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  1. #1
    Sponsor Feedback Score 0 O.N.'s Avatar
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    SEDDS Sustain Alpha Liquid Replacement

    A New Journey Begins!
    For over a year now Wicked Supplements has been in back and forth consultation and testing with several pharmaceutical giants. Yes that may sounds strange. How does our company get a foot in the door with these people?

    Well really it just came down to knowing the right people for a very long time and allowing us to be fast tracked through the chain of command of different subsidiary companies of the major companies and of course.....money.
    Many discussions, in depth thought, 100's of back and forth testing and especially funds have gone into this project for the future of this system.

    We have had the privilege to work along side many great minds from the USA, Europe and Australia. To create a highly bio available self emulsifying drug delivery system (SEDDS).

    Absorption & Delivery
    The key problems faced with almost every dietary ingredient or drug is absorption they will all degrade to some degree during digestion and some will struggle to deliver enough active ingredient to cause the desired results, this is exactly where a SEDDS can be used.

    SEDDS (self emulsifying drug delivery systems) are the absolute way of the future!
    There are several key components to a SEDDS. I wont go into too much detail but basically we and several pharmaceutical scientists started with what info we had previously obtained from several other drug and supplement formulations and then worked backwards, we went over the what, the hows and the whys? on each and every component. We have conducted countless numbers of tests to validate data.

    We have found evidence of a drug currently sold which shows detailed information through minor modifications to different aspects of the SEDDS formula to be able to begin with a starting point of an 1100% increase in delivery versus a powdered tablet and then to further enhance this system to be 1150% and then with even further tweaks end up with a final SEDDS formulation at a 1200% increase in delivery vs powdered tablet. That is for a current drug used in the medical industry right now. Information like this shows us how small modifications in the right areas of a SEDDS are possible to keep pushing delivery percentages higher and higher.

    The End Result
    After all this planning, consulting, testing, spending thousands of dollars and hundreds of hours we have a SEDDS formula. It certainly works and far exceeds what we thought was possible.....whats the percentage increase?....the answer is 500-800% increase of poorly soluble ingredients and 1000+% of highly soluble ingredients.

    How a SEDDS work
    The simplest way to understand it would be an entrapment of the active ingredients in the SEDDS. The stomach cannot break down the actives as they are protected in the SEDDS and you can achieve a delivery of your actives intact and ready for absorption.

    Once in the digestive tract the SEDDS sticks to the digestive walls and starts forcing the active ingredients into the walls at higher concentrations than normal powdered form, allowing for massive increases in the percentage of delivery.

    What About The Taste?
    Some of you may remember that bitter after taste from previous SEDDS formulas that has been altered to be much more tolerable with the help of some great people which have helped to flavor many different oral medications currently sold in today's market.

    When do i expect this to be ready? 1-2 months but when it's out watch out it will literally deliver!

    If you have any questions please ask away
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  2. #2
    SwoleSource Member Feedback Score 0
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    "We have conducted countless numbers of tests to validate data."

    Care to describe the test types ? in a lab dish, rats, humans....

  3. #3
    Moderator Feedback Score 0 Cdsnuts's Avatar
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    Sounds like something that could exacerbate or increase leaky gut problems for susceptible individuals, people with auto-immune issues. Does it literally force the target ingredient through the gut wall or carry it over to be absorbed properly?
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  4. #4
    Established Member Feedback Score 0 markam's Avatar
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    The End Result
    After all this planning, consulting, testing, spending thousands of dollars and hundreds of hours we have a SEDDS formula. It certainly works and far exceeds what we thought was possible.....whats the percentage increase?....the answer is 500-800% increase of poorly soluble ingredients and 1000+% of highly soluble ingredients.

    Curious as to exactly who spent the thousands of dollars, surely not wicked supplements

    So I'm guessing the tests weren't with the sustain alpha product, just the SEDDS delivery system. Be interesting to see what side effects if any, were caused buy using SEDDS with Sustain Alpha. Was the product or just the delivery system tested?

    Edit....Don't mean to sound like I'm bashing the product, it may well be brilliant, for all I know, (and that's not much )
    Last edited by markam; 03-05-2014 at 07:59 AM.

  5. #5
    Sponsor Feedback Score 0 O.N.'s Avatar
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    Quote Originally Posted by mahatma View Post
    "We have conducted countless numbers of tests to validate data."

    Care to describe the test types ? in a lab dish, rats, humans....
    We looked into the efficiency of oral absorption of several drug compounds with the SEDDS formula. It all depends on many related parameters, such as surfactant concentration, oil/surfactant ratio, droplet size and charge, polarity of the emulsion, all of which will determine the self emulsification ability. Only very specific pharmaceutical excipient combinations will lead to efficient self emulsifying drug delivery systems.

