In the past its seemed to be mostly libido neutral. I've always stacked it with transdermal 4-DHEA so not sure if that helps offset anything underlying or not. However, I am on a current run where I am running it (Nor) higher than I have ever run it in the past just to see what limits I can push it to and I think I may be having some minimal side effects now. Before I ran it 300-400 mg/day and had good results with virtually no sides, I have now pushed it up to 700 mg/day and am noticing a slight dip in libido. Nowhere near what I have experienced in the past from 1-DHEA, just to give you a comparison.