I've always been a little wary of stuff like dermacrine tbh. Its a little bit to far away the target hormones to be sure where it ends up, you know? Like, pregnenolone can easily become cortisol or even estrogen quite easily. And Dhea in men is much more likely to aromatise. I know they like to claim something about the enzymes in your skin converting primarily to androgens but the enzymes in your subcutaneous fat etc covert primarily to estrogen. Does that make sense or have I gone off on a tangent?