myostatin inhibitor... anyone interested in these?

[BBG]

How interested is everyone here in researching with a legit myostatin inhibitor? No details yet j/w.

[Rodja]

Not at all. There's a certain level of genetics that I will not cross and this is one of them.

[burlyman30]

Interested in follistatin with virus attached. Pretty sure that's impossible to get.

Sent from my DROID RAZR using Tapatalk 2

[BBG]

Interested in follistatin with virus attached. Pretty sure that's impossible to get.

Sent from my DROID RAZR using Tapatalk 2

I'm pretty sure it is too. It's not follistatin that I was thinking about. Just wanted to see how interested folks are here in research with it.

And I totally understand the point you make Rodja. Probably the safest way to view it.

[xxiv]

x2.


Not at all. There's a certain level of genetics that I will not cross and this is one of them.

[h2s]

One that has some concrete evidence behind it, coming from user experience and not hype? Yes. What is currently available? No.

[BBG]

One that has some concrete evidence behind it, coming from user experience and not hype? Yes. What is currently available? No.

Yeah there are studies backing it up. None in humans (that I know of yet). I'll get back to you guys, it seems quite interesting. Might need to do some research with it.

[Rulk]

I'd have to see some decent feedback before thinking of biting.

[Jelisej]

From wikipedia: "Myostatin levels are effectively decreased by creatine supplementation."

To be honest, I'm not in AAS really, but myostatin inhibitor, I would found very hard to resist that temptation. Stuff seems impresive. It can really turn you into Hulk.
World's Strongest Boy Sets Air Push-up Record - Asylum.com (http://www.asylum.com/2010/02/24/worlds-strongest-boy-sets-air-push-up-record/)


Myostatin-Related Muscle Hypertrophy - GeneReviewsâ„¢ - NCBI Bookshelf (http://www.ncbi.nlm.nih.gov/books/NBK1498/)

[naeydrin]

Tempting:)

[BR99TAL]

looked a bit about that long ago.
from what I remember, theoretical would it be phenomenal, but there is way too much involved and just deactivating(am i right on this?) of mystation would only produce a reaction where your body counters this with other mechanisms. hence, there are hardly results.

[Jimbuick]

Seems interesting.

[USN HM 350Z]

my guinea pig would be interested in this....

[BBG]

I'll let you guys know what's up in a week or two ;)

[Rulk]

I'll let you guys know what's up in a week or two ;)

Are we gonna have to change your name to R(Real)BBG soon?

[Scope75]

I've never researched with anything before but a myostatin inhibitor has always interested me.
With virus and proven to work, I'd pay a good money for that!!

[Anonymous]

Myostatin and GH/IGF-1 are the only ways to inducehyperplasia. The peptide route takes 8+ months for gains far as I am aware, and 8+ months of 20x increase in GH is asking for cancer down the road. I used to think of it as a decant option but after learning a little more I'm not for that anymore.

Myostatin on the other hand isn't splitting every cell in the body. It just differentiates stem cells to your muscles mostly and has scarce evidence regarding bones. Cartilage and tendons would be the issue with myostatin though. However unless you can knockout both myostatin genes I would not worry about joint problems. Unless you can inhibit it up to 40% or more you won't be doing much.

Creatine and resistance training combined can inhibit 1/6th of myostatin expression (Creatine little impact on that 1/6th that was mostly a result of resistance training), after that there are very few other supplements you can add into the mix.


For anybody wanting to research, another name for Myostatin is GDF-8 (Growth Differentiation Factor 8), part of the TGF-b family. Which reminds me, only effective ways to inhibit it is by inhibiting TGF-b which leads to knocking out a bunch of other growth factor, so don't go that route.

[burlyman30]

^^^ Good info from a guy with no name.

[Right Hook]

Decorin would effectively inhibit myostatin. Good luck getting it in stable form for a decent price.

[BBG]

Nice info Anon, thanks for the post.

[Jelisej]

Nice info Anon, thanks for the post.

How many weeks left?
Your tactic of keeping us in dark is working in my case, I'm more curious and there is more tension than when I was waiting for second season of "Prison break".

[BBG]

How many weeks left?
Your tactic of keeping us in dark is working in my case, I'm more curious and there is more tension than when I was waiting for second season of "Prison break".

It may need to be put off another week or so! You know, in classic primordial fashion haha

[Scope75]

Lol!!
Looks like it'll be out around May or June then, but your missing the pre sale to be in true PP fashion.

[Sorrow]

Hm, yeah true primordial flash back here. Although in all fairness good things did come to those who waited.

[BBG]

True, but it looks like waiting will be awhile :)

[Jelisej]

True, but it looks like waiting will be awhile :)

Any details yet? Who, how, why, how many, how much...anything?
BBG, you should be a screenwriter for Spielberg, in your thrillers people would be kept guessing till the very end of the film.

