Cistanche Tubulosa increases 5ar 2 gene expression 2-15 fold in the liver.

[Lookingforhelp]

interesting. how do you relate SHBG to liver though? I have high SHBG

SHBG is produced mostly in the liver. DHT is known to lower SHBG hence why more 5ar activity in the liver could possibly help. Personally when I trailed TRT for a few months not even exogenous Testosterone lowered my SHBG that much. Only by a few points...

I am just speculating to what 5ARI's could possibly do. High SHBG is an issue with me too and is one of the things that holds me back. I have good T numbers but my free androgen index is not great.


However, SHBG can be raised for various other reasons so again, just speculation.