Prohormone and Designer Steroid Profiles

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Dienolone

Structure:


Nomenclature:
17β-hydroxyestra-4,9(10)-dien-3-one or
19-norandrosta-4,9(10)-dien-17β-ol-3-one

Current Clones (Brand Names):
Iron Legion Dienazone (topical product)

Anabolic/Androgenic Ratio:
140:43-83 vs methyltestosterone by oral administration.

History:
Dienolone was first synthesized by researchers at Eli Lilly in 1960. It was first sold as a topical product by Antaeus Labs as "Trenazone" in 2010.

Structure and Function:
Dienolone is a nandrolone derivative, differing only by unsaturation (a double bond) at C9-10. This conjugated system increases stability, flexibility, and reduces receptor specificity.

Testosterone, DHT, or 19-nortestosterone based? 19-nortestosterone based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking, strength, and recomp
Typically dosed at: 75-150mg for six weeks (topically)

Links:
Dienolone (Trenazone) Bible - TunedSports.com
Estra-4,9-diene-17b-ol-3-one (Dienolone): What is it?

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Promagnon

Structure:


Nomenclature:
4-chloro-17α-methyl-androst-4-ene-3,17β-diol, or
4-chloro-17α-methyl-17β-hydroxy-androst-4-en-3-ol

Synonyms:
P-Mag

Current Clones (Brand Names):
Hard Rock Pro-Mag 25

Anabolic/Androgenic Ratio:
Unknown

History:
This compound was first released as "Promagnon 25" from Peak Performance Labs in 2005.

Structure and Function:
P-Mag is a methyltestosterone derivative, differing in that it has a 4-chloro substituent, and a hydroxyl at the 3 position. Promagnon is understood to be a pro-drug to methyl-clostebol (via the 3bHSD enzyme).

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking, and recomp
Typically dosed at: 75-125mg for four to six weeks

Links:
The Promagnon/P-mag Bible - TunedSports.com
4-chloro-17a-methyl-androst-4-ene-3b,17b-diol (Promagnon): What is it?

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Methyl Clostebol

Structure:


Nomenclature:
4-chloro-17α-methyl-17β-hydroxy-androst-4-en-3-one, or
4-chloro-17α-methyl-androst-4-en-17β-ol-3-one

Discontinued Clones (Brand Names):
Antaeus Labs Mechabol

Current Clones (Brand Names):
Celtic Labs Celtibol, Androgenetx Mecha Drive, Anabolic Technologies Xtreme H-50, IronFlex Supplements: Mbol-25

Anabolic/Androgenic Ratio:
50:10-15 vs. methyltestosterone by oral administration.

History:
The activity of methyl clostebol was examined by researchers at Sterling Winthrop in the 1960s. There's also some evidence that methyl clostebol was experimented with by the East German doping machine, under the moniker STS 482. Methyl Clostebol was first released as a dietary supplement called Mechabol by Antaeus Labs.

Structure and Function:
Methyl clostebol differs from methyltestosterone by the addition of a 4-chloro atom at C4. This substituent will prevent aromatization, and likely hinders reduction of the delta-4 double bond.

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking, recomp
Typically dosed at: 75-125mg for six weeks

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Epistane

Structure:



Nomenclature:
2a,3a-epithio-17a-methyl-17b-hydroxy-5a-androstane, or
2α,3α-epithio-17α-methyl-17β-hydroxy-5α-androstane

Current Clones (Brand Names):
Celtic Labs Epistane, IronFlex Supplements Brawn, LGI Epi-10

Anabolic/Androgenic Ratio:
1100:91 vs methyltestosterone by oral administration.

History:
Epistane was first synthesized by G.D. Searle & Co in 1966, building on research by Shionogi in Japan. It was first released as a supplement by IBE as "Epistane" and RPN as "Havoc" in 2006.

Structure and Function:
Epistane is a DHT derivative with a heterocyclic episulfide moiety at carbons 2 and 3. It has a 17a methyl function for oral bioavailability.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Lean bulking, cutting, and recomp
Typically dosed at: 20-60mg for four to six weeks

Links:
The Epistane & Havoc Informative Bible - TunedSports.com
Epistane profile - Primordial Performance
2a,3a-epithio-17a-methyl-17b-hydroxy-5a-adrostan (Epistane): What is it?

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2-Androstenol

Structure:



Nomenclature:
17b-hydroxy-5a-androst-2-ene, or
5a-androst-2-en-17b-ol

Synonyms:
desoxytestosterone, unmethylated-phera

Current Clones (Brand Names):
PHF Supplements Desoxy T Acetate powder (as acetate ester)

Anabolic/Androgenic Ratio:
Unknown

History
2-androstenol is a naturally occurring compound. It was first synthesized, and its biological activity assayed, by Syntex researchers in 1962. 2-androstenol acetate was first sold as a supplement as a component of Anabolc Xtreme's 3-AD.

Structure and Function:
2-androstenol is a DHT derivative. It is unsaturated (has a double bond) at C2-3. It can be considered the non-17a-methyl analog of desoxymethyltestosterone, or "unmethylated pheraplex".

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Stacking, bulking, lean bulking
Typically dosed at: 50-100mg for four to six weeks

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Adrenosterone

Structure:



Nomenclature:
Androst-4-ene-3,11,17-trione

Synonyms:
11-oxo, , 11-oxo-androstenedione, 11-keto-androstenedione, Reichstein's Substance G

Current Clones (Brand Names):
Smart Powders 11-Lean, LGI 11-X, Androgenetx A-Dren 100

Anabolic/Androgenic Ratio:
Unknown

History:
Adrenosterone is a naturally occurring hormone, first isolated in 1936 by Nobel prize-winning Swiss chemist Tadeus Reichstein. It was first sold as a supplement by Patrick Arnold as ErgoPharm "11-oxo".