[Sorrow]

so at the two week mark, even a hint at what might be up the proverbial sleeve?

[Scope75]

I'm still interested too!!

[BBG]

Damn it guys :) it'll be awhile longer, I'll update when I have word.

[Scope75]

You know us supp junkies...
Always looking for the next best thing.
Now get a move on it. Lol

[Anonymous]

Hows the statin of myo going?

[ctAL]

some product called follidrone is coming out from black lion research

[Jelisej]

some product called follidrone is coming out from black lion research

Seems like load of bull***...
According to their theory, person will make more progress in strength in 7 days than average weightlifter in 7 years.
"In addition our internal testers reported serious strength gains including-
-100lb increase in Deadlift in 4 days
-20lbs per arm on DB incline press in 10 days."

[Rodja]

Seems like load of bull***...
According to their theory, person will make more progress in strength in 7 days than average weightlifter in 7 years.
"In addition our internal testers reported serious strength gains including-
-100lb increase in Deadlift in 4 days
-20lbs per arm on DB incline press in 10 days."

Anything that claims those kind of results is BS.

[Jelisej]

Anything that claims those kind of results is BS.

Definitely. If real myostatin inhibitor was developed, I beleive it would take more than 4 days to start working and to see progress. All companies that were working on myostatin inhibitor failed- some made little progress but nothing concrete and gave up, couple of pharmacies announced big progress and then suddenly stopped...
Interesting articles:
Research on myostatin inhibitor ACE-031 stopped – but the stuff does work (http://www.ergo-log.com/research-on-myostatin-inhibitor-ace-031-stopped.html)

ACE-031 Study Terminated: What Does This Mean? - PPMD Community (http://community.parentprojectmd.org/profiles/blogs/ace031-study-terminated-what)

Myostatin blockers destroy tendons (http://www.ergo-log.com/myostatintendons.html)



BTW, one of side-effect of ACE-031 they did not list is supressed FSH- tough must be noted that research was done on women, and also no further investigation was done so we can only guess.

[O.N.]

I've used GDF8 (myostatin propeptide) so have a few friends with great success. This was a few years ago when you could trick legit research suppliers into selling it to you.

Gains were almost instantaneous you would gain 2kg (4.4lbs) in the first week, mostly due to increase protein and glycogen retention.
I also made use of it at the end of a cycle, i was running 750mg per week for 10 weeks then for an additional 4 weeks i ran 250mg per week with the GDF8 and IGF1, before this 4 week period i had a dexa scan to see where my body was at and by the end of 4 weeks i had gained 5.2kg (11.4lbs) in lean muscle tissue confirmed by dexa scan, my body weight was already 105kg (231lbs) with the final weigh in around 112kg (246lbs) from memory. So I already had a fair amount of muscle mass and as you know to gain 5.2kg of lean muscle tissue even over 10 weeks is a decent gain for my weight but to gain it in 30 days was unreal....not to mention i reduced my dose from 750mg to 250mg.

Initially when i first took it i thought i might turn into the hulk within a week but that wasn't the case, the gains stayed that's for sure, also I made use of it several times when not on any cycles and had comments from friends like "are you back on the juice again" which i was very happy to say i wasn't.

I was taking it IM at 25mcg per shot usually you can notice a hunger increase from it fairly quickly and you eat the house out, the most optimal use seems to be 1 shot every 7-10 days judging by the level of hunger which would stay steady and drop off around the 14 day mark. At one stage i pushed it up to 25mcg every 3rd day however this didn't make all that much of a difference weight wise. I also pushed the dose up to 100mcg again there was no difference. The hunger increase was the best way to feel when it was working and when it wasn't as the increase was very substantial as was the sleep times of 12-14hrs....obviously the body wanted to grow and grow.

The injections hurt like hell for about a minute, worse than IGF mixed with acetic acid....much worse.

SubQ injections had no effect the peptide didn't work, i wasn't game to do it IV however i think this would work best if you tried.

I had 4-5 friends also use it all experience the same effects as i have described. This was as said the legit stuff costing about $80USD per 25mcg.

It was also stated in the product description that 70% of myostatin would bind to its propeptide (GDF8) in vitro which was relevant in vivo. Which leads me to believe that the 25mcg dose every 7-10days was plenty as you cannot bind GDF8 to myostatin that is already bound.....so basically more is not better.

If you are taking GDF8 and you take 25mcg once per week and you do not gain at least 1-2kg (2.2-4.4lbs) then what you have is fake as all 5 or so people i know that have taken it have all had these first week gains.

I also think the way in which it works is going to have very decent long term benefits being that protein and glycogen retention is higher, overtime muscle tissue will stretch because of this and grow and also additional nutrient supply is available when needed. This is not DNA altering it is only binding and inhibiting up to 70% of your circulating myostatin.

