That’s the first I’ve heard that, I’d imagine a GABA antagonist wouldn’t help anyone in general that’s deficient in GABA
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That's true anyway, but I'm almost certain glycine doesn't interact with the GABA receptor (since it's already an agonist for the glycine receptor), and the mechanism of action is the enhancement of 5-ar which increase allopregnanolone (that's what affects the GABA receptors).
I've started taking 5mg of glicine plus magnesium two nights ago for sleep issue.
Have to say that there are some positive effects.
Is it dangerous taking glicine any night? Would my body build tolerance? I can't find Albizia or blue vervain here.
@Cdsnuts
But is it dangerous to inhibit these neurotransmitters? And which neurotransmitters are we talking about?
It's not a question of inhibiting them. It isn't like 5 alpha reductase inhibitors where you prevent something from happening. Rather inhibitory neurotransmitters, when they reach the receptor, in this case the glycine receptor, cause the brain to slow down. A big issue in what most people have is that the lack of allopreganolone means that the brain has issues slowing down, therefore meaning you will struggle to unwind, have insomnia, brain fog etc.
Going back to the first question, it isn't dangerous to take glycine.
Oh shit! You did the test too. It's crazy right? Several others tested as well and we all have the same patterns. Even the hormones. Mine were testing low-normal at serum but extremely high at urine. That's indicative of metabolizing hormones too quickly. You're literally just pissing them out before they can actually be utilized.
Glycine agonizes the NMDA receptor. It also agonizes the glycine receptor, which is closely related to the GABAA receptor. Can't find anything that it directly plays on the GABAA receptor but it will indirectly increase agonism of it by stimulating production of Allopregnanolone.