When I ran 1-T topical, I felt none of the lethargy. That's because it had two ingredients of Dermacrine built in (pregenolone and 5-DHEA). When I ran 1-T Liqua-Vade, I got clobbered with lethargy. Felt like the flu. Sex drive was dead.
I'd suggest transdermal taken in conjunction with Dermacrine.