Down to experiment?

[Right Hook]

I just saw this, but drinking gfj for two weeks would still leave a substantial amount of naringenin in your "system". I'm not sure for how long but there is pk research showing this compound accumulates in the body. It's not something that clears overnight that much I'm sure of. It's very likely to take at least a week or more.

Gfj/naringenin may not impact the metabolism of stano products (andro hard I think was stano?) as it's metabolized to stronger compounds via 17b-hsd Type 2 enzymes if I remember correctly.

It makes sense that it didn't mess with bbg's bolandiol cycle because diols are metabolized by 3b-hsd not 17b-hsd. So it may benefit that compound.

Tren I'm not sure on. I'd have to look at the structure.

[BBG]

It makes sense that it didn't mess with bbg's bolandiol cycle because diols are metabolized by 3b-hsd not 17b-hsd. So it may benefit that compound.

Excellent to know! Thank RH

[Right Hook]

A new piece of research popped up and it doesn't look good for naringenin and 3b-hsd either....

Biol Pharm Bull. 2013;36(2):228-37.
Effect of Polyphenols on Production of Steroid Hormones from Human Adrenocortical NCI-H295R Cells.
Hasegawa E, Nakagawa S, Sato M, Tachikawa E, Yamato S.
Source
Department of Bio-Analytical Chemistry, Niigata University of Pharmacy and Applied Life Sciences.
Abstract
Modulating steroid hormone levels is a curative and preventive measure for Cushing's syndrome, aldosteronism, and various stress-triggered symptoms. Polyphenols have been reported to inhibit steroidogenic enzymes such as 3β-hydroxysteroid dehydrogenase (3β-HSD) and aromatase. However, evidence for their inhibitory effects is fragmentary because it has been determined in studies with small groups of steroid hormones. To investigate the effects of steroids on complete steroidogenic pathways, comprehensive analysis of steroid hormones is necessary. Here we cultured forskolin-stimulated NCI-H295R, a human adrenocortical carcinoma cell line, in the presence of a polyphenol and employed GC-MS to simultaneously determine the levels of nine steroid hormones (pregnenolone, progesterone, deoxycorticosterone, aldosterone, 17α-hydroxyprogesterone, dehydroepiandrosterone, androstenedione, testosterone, and estradiol) in cell culture supernatant. We found that daidzein, genistein, apigenin, hesperetin, naringenin, and eriodictyol significantly reduced deoxycorticosterone and androstenedione levels (p<0.05), suggesting inhibition of 3β-HSD by these polyphenols. Apigenin was more potent than other polyphenols in increasing the levels of pregnenolone and 17α-hydroxyprogesterone, suggesting that it inhibits cytochrome P450 (CYP) 17 and CYP21, as well as 3β-HSD. Real-time reverse transcription polymerase chain reaction showed that apigenin significantly downregulated the expression levels of 3β-HSD, CYP17, and CYP21 mRNA (p<0.05). This is the first study to demonstrate the inhibitory effects of apigenin on CYP17 and CYP21.

For example, daidzein, genistein, apigenin, and naringenin inhibit 3β-hydroxysteroid dehydrogenase (3β-HSD).9–11) while daidzein and genistein inhibit cytochrome P450 (CYP) 21.12) In addition, isoflavones inhibit both 3β-HSD
and 17β-hydroxysteroid dehydrogenase (17β-HSD).13

Accordingly, we tested the effects of polyphenols on steroido-
genic pathways by simultaneously measuring levels of nine
steroid hormones. We found that isoflavones (daidzein and ge-
nistein), one flavone (apigenin), and three flavanones (hesper-
etin, naringenin, and eriodictyol) dose-dependently decreased
the levels of androstenedione and deoxycorticosterone pro-
duced by forskolin-stimulated NCI-H295R cells, suggesting inhibition of 3β-HSD. These inhibitory effects were in good 9 –11)
agreement with the results of previous studies.


Comprehensive understanding of steroidogenic pathways is important to understand the actions of pharmaceutical agents
inhibition of 3β-HSD. These inhibitory effects were in good 9 –11)
agreement with the results of previous studies.

[O_RYAN_007]

Haha. Fukin bone daddy. I really wish we could all meet up, sit down and
Just hang out. A swole source meet up would be pretty gangster.

But back on topic, TAKE THAT right hook. Lol

I tell my wife about all you crazy fuckers, a meet up would be cool as shit!

[O_RYAN_007]

How would gfj effect the effects of say var/test/or proviron? I know pro and ah have very similar molecular structures.

[BBG]

A new piece of research popped up and it doesn't look good for naringenin and 3b-hsd either....

But my placebo effect...




- - - Updated - - -

Yes a meet up... but I'll need time to get huge.

[nate3993]

How would gfj effect the effects of say var/test/or proviron? I know pro and ah have very similar molecular structures.

very curious about this. underlined especially

[burlyman30]

I tell my wife about all you crazy fuckers, a meet up would be cool as shit!

Mentally compromised, deficient, or unstable, personality disorders, and unpredictable behaviors... but please dont use the word crazy....

[Cobalt]

A meet up would be cool... at my place.

[Turbo6GN]

I'll give this a go, I just ordered my Alpha Mass and Stano. I'll be adding derm as well. I will take it with 4-5oz of gfj daily (enough to wash down the pills) and report anything I think will interest you guys. Unfortunately I have nothing to draw a comparison from but I'm kinda curious myself. The return of the dreaded gfj burps...oh joy!!