[nate3993]

Dam. That sounds like an one impressive ass mother fukin drug. I want me some of that!

[Grape Ape]

How did you trick them again?

[O.N.]

How did you trick them again?

I'd rather not implicate myself as my name is tied to most things on the forum, but you can figure it out easily enough.

[ctAL]

Dam. That sounds like an one impressive ass mother fukin drug. I want me some of that!


fuk yea it does..............

im super intrigued.........

ive never injected anything yet but what i just read sounds fantastic

sides/ pct?

edit:

damn............ive learned so much since bein a member on this forum. this is some interesting/stuff........its crazy how people are so willing to experiment on themselves when anything new comes out without too much info, scary as hell to me. just read a couple discussions from 2006-2010 on other forums

at the moment i want acvr2b over a gear cycle, not any black market stuff, legit bio engineer company lol

i need to be VERY financially well off when i hit 30+, when more research and other things start to come in.

Milo Biotechnology Announces FDA Orphan Drug Designation for AAV1-FS344 for Treatment of Duchenne... -- CLEVELAND, Dec. 12, 2012 /PRNewswire/ -- (http://www.prnewswire.com/news-releases/milo-biotechnology-announces-fda-orphan-drug-designation-for-aav1-fs344-for-treatment-of-duchenne-and-becker-muscular-dystrophy-183166441.html)

this looks very interesting........

[longBallLima]

for the older folks who wanna try it out lol

Study to Assess the Safety and Bioeffect of REGN1033 (SAR391786) - Full Text View - ClinicalTrials.gov (http://clinicaltrials.gov/ct2/show/NCT01910220?term=REGN1033&rank=3)

[powerlift66]

Anything that claims those kind of results is BS.

The people on AM forum are buying up all the BL Follidrone, claiming its the greatest thing since real juice... Odd...

[guardianactual]

Myostatin inhibition increases muscle*mass (http://www.musclechemistry.com/upload/articles-new-/72538-myostatin-inhibition-increases-muscle-mass.html?highlight=myostatin)

ACE 031 myostatin clinicals (http://www.musclechemistry.com/upload/articles-new-/71618-ace-031-myostatin-clinicals.html?highlight=myostatin)

If I'm unable to post links to forums I'm sry.. I'm apart of SOOOOOOOOO many forums IDK the rules anymore LMAO if it's a problem plz inform me. Otherwise enjoy :)

[KGPL]

I'm interested in the follidrone. Any side effects?

[Rodja]

The people on AM forum are buying up all the BL Follidrone, claiming its the greatest thing since real juice... Odd...

I've seen all the reviews and praise of it without two very important things: before/afters and anything approaching the strength increases that were claimed. The primary people that are all over it tend to be newish to lifting and it's hard to take any dude that weighs 160lbs seriously when it comes to supplements.

That being said, I've been using MyoSynergy by EvoMuse for over a month (Matt and I go back the better part of a decade) and it has been impressive. However, the (-)-Epi is only one part of the blend.

[O.N.]

Anyone taking anything that is suppose to reduce myostatin these effects here should be felt: http://www.swolesource.com/forum/human-growth-hormone-peptides/352-myostatin-inhibitor-anyone-interested-these-4.html#post35310 (http://www.swolesource.com/forum/human-growth-hormone-peptides/352-myostatin-inhibitor-anyone-interested-these-4.html#post35310)

[guardianactual]

LMAO 5'11 160 I bet! I mean @ my height 5'5 160 isn't bad Franco was 185 5% I see a lot of logs on shit like this freaking by dudes 5'10-5'11 160-170 lbs and 15% I just can't take em seriously either.

follidrone to mean if ur speaking of (-)-Epicatechin, Rice Flour I highly doubt it works but IDK.

MC IGF1 LR3 is awesome tho & HGH is as well. Ostarine's decent... I'm not 100% on the myo inhibitors too inconclusive & u need a reliable source... It's not cheap either! But if any of y'all use it SHARE!

- - - Updated - - -

LMAO 5'11 160 I bet! I mean @ my height 5'5 160 isn't bad Franco was 185 5% I see a lot of logs on shit like this freaking by dudes 5'10-5'11 160-170 lbs and 15% I just can't take em seriously either.

follidrone to mean if ur speaking of (-)-Epicatechin, Rice Flour I highly doubt it works but IDK.

MC IGF1 LR3 is awesome tho & HGH is as well. Ostarine's decent... I'm not 100% on the myo inhibitors too inconclusive & u need a reliable source... It's not cheap either! But if any of y'all use it SHARE!

[O.N.]

Any update on guys running logs for the (-)-Epicatechin on other boards?
Have read a little science and it is intriguing to be honest.

Has anyone had any gains like i have described with my myostatin propeptide use, an immediate gain within the first week 1-2kg (2.2-4.4lbs) from an increase in protein and glycogen retention?
Or massive increases in appetite?