Do you think that in the long run the rotation of the 21 herbs will also produce tolerance even if it is slower?

In our case, there is no other option than to jump into the void and try whatever it takes to recover our health, but for some reasons I am afraid of developing a tolerance to so many herbs and that in a few years none of these herbs will have an effect on me. There are those who resort to these herbs when they are 60 or 70 years old and they do not usually use as many and we are resorting to the most powerful much younger ones. Aren't you afraid that in the long run they will stop working? Those of you who have been with the rotation of the 21 herbs for a long time, do you notice that the effect is less?