User Tag List

Results 1 to 3 of 3
  1. #1
    Super Moderator Feedback Score 3 (100%) BBG's Avatar
    Join Date
    Nov 2012
    Posts
    1,489
    Mentioned
    2 Post(s)
    Tagged
    0 Thread(s)
    Androgen hormone binding to adipose tissue in rats.

    Biochim Biophys Acta. 1995 May 11;1244(1):117-20.
    Androgen hormone binding to adipose tissue in rats.

    Sjögren J, Li M, Björntorp P.

    Source

    Wallenberg Laboratory, Department of Heart and Lung Diseases, University of Göteborg, Sahlgren's Hospital, Sweden.

    Abstract

    Nuclear binding of androgen was examined, using R 1881, a synthetic androgen. The amount of androgen-receptor complexes bound to isolated nuclei was determined in isolated adipocytes from the epididymal (Epi), retroperitoneal (Ret), inguinal (Ing) and mesenteric (Mes) adipose tissues from intact and castrated rats. The binding was specific and saturable with a Kd in the nanomolar range. Binding was examined after 2 days and after 1 and 2 weeks after castration, showing a higher binding in the Mes tissue in comparison with Ing at all time-points (P < 0.05). Mes adipocytes showed a trend (0.05 < P < 0.1) to up-regulate their binding capacity 2 days after castration, and a significant (P < 0.05) downregulation 2 weeks after castration. Two days after castration, R 1881 binding, expressed per mg triacylglycerol (TG), was generally higher in the Mes region (P < 0.05). This was not fully significant in comparison with Epi tissue in intact rats. When expressed per cell the differences were somewhat diminished, due to differences in cell sizes. Androgen binding showed a negative correlation with TG-uptake in vivo (r = 0.85, P < 0.01), suggesting that a higher density of androgen receptors leads to a more inhibited lipid uptake. In conclusion, a specific androgen receptor was demonstrated in adipose tissue in rat, showing regional differences and a negative correlation with the lipid accumulation of the tissue.
    Androgen hormone binding to adipose tis... [Biochim Biophys Acta. 1995] - PubMed - NCBI
    Last edited by h2s; 11-13-2012 at 09:09 AM.
    Super not-not-moderator BBG

    Need extra cash? List of "Get Paid To" sites: Make $5 a day

  2. #2
    Super Moderator Feedback Score 0 burlyman30's Avatar
    Join Date
    Nov 2012
    Location
    Oregon
    Posts
    2,617
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Androgens [General]

    Effect of non aromatizable androgens on LHRH and TRH responses in primary testicular failure.

    Spitz IM, Margalioth EJ, Yeger Y, Livshin Y, Zylber-Haran E, Shilo S.

    We have assessed the gonadotropin, TSH and PRL responses to the non aromatizable androgens, mesterolone and fluoxymestrone, in 27 patients with primary testicular failure. All patients were given a bolus of LHRH (100 micrograms) and TRH (200 micrograms) at zero time. Nine subjects received a further bolus of TRH at 30 mins. The latter were then given mesterolone 150 mg daily for 6 weeks. The remaining subjects received fluoxymesterone 5 mg daily for 4 weeks and 10 mg daily for 2 weeks. On the last day of the androgen administration, the subjects were re-challenged with LHRH and TRH according to the identical protocol. When compared to controls, the patients had normal circulating levels of testosterone, estradiol, PRL and thyroid hormones. However, basal lh - leutenizing hormone - , FSH - follicle stimulating hormone - and TSH levels, as well as gonadotropin responses to LHRH and TSH and PRL responses to TRH, were increased.

    Mesterolone administration produced no changes in steroids, thyroid hormones, gonadotropins nor PRL.

    There was, however, a reduction in the integrated and incremental TSH secretion after TRH.
    Fluoxymesterone administration was accompanied by a reduction in thyroid binding globulin (with associated decreases in T3 and increases in T3 resin uptake). The free T4 index was unaltered, which implies that thyroid function was unchanged.

    In addition, during fluoxymesterone administration, there was a reduction in testosterone, gonadotropins and lh - leutenizing hormone - response to LHRH.

    Basal TSH did not vary, but there was a reduction in the peak and integrated TSH response to TRH. PRL levels were unaltered during fluoxymesterone treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
    Effect of non aromatizable androgens on LHRH ... [Horm Metab Res. 1984] - PubMed - NCBI
    All advice given is for entertainment value only. And it's free. Take it for what it's worth.

  3. #3
    Super Moderator Feedback Score 0 burlyman30's Avatar
    Join Date
    Nov 2012
    Location
    Oregon
    Posts
    2,617
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)
    Anabolic steroids have long-lasting effects on male social behaviors.

    Salas-Ramirez KY, Montalto PR, Sisk CL.

    Source
    Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA. ksalasram@ccny.cuny.edu

    Abstract

    Anabolic androgenic steroids (AAS) use by adolescents is steadily increasing. Adolescence involves remodeling of steroid-sensitive neural circuits that mediate social behaviors, and previous studies using animal models document effects of AAS on male social behaviors. The present experiments tested whether AAS have persistent and more pronounced behavioral consequences when drug exposure occurs during adolescence as compared to exposure in adulthood. Male Syrian hamsters were injected daily for 14 days with either vehicle or an AAS cocktail containing testosterone cypionate (2 mg/kg), nandrolone decanoate (2 mg/kg), and boldenone undecylenate (1 mg/kg), either during adolescence (27-41 days of age) or adulthood (63-77 days of age). As adults, subjects were tested two or four weeks after the last injection for either sexual behavior with a receptive female or male-male agonistic behavior in a resident-intruder test. Compared with vehicle-treated males, AAS-treated males, regardless of age of treatment, displayed fewer long intromissions and a significant increase in latency to the first long intromission, indicative of reduced potential to reach sexual satiety. Increased aggression was observed in males exposed to AAS compared with males treated with vehicle, independently of age of AAS treatment. However, unlike hamsters exposed to AAS in adulthood, hamsters exposed to AAS during adolescence did not display any submissive or risk-assessment behaviors up to 4 weeks after discontinuation of AAS treatment. Thus, AAS have long-lasting effects on male sexual and agonistic behaviors, with AAS exposure during adolescence resulting in a more pronounced reduction in submissive behavior compared to AAS exposure in adulthood.

    Published by Elsevier B.V.

    PMID: 20036695 [PubMed - indexed for MEDLINE] PMCID: PMC2831157

    Full Article: ANABOLIC STEROIDS HAVE LONG-LASTING EFFECTS ON MALE SOCIAL BEHAVIORS
    All advice given is for entertainment value only. And it's free. Take it for what it's worth.

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •