This was on another board - a summary of chlomiphene studies
Here are some of my findings in brief. Remember, I'm not a doctor or anything. But this is what I make of the studies:
•The most common dose in the studies is a tie for 25 mg Every other day or 50 mg Every other day. Some studies also do 25 mg/day or 50 mg/day.
•Within the doses used in the studies, the results appear to vary little (For example, two studies that prescribed either 25 or 50 mg every other day gave the EXACT same % of total Test improvement as the study that prescribed 25 mg/day in all cases). The average testoterone level post-treatment is about 250% of baseline across the board. Remember, though, that most of the baselines are below normal or low-normal.
•All the studies consistently report that nobody reported any side effects, with the exception of 1 subject in 1 study who reported visual disturbances that went away when he got off of it. Other than that, zero (so well under 1% with any reported sides at all across these studies).
•Studies that included questioning about subjective relief of low-T symptoms (sexuality, energy, etc) yielded good results. Typically these complaints were approximately cut in half with treatment (that is, they were reported half as often after treatment).
•Younger patients tended to have better results than the older ones.
•One study noted that the presence of a varicocele did not influence the results of clomid treatment in their study one way or the other.
•Clomid's results are sustained with prolonged use, with a possible small dip at around the 2 year mark that doesn't look like it goes any lower (this is noted in one long-term study but not the other). A couple of these look at subjects who have used it for years (up to 3 I believe) and the results and lack of sides do not appear to change.
•In none of the studies at any dosage was the Testosterone elevated above the normal range.
•Testosterone can be raised in as little as 1 week. Generally it's accepted that clomid raises things within 4-8 weeks. Results in symptoms may take longer but at least something should happen within that time frame IMO (one study I read about TRT in general marked 3 weeks as the beginning of improvements in symptoms).
•Two of the studies measure Free testosterone (the others use only Total). The results there get are a little confusing. Their numbers are wildly different (the post-treatment Free in one marks the beginning of the pre-treatment in the other). Not sure what's going on there. Maybe I am misunderstanding the units. But it does increase Free T significantly in both studies (at least double on average).
The link has a zip file of the articles themselves
Every Full-Text Clomid Study You've Ever Wanted (also share your experiences!)