19-nor dhea (mg) ?

[Right Hook]

yeah. lol to someone saying that topical plain DHEA wasn't as effective as oral. the skin enzymes yielded much higher conversions to the androgenic hormones than oral. with oral plain DHEA you're prolly gonna just get more estrogen than anything else. at least i know that high dose oral dhea gives you a large estrogen increase.

and just so you know, i'm only talking about plain DHEA. not 1-dhea. not 5-dhea. just plain, jane DHEA.

Who said that? Not I.

[Freepressright]

yeah. lol to someone saying that topical plain DHEA wasn't as effective as oral. the skin enzymes yielded much higher conversions to the androgenic hormones than oral. with oral plain DHEA you're prolly gonna just get more estrogen than anything else. at least i know that high dose oral dhea gives you a large estrogen increase.

and just so you know, i'm only talking about plain DHEA. not 1-dhea. not 5-dhea. just plain, jane DHEA.

5-DHEA is plain DHEA

[Sperwer]

It is an absolute crime that no one has ever developed a topical 19norDHEA. This hormone in particular would be delivered exceptionally well with a topical carrier. The enzymatic conversion would be highly efficient.

This is really an overlooked prohormone that no one has really developed or polished upon. PP did with AndroBulk, but it enjoyed relatively little recognition in the short timeframe it was available. Hopefully someone else will run with this one some day.

Stay tuned!


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[nate3993]

5-DHEA is plain DHEA

4-dhea is what i meant.

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and right hook, you're correct. i misread

[Freepressright]

Stay tuned!


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This is the kind of thing I like to hear!

[Sperwer]

This is the kind of thing I like to hear!

What do you guys think about transdermal patches as a possibility. They are quite common here as a delivery system fir everything from simple analgesics to very sophisticated cancer drugs. They are minimize the buttered toast effect and if you are a little flexible open the possibility of using your back and thus significantly enlarging the effective application area, without having to involve someone else. My designated OEM is a bit of a specialist in this area and we now are exploring delivery effectiveness and price feasibility for some compounds. The only downside i see is having to "wear" one for a number of hours. Having lived here a long time and gotten used to it myself, it's a no brainer to me. But others may feel differently. Comments?


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[milehighguy]

How long would you wear the patch? What type of compounds are you talking about?

I don't see why not. Do we know the effectiveness of the delivery via a patch?

[Sperwer]

How long would you wear the patch? What type of compounds are you talking about?

I don't see why not. Do we know the effectiveness of the delivery via a patch?

Good questions. We are working on the assumption that effectiveness has to be as good as TD cream or gel, and will be testing for that. Time on target similarly will be no more than the 5-6 hours currently recommended for eg Dermacrine, Sustain A, AndroEnhance, etc - less if we can engineer it. Potential candidate compounds include pretty much everything formerly in PP's repertoire


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[Grape Ape]

How large of a patch?

[Sperwer]

How large of a patch?

Another good question; also to be determined as required by the size necessary to facilitate TD delivery of the target dosages. A LOT larger than youe average bandage, that's for sure, even pushing 6x6 in some instances.

QUESTION IS: WOULD PEOPLE PREFER THIS TO REGULAR TD CREAM/GEL APPLICATION, LET ALONE GELCAP, ASSUMING SUPERIOR DELIVERY OF BIOAVAILABLE DOSES AT A COMPETITIVE PRICE