Is saw palmetto shampoo risky?

[entropy]

It shouldn't be an issue if the SP acts locally rather then systemically.

But if it acts locally, it probably isn't the sp causing the regrowth.

[Cdsnuts]

But if it acts locally, it probably isn't the sp causing the regrowth.

Can 5ar not be just inhibited in the scalp topically? I know certain tissues have more or less of the enzyme depending on their function. We both know systemically is absolutely not the way to go.

[entropy]

It can be inhibited locally but its incredibly active all over the body, so I doubt it'd stop dht binding to the receptors in the scalp unless you occupied the receptors with some kinda anti androgen. (Keto, RU, Spiro etc). Personally I don't think its worth the risk really.

[Cdsnuts]

It can be inhibited locally but its incredibly active all over the body, so I doubt it'd stop dht binding to the receptors in the scalp unless you occupied the receptors with some kinda anti androgen. (Keto, RU, Spiro etc). Personally I don't think its worth the risk really.

I was under the impression that DHT dependent tissues got the hormone from 5ar in those tissues. Such that the conversion happened in the actual area in which it was needed. I'm obviously not an endocrinologist, but this is why blocking 5ar systemically is a bad idea. You starve ALL tissues of DHT. Again, I've been out of the loop on this stuff, happily, for the past couple years.

[entropy]

I was under the impression that DHT dependent tissues got the hormone from 5ar in those tissues. Such that the conversion happened in the actual area in which it was needed. I'm obviously not an endocrinologist, but this is why blocking 5ar systemically is a bad idea. You starve ALL tissues of DHT. Again, I've been out of the loop on this stuff, happily, for the past couple years.

I think -some- is, but it circulates in the bloodstream anyway, so it would make it to the scalp regardless. Think shedding from a dht prohormone.