/day standalone
50-75mg/day when stacking
Average Cycle Length:
4-6 weeks
Characteristics
Promestanolone is a 17aa pro-steroid which converts to the illegal anabolic steroid methyl-DHT (mestanolone).
There is no human clinical data on promestanolone, but it is most likely exerting its effects by converting to methyl-DHT. The acidic environment in the stomach would be responsible for converting the 3-hydroxyimine group to a 3-one — thus rapidly changing it to methyl DHT. Therefore results and side-effects would be considered to be very similar to methyl-DHT.
Although DHT can be deactivated in skeletal muscle tissue by 3b-HSD it is likely that this enzyme pathway can be overwhelmed if this compound is taken at a high enough dose. Methyl-DHT has some activity on the progestin receptor, but not to a high degree. It has moderate anabolic but high androgenic effects. It binds strongly to SHBG, therefore free testosterone and estrogen can be expected to rise by displacement from SHBG.
Since this is a 17aa compound, liver toxicity will be an issue with high doses or long term use. For this reason users should consider priming the liver with a liver supporting supplement before and during a Promestanolone cycle. Users will also experience minimal subcutaneous water retention since there is no conversion to estrogen. However, intracellular water and sodium retention will increase by inhibition of 11-beta hydroxylase and mineralocorticoid build up.
Users may also experience an increase in aggression and mood swings which is a common side effect of many steroids with high androgenic value. This makes this compound an excellent pre-lifting or pre-competition steroid.
Promestanolone should produce solid lean gains in muscle as a standalone. However for those looking to add additional bulk to their cycle, promestanolone would stack with with virtually any other non-17aa oral.
Common Clones:
D-Plex by Competetive Edge Labs (CEL)
The ONE by Applied Nutraceuticals
References
“Effect of 1-alkyl substitution on the biological action in a series of androstanes.”
Cekan Z, Pelc B.
Steroids. 1966 Aug;8(2):209-18.
“Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin.”
Saartok T, Dahlberg E, Gustafsson JA.
Endocrinology. 1984 Jun;114(6):2100-6.
Chemical Name(s):
19-norandrosta-4,9-diene-3b,17b-dione
estra-4,9-diene-3b,17b-dione
4,9 Estra
Chemical Formula:
C18H22O2
Molecular Weight:
270
CAS:
NA
Q Qatio:
NA
Anabolic #:
NA
Androgenic #:
NA
Oral Bioavailability:
Estimated at 20%
AR Binding Affinity:
5
SHBG Binding Affinity: [/B
]NA
[B]Half Life:
NA
Legal Status (US):
Listed as a controlled substance
Average Dose:
100-200mg/day standalone
50-100mg/day when stacking
Average Cycle Length:
4-6 weeks
Ratings (On Scale of -5 to +5):
Muscle Gain: +3
Strength Gain: +3
Fat Gain (Negative Indicates Fat loss): -1
Water Retention: +2
Aggression: +3
Libido: -2
Acne: 0
Hair Loss: +1
Prostate Enlargement: +2
Liver Toxicity: +1
Lethargy 0
Characteristics
Dienedione is a non-methylated steroid that converts to a steroid known as 17b-hydroxy-estra-4,9,(10)-dien-3-one (dienolone).
Although dienedione may have some anabolic activity on its own, it gets most of its effects from conversion to dienedrone by interaction with 17b-HSD. This steroids overall effects are somewhere between trenbolone and nandrolone.
Dienedione is known for causing night sweats via its powerful thermogenic effects similar to trenbolone. This thermogenic effect makes dienedione an excellent choice for dropping bodyfat during cutting cycles.
As a 19-nor this compound has decent progestational effects which may lead to gyno symptoms, libido loss and aggressive mood swings. Part of the reason gyno may be a problem with this compound is also because it lacks androgenic potency and down-regulates DHT levels during cycle, which is the body’s natural estrogen blocker.
Dienedione does not convert to estrogen, although it can still lead to the side-effects mentioned above. Because this compound is not 17aa liver toxicity is not really a concern. However some users have reported elevated liver enzyme values during cycle, although this could be related to other factors.
Users usually experience rapid gains in strength and aggression, followed by significant weight gain after several weeks. The results are generally fairly lean with only minor bloat due to the progestational effects.
Dienedione can be used as a standalone. In an effort to prevent libido loss and gyno, it may be stacked with testosterone or one of its non-aromatizing metabolites to help keep DHT levels elevated during cycle.
Common Clones:
Dienedrone by Advanced Muscle Science (AMS)
Liquidrone UTT by Advanced Muscle Science (AMS)
X-Tren by Competitive Edge Labs (CEL)
Tren Xtreme by American Cellular Labs
Tren 250 by Genetic Edge Technologies (GET)
Trena by Nutracoastal
References
Anabolic Pharmacology
Seth Roberts (2009)
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