Question about M-sten and potential androgen receptor deactivation?

Looking up methylstenbolone pulls few results in google scholar as I try to find studies so I am just left with what blogs and companies claim.

M-sten is toxic due to the fact that it takes long to be metabolized, as I am reading here "due to its ability to resist metabolization" and here "because it is a di-methyl androgen resistant of typical metabolic deactivating pathways". This has to do with the liver but would this apply to androgen receptor clogging? A side effect of long cycles is that all the androgen receptors are filled with old androgens that already did their function and just sit in the receptor site.

This is just making me worried that M-sten might not be the best for maintaining gains post cycle, and longer depending on how long it takes to clear up the androgen receptors for natural test to fill in, I could be wrong and this only applies to the liver.


So how does this work?

Quote:

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Originally Posted by Anonymous

A side effect of long cycles is that all the androgen receptors are filled with old androgens that already did their function and just sit in the receptor site.

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Do we know this for a fact though? Or at least is it supported by some evidence in studies?

Quote:

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Originally Posted by BBG

Do we know this for a fact though? Or at least is it supported by some evidence in studies?

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I should have mentioned, this was also something I didn't find in a study. However we already do know that Epistane acts as an estrogen antagonist by being a competitive inhibitor to estrogen, so the idea is not so far fetched but a long term cumulative effect is what I am worried about. I tried all sorts of searches on androgen receptor density and sensitivity in general and found this "article", I than googled a quote from the article and found it again on some other forums. So this post link has that article I firs read followed by another one, the second being more scientific.

Link: Check the quotes in this post
Receptor burnout and down regulation, no. Receptor desensitivity, maybe?


Back on the old PP forum someone posted studies about androgen receptor sensitivity but that forum is gone sadly, so I can't backtrace what that guy found way back. I am not too worried about this with natural hormones like Test and DHT PH's since the body is built to handle those hormones, but I have always been weary about designer steroids.