Resveratrol for prevention in human prostate cancer

The following represents an article originally published for Primordial Performance.

©Eric Potratz, All Rights Reserved.
Printed with Permission.

October 14th, 2009 – With over a decade of test tube and animal research behind resveratrolís anti-cancer benefits, it finally appears that researchers are ready to take the fast track to human clinical trials in cancer prevention and therapy. (1)

Resveratrol is abundantly found in nature in various fruits, nuts and other plants and accounts for 5 to 10% of the biomass in grape skin. (2) Over the years, resveratrol has demonstrated multiple inhibitory actions on the three stages of cancer including initiation, promotion and progression. (1-3) Part of resveratrols action in preventing initiation of cancer is from its potent anti-oxidant effect and ability to scavenge free radicals. Promotion of tumor growth appears to be inhibited by Resveratrol’s ability to exert anti-inflammatory activity through inhibition of cyclooxygenases (COX-1 and COX-2).

Resveratrol also inhibits cancer cell growth by antagonizing the action of androgens at the androgen receptor (AR) in prostate cancer cells. Whether this anti-androgenic effect of resveratrol has effects on AR in muscle, fat or mammary tissue remains to be seen.

-Eric Potratz
Founder & President




References

1. CancerPrevention and Treatment withResveratrol: From Rodent Studies to Clinical Trials
Anupam Bishayee
CancerPrevention Research,May 2009; 2: 409 – 418

2. Resveratrol: A Candidate Nutritional Substance for Prostate
Cancer Prevention
Jubilee R et al.
J Nutr.2003 Jul;133(7 Suppl):2440S-2443S

3. Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells.
Mitchell, S. H. et al.
Cancer Res. 59: 5892-5895. (1999)