Quote Originally Posted by Freepressright View Post
Good, when you dose it around 4 RDE tabs per day. And that's a lot of mint and Altoids. Personally I got so sick of dosing it that I decided not to grab a second bottle.

I'll back up Nate on the criticism of their delivery system. It's good, but it isn't THAT good. In other words, the stuff works but not as well as they claim with that super-impressive-sounding percentage.

Also, they call them "Rapid Dissolve" tabs, and that's an exaggeration. There's nothing rapid about them. It's slightly better with the effervescent stuff added, but it's still not rapid.

Go Stano, bro

I'm going to run Stano Elite at 800+ per day next time around
Which percentage? When you say "they" that's me. The 30%? That's based on the available literature that supports the claim and nothing more. There is no accurate or remotely usable way to measure anecdotal experience. Its subjective. Data however is objective. So thats why i use.

I used the conservative claim as well. I could have said (300%) as most other companies would. I don't know why you guys hate me so much.

Why we use 30%:

First in 2010 research was published out of Cairo University that developed and compared an orally disintegrating tablet (including hydroxyl propyl beta cyclodextrin, and an effervescent matrix) to a regular oral supplement (1). The supplement is a popular nootropic known as vinpocetine, used to enhance memory and also sold as a drug to treat stroke victims (caviton). Vinpocetine, like prohormones is poorly water soluble and is rapidly broken down by first pass metabolism and for this reason they felt an orally disintegrating tab would improve the pharmacokinetics. And they were right. They found that the orally disintegrating tab utilizing an effervescent matrix resulted in a 306% increase in bioavailability!

Therefore we looked to a patent filed in 2008 (2). What is great about this patent are the research and the compound they studied. The compound is known as progesterone, which is used in hormonal replacement therapy for women. Of course we don’t want to supplement progesterone, but much like prohormones progesterone is a sex steroid, which makes it poorly soluble in water. And just like prohormones progesterone has a poor bioavailability (6-8%) when administered orally (3). The inventors were trying to better an existing orally disintegrating formulation which consisted of progesterone, HPCD, as wells as other basic ingredients such as flavoring. So they created the same formula, with the addition of an effervescent matrix (citric acid, and sodium bicarbonate). With the two formulations they then completed a pharmacokinetic study using each formulation which contained equal amounts of the studied active (in this case progesterone). As you can see below there was a significantly greater spike in “Example 2” which contains the effervescent matrix.



In the graph above it doesn’t appear much different from “Example 1”, however when you factor in the all important area under the curve (AUC) you would find a bioavailability increase of 30%. And this is why Advanced Muscle Science believes you will see a similar increase in bioavailability with the new line of effervescent matrix enhanced prohormones.

The Lab: Effervescent Elitism - AMS Rapid Dissolve Tabs