Pharmacology of anabolic steroids

[Jelisej]

Link: Pharmacology of anabolic steroids

Nice read; nice graphs showing of:
-how testosterone binds to androgen receptor
-structure of some of aas
-Catalytic hydrogenation of gestrinone to form tetrahydrogestrinone
-Intracellular metabolism and the myotrophic–androgenic index of some aas
-Non-steroidal AR agonists

some interesting points:
"With respect to prohormone supplements of testosterone, as recently reviewed by Brown et al. (2006), these are modelled on steroids that are endogenously produced, that is, androstenedione, androstenediol and DHEA. However, supplements of the weaker androgens DHEA or androstenedione may be of little or no benefit to healthy young men who wish to improve their strength and sporting performance"

"This mechanism of myotrophic–androgenic dissociation does not explain why other anabolic steroids that do not undergo 5α-reduction, for example, those with an extra double bond in the A-ring, such as chlorodehydromethyltestosterone and methandienone (Schanzer, 1996), have a favourable mytotrophic–androgenic index. Even so, it is possible that that myotrophic–androgenic dissociation may occur, simply because the effect of the particular steroid cannot be amplified by 5α-reduction in androgenic target tissues, in common with the hypothesis proposed for the differential action of a steroidal SARM"

Another link: Anabolic androgenic steroids: what the psychiatrist needs to know