I personally found that letro did nothing for my pre-existing gyno. when I temporarily ran out of ralox, I was up to 2.5mg ED of letro and I swear it was getting worse. so I dropped the letro completely (after tapering) and it seemed to respond better to just plain ralox.
the gyno developed in a compromised hormonal environment, so I dunno if lowering estro after the fact will do much. I'm gonna be trying a 4 month run of AndroHard coming up pretty soon here (soon as PP resurrection happens) so we'll see