Originally Posted by
Jelisej
i m reading the article and have some questions bro:-
Q:1-we know the guy had low test levels when he visited the doctor, but was his E2 also high? or did the E2 go up when he used clomid?
A:Was his E2 high? Probably. Well, "body" point of view was that it was high- tough "body" gets message through receptors, so if receptors are messed up "body" gets wrong info, so sometimes guys may not have really high estrogen levels tough usually in this kind of scenario guys do have high estrogen levels.
Sometimes in later stages even estrogen levels drop along with test. levels so person has both low test. and estrogen.
Obviously there are other conditions where estrogen levels are low, but these are different scenarios.
In you particular case scenario is most likely to be similar to those guys, tough some other problem can become transparent- for example you may have some other condition or even your adrenals may be underperforming which would result in lot of aromatisation.
Q:2- I am completely confused with this paragraph:-"Estrogen Receptors in the Hypothalamus Control the Whole Thing
in this paragraph it is written tht in males the estrogen receptors(did u mean testosterone receptors) controls the LH and FSH production and by clomid v can block this estrogen receptor in the hypothalamus right?? BUT if estrogen receptors are producing LH and FSH then y block it ???and first it says clomid will block the receptor that controls the production of LH n FSH and then it says it will stimulate the hypothalamus which in turn stimulates pituitary which stimulates LH n FSH production i m so confused with this ??
OR by, estrogen receptor controlling LH n FSH we mean tht HIGH LEVELS OF ESTROGEN controls or slows down the production of LH n FSH ?? and so when we take clomid we block the estrogen receptor which will lower the estrogen?
A:"Estrogen Receptors in the Hypothalamus Control the Whole Thing"- this is so clearly and well said, that I dont understand what is confusing you.
When you block estrogen receptors (in brain), body thinks that there is no estrogen so it raises LH. Other good thing is that receptors become more sensitive, and thus more effective.
Obviously, as testosterone levels raise estrogen will as well (via aromatise) but thats why we use some AI among other stuff.
Remember- estrogen in men is made from testosterone via aromatise, so in order to raise estrogen body has to raise testosterone (via LH). Body itself is more interested in estrogen than in testosterone.
Q:3:- we know when we take exogenous test, the excess test also causes the HPTA to stop releasing GNRH- wat we call shut shut down when v do a cycle ! does high estrogen also signals Hypothalamus to stop producing GNRH?? does this mean both high test and high E2 shuts us down??
A: E2 is main trigger for hypotalamus, tough other hormones play role as well but not as much and it depends from person to person- for example even if person use only DHT it is going to slow down testosterone production or even stop it completely, but generally at much slower rate (depending on may factors)
DHEA has ability to convert to E2 as well, for some folks more than for others, and it can sometime activate some estrogen receptors... Anyway there are lot of mechanism we dont know much about.
As for lowering E2, I would say same thing as for vit D- it goes along with, clomid restart, you may start AI first but not neccessary. Now dosage of AI is tricky bit, different people need different doses. In any case, clomid should be used for sake of sensitation of receptors.