    Being able to work with the scientists we were able to examine in depth 4 current SEDDS medications, how and why they worked the way they do.

    We were also able to look at a lot of previous study data others have completed with different drugs and supplements from Progesterone to CoQ10 and even tocotrienols. From this study data being able to compare about 20 different formulas gave the ability to see how and where improvements were seen.

    For instance a study from the drug Ontazolast it is an asthmatic drug with 4 different variations to the SEDDS formulation we can see an improvement of 800%, 1100%, 1300% and 1500% and you can see the AUC improve also from AUC0-8 hr = 528±68 h ng/mL to AUC0-8 hr =1003±270 h ng/mL

    As you can see being able to see so many different formulations is a huge advantage.

    We have completed an 18 person trial for toxicology safety data which ran for 30 days comprised of before, during and after blood tests mapping parameters such as liver function, blood pressure etc all persons passed with no issues at all and everybody also completed self reporting daily for anything from headaches to upset stomachs, diarrhea, nausea etc again there were no issues in all 18 participants.

    We are very proud of this although the study group is small in scale a great deal of time was spent in getting everything perfect, this is one of the reasons it has taken over a year and I have not said one word about this on the internet until today. This was certainly not a case of quick lets rush things and make a product to start selling.


    Quote Originally Posted by Cdsnuts View Post
    Sounds like something that could exacerbate or increase leaky gut problems for susceptible individuals, people with auto-immune issues. Does it literally force the target ingredient through the gut wall or carry it over to be absorbed properly?
    See above in regards to stomach etc, yes the SEDDS force active ingredients through biological membrane such as the mouth, esophagus and intestinal surfaces.


    Quote Originally Posted by markam View Post
    The End Result
    After all this planning, consulting, testing, spending thousands of dollars and hundreds of hours we have a SEDDS formula. It certainly works and far exceeds what we thought was possible.....whats the percentage increase?....the answer is 500-800% increase of poorly soluble ingredients and 1000+% of highly soluble ingredients.

    Curious as to exactly who spent the thousands of dollars, surely not wicked supplements

    So I'm guessing the tests weren't with the sustain alpha product, just the SEDDS delivery system. Be interesting to see what side effects if any, were caused buy using SEDDS with Sustain Alpha. Was the product or just the delivery system tested?

    Edit....Don't mean to sound like I'm bashing the product, it may well be brilliant, for all I know, (and that's not much )
    We had several bottles of sustain alpha to test during the trial, as this product was the initial inspiration to create the system, we were able to replicate the formula to the exact percentages of all 23 ingredients contained, however it did have some very major inefficiencies and it also had some negative effects within the body since several unnecessary ingredients were being used such as 190 proof alcohol. As for which parameters of this formula are inefficient I will not discuss as this may only lead to other companies reviewing and fixing their formula if re-released in the future. However I can say there were several problems.

    This project was self funded along with government assistance for university student research. Hence why we will also be having a human trial in a few months time at the University of NSW as mentioned a couple of days ago on the forum.
    Last edited by O.N.; 03-05-2014 at 10:32 AM.
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  6. #6
    Sponsor Feedback Score 0 O.N.'s Avatar
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    We have completed a couple of user based tests this week.

    We have had some pre workout testing this week on 3 users taking different pre workout supplements simply taken in conjunction with the SEDDS, all 3 reported the pre workout kicked in faster, it lasted much longer and was also a lot stronger in action, 2 of the 3 reported that they normally have a buzz for a couple of hours, however it lasted much longer 2 of them claimed they were unable to sleep normally falling asleep around 11pm but not able to get off to sleep until 6-7am the next day.

    This was not dissolved into the SEDDS it was simply taken at the same time, showing how efficient the SEDDS is in terms of action, we really wanted to use something like a pre workout where the effects are felt very easily.

    All 3 people took their normal doses that they used and compared the results to what they normally feel. 2 guys were using scivation psycho and the 3rd was using an old tub of craze that he had.

    So I guess the next question is what type of products do you guys want to see in the SEDDS
    Last edited by O.N.; 03-21-2014 at 09:01 PM.
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  7. #7
    SwoleSource Member Feedback Score 0
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    I think it would be interesting to

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  8. #8
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    Final sample batch today being sent off for analysis

    Photo0016.jpg
    Last edited by O.N.; 03-31-2014 at 08:14 AM.
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  9. #9
    A 1k Club Member Feedback Score 1 (100%) nate3993's Avatar
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    Sounds very interesting and cutting edge. Congrats on being able to do a university study.

  10. #10
    Super Moderator Feedback Score 3 (100%) BBG's Avatar
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    Would this be something that could be sold separately, and we could then mix our own ingredients into it?
    Super not-not-moderator BBG

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