I can't say for sure. I've taken both, but I took the stronger extract when I was well recovered. If you're having second thoughts, even for peace of mind, just stick to the 1:1. It works and I've never had any issues with it.
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I took the 8:1 extract during the last coupel weeks of my androsterone cycle. I now have worse brain fog and mental sides than before, and I am not sure if this is maybe in part due to the lion's mane. I remember after taking it a few days I started to get really weird and concerning mental effects, but I was already getting bad mental effects on andro. Lion's mane upregulates NGF which could icnrease dht, but if it's a 5-ar inhibitor it could drop allopregnenlone. Right now I feel as if I have more DHT but lower allopreg than before my cycle.