huh... not unbearable large. I use 23s now, but 22s should be fine. I'm guessing it was only 1ml, so it shouldn't be that much material inside to cause a lot of PIP. Maybe it's the virgin territory rebelling against the first-time invader. I never really dealt with PIP much, so I don't have a ton of explanation for you. I'd just massage the area every so often and get the stuff to move on into the rest of your system.