For me, it's really necessary to add stano to avoid gyno (for me of course). I stopped it during few days 'cause Stano makes me piss each night, but I immediately felt a little burn on my nipples and it was increasing each day. I re-started to take Stano (1200mg/day) and pain/burn feeling disapeared after 2 days. No pain, no burn feeling, no gyno now (for information I take Anastrozole @0.25mg E3D)
No placebo effects I'm certain.