Methandrostenolone (Dianabol)

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11-16-2012
burlyman30

Methandrostenolone (Dianabol)

Anabolic steroids impair the exercise-induced growth of the cardiac capillary bed.

Quote:

Tagarakis CV, Bloch W, Hartmann G, Hollmann W, Addicks K.

Source
Institute I of Anatomy, University of Cologne, Germany.

Abstract

BACKGROUND:
Concomitant application of anabolic-androgenic steroids and physical exercise can induce cardiac hypertrophy. These experiments investigate the still unknown response of the cardiac myocytes and capillaries to the combined influence of various anabolic steroids and muscular exercise.

METHODS:
Female SPF-NMRI mice were divided into the following groups: a) sedentary control, b) exercise (treadmill running); c) sedentary receiving Dianabol; d) exercise + Dianabol; e) exercise + Oral-Turinabol. After 3 and 6 weeks the left ventricular papillary muscles were studied morphometrically. Evaluated variables: minimal myocyte diameter, number of capillaries around a single myocyte, capillary density and intercapillary distance.

RESULTS:
Only the anabolic steroids + exercise groups showed a mild myocyte hypertrophy. In contrast, only exercise alone caused a significant increase of the capillary density after both experimental periods; e.g. capillary density after 6 weeks (capillaries/mm2, mean values +/- standard deviation, p < 0.05): control (4,272 +/- 287), exercise (5411 +/- 755), dianabol (4,004 +/- 333), dianabol + exercise (4,076 +/- 403), oral-turinabol + exercise (4,053 +/- 306). Moreover, unlike all other regimens, only exercise alone shortened the intercapillary distance. Finally, exercise without drugs induced the greatest increase in the number of capillaries around a single myocyte.

CONCLUSIONS:
Anabolic steroids combined with exercise: 1) induce mild hypertrophy of the cardiac myocytes, 2) impair the cardiac microvascular adaptation to physical conditioning. The microvascular impairment may cause a detrimental alteration of the myocardial oxygen supply, especially during muscular exercise.

Anabolic steroids impair the exercise-induc... [Int J Sports Med. 2000] - PubMed - NCBI
11-16-2012
burlyman30

Insulin action and dynamics modelled in patients taking the anabolic steroid methandienone (Dianabol).

Quote:

Godsland IF, Shennan NM, Wynn V.

Abstract

Plasma glucose and insulin concentrations were measured during oral (OGTT) and intravenous (IVGTT) glucose tolerance tests in nine patients off- and on-treatment with the anabolic steroid, methandienone (Dianabol). On-treatment, the tolerance tests showed a markedly increased insulin response accompanied by impairment of glucose tolerance, characteristics normally attributed to insulin resistance. However, fasting plasma glucose (FPG) and insulin (FPI) concentrations were significantly reduced, whereas the pattern normally associated with insulin resistance is for both to be raised. IVGTT glucose and insulin profiles were analysed using an algorithm derived from the minimal models of glucose and insulin dynamics originally proposed by R. Bergman and co-workers. Measures for the following parameters were thus obtained: Si, the sensitivity of glucose disposal to insulin; Sg, net insulin independent glucose disposal; phi 1, the integral concentration of insulin delivered during the first phase of insulin secretion relative to the initial increase in glucose concentration above a model-derived threshold; phi 2, the sensitivity of the rate of rise of insulin concentration in the second phase of insulin secretion to the concentration of glucose above a model-derived threshold; kappa, the fractional clearance rate of insulin; and tau 1/2, the insulin half-life. S1 was significantly reduced on treatment by a factor of 4. Sg, phi 1, phi 2 and tau 1/2 were all significantly increased, and kappa was significantly reduced. The increases in Sg and phi 1 both showed significant correlations with the increase in weight on-treatment. The reduction in FPG and FPI can be explained by the combined effects of the increase in Sg and Dianabol-induced resistance to glucagon.(ABSTRACT TRUNCATED AT 250 WORDS)

Insulin action and dynamics modelled in pati... [Clin Sci (Lond). 1986] - PubMed - NCBI
11-26-2012
DJM

Effect of methanedienone (methandrostenolone) on energy processes and carbohydrate metabolism in rat liver cells

Quote:

Abstract

It was found that methandienone administered through a gastric tube in daily doses of 1 mg/kg of body weight for 20 days induces significant changes in carbohydrate metabolism and in energy processes of the rat liver cell. Methandienone itself enhances glycogenolysis and anaerobic glycolysis, reduces cell respiration and does not affect the intensity and effectiveness of oxidative phosphorylation evaluated with succinate as a substrate. It is suggested that reduction of the cell respiration with concurrent enhancement of anaerobic glycolysis by methandienone seems to be the result of cell metabolism transposition on the oxygen-more-independent pathway.

[Effect of methanedienone (methand... [Farmakol Toksikol. 1981 Mar-Apr] - PubMed - NCBI
12-07-2012
burlyman30

Responses to sustained use of anabolic steroid.

Quote:

Shephard RJ, Killinger D, Fried T.

Abstract

Description is given of six body-builders who had been taking Methandrostenolone (up to 20 mg/day in intermittent courses for a year or more). At the time of examination there was no subjective disturbance of sexual function, but testosterone levels were low relative to laboratory standards and luteinizing hormone levels were also reduced - particularly in relation to testosterone concentrations. Abnormal liver function tests were seen in three of the six subjects, and one had mild diabetes with high serum cholesterol, triglycerides and uric acid. The weight gain of the group was not outstanding, and the only possible finding was a high haemoglobin and haematocrit in one of the six subjects.

PMID: 606318 [PubMed - indexed for MEDLINE] PMCID: PMC1859591

Full Text: Responses to sustained use of anabolic steroid.