As I said before, increasing dopamine (caffeine, nicotine etc.) and increasing GABA can stimulate 5AR in the CNS. So it is not surprise that people improved on cocaine, GHB, ritalin, meth etc. however there are safer methods than using those substances.
That is why you take caffeine with a GABA agonist like niacinamide or glycine to help offset the GABA lowering while still getting the benefits of caffeine and even enhancing it further (glycine and niacinamide will increase 5AR in the CNS even further so they work in synergy)
Regarding the microdose LSD, just to prove the credibility, check this out. I'm not condoning it either, just since you brought it up.
LSD Microdosing: The New Silicon Valley Productivity Hack - YouTube