Structure and Function:
Adrenosterone is a selective inhibitor of the reductase activity of the cortisol-activating enzyme 11β-HSD1. It is also a prohormone to the active androgen 11-ketotestosterone.

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Lean bulking, recomp, cutting
Typically dosed at: 300-1000mg for four to six weeks

Links:
The 11-OXO (Adrenosterone) Bible - TunedSports.com
Androst-4-ene-3,11,17-trione (Adrenosterone): What is it?

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Methyl-1-Androstenediol

Structure:



Nomenclature:
17a-methyl-5a-androst-1-ene-3b,17b-diol, or
17α-methyl-5α-androst-1-ene-3β,17β-diol
Sometimes labelled as methyl-1-etiocholenolol-epietiocholanolone

Current Clones (Brand Names):
Celtic Labs Celtic One, Anabolic Technologies Xtreme MASS, IronFlex Supplements: Alpha-90, LGI Alpha 20

Anabolic/Androgenic Ratio:
420:82-100 vs. methyltestosterone by oral administration.

History:
Methyl-1-Androstenediol is a synthetic compound first synthesized by researchers at Searle in 1961. It was originally sold as a supplement by Legal Gear as "Methyl-1-Alpha" in 2005.

Structure and Function:
Methyl-1-Androstenediol is a prohormone to methyl-1-testosterone, via the enzyme 3bHSD.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, strength
Typically dosed at: 40-60mg for four weeks

Links:
CEL Alpha One & Methyl-1-Alpha (M1A) Bible - TunedSports.com

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Dimethazine

Structure:



Nomenclature:
2a,17a-dimethyl-5a-androstan-17b-ol-3,3′-azine, or
2a,17a-dimethyl-5a-androstan-17b-ol-3-one-azine

Synonyms:
Dimethazine, dymethazine, Roxilon, mebolazine

Current Clones:
Anabolic Technologies Xtreme DMZ, LGI DMZ-15

Anabolic:Androgenic Ratio:
210:95-97 compared to methyltestosterone by oral administration.

History:
The synthesis of dimethazine was first reported by the Research Laboratories of Ormonoterapia Richter in Milan, Italy in 1962. It was released as a supplement by iForce Nutrition as "Dymethazine" in 2008.

Structure and Function:
Dimethazine is a homodimer: a chemical compound made from two identical subunits, joined together by a bond. In this case, two units of methasterone (superdrol) joined by a covalent nitrogen-nitrogen bond. The ketazine is expected to hydrolyze in the stomach to yield methasterone and hydrazine. Dimethazine's anabolic activity is believed to result from these methasterone metabolites.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking
Typically dosed at: 30-60mg for four to six weeks

More information:
Dimethazine - Total Flex Blog

Links:
The Dymethazine & Dzine Bible - TunedSports.com
Forgotten steroid dymethazine turns up in designer supplement - Ergo-Log.com
Dimethazine profile - Primordial Performance
17b-hydroxy-2a,17b-dimethyl-5a-androstan-3-one-azine (Dymethazine): What is it?

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M1,4ADD

Structure:



Nomenclature:
17a-methyl-androst-1,4-diene-3,17b-diol

Synonyms:
Methyl-1,4-androstadiene-diol

Anabolic:Androgenic Ratio:
Unknown

History:
M1,4ADD was first sold as a supplement by Designer Supplements in 2004.

Structure and Function:
M1,4ADD is a diol prohormone to the oral steroid dianabol (via the enzyme 3bHSD). As a 1,4-diene it's not subject to reduction of the delta-4 double bond to a 5a-H configuration (instead preferentially reduced to inactive 5b-H metabolites).

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? Yes.
Does it aromatize? It is expected to aromatize.
Typically used for: Bulking, strength
Typically dosed at: 90-120mg for four weeks

Links:
M1,4ADD (Dianabol Precursor) Guide & Review - TunedSports.com
M1,4ADD profile - Primordial Performance
17a-methyl-1,4-androstadiene-3,17diol (M1,4ADD): What is it?

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Methylandrostanol

Structure:



Nomenclature:
17a-methyl-17b-hydroxy-5a-androstane

Discontinued Clones (Brand Names):
Protodrol, Protomax

Current Clones (Brand Names):
Celtic Labs Protobol

Anabolic:Androgenic Ratio:
183:100 compared to methyltestosterone by oral administration (as measured by Organon in 1961).
280:46-58 compared to methyltestosterone by oral administration (as measured by Searle in 1966).

History:
Methylandrostanol was first synthesized by researchers at Organon in the Netherlands in 1961. The cholestatic effect of this and other steroids in rabbits was assayed by Harry Lennon at GD Searle & Co. in 1966, and methylandrostanol was the only 17a-methyl compound not to increase BSP retention (a marker of hepatotoxicity). Patrick Arnold made some for non-commercial purposes in 2005, and in 2009 it was first released as a supplement as "Protodrol" by iForce Nutrition.

Structure and Function:
Methylandrostanol differs from mestanolone (methyl DHT) by the lack of a 3-ketone (carbonyl function), once thought to be necessary for anabolic or androgenic activity. In vitro experiments performed in 1972 with rabbit liver suggested that the body may be capable of metabolically oxygenating methylandrostanol, meaning that it may function to some extent as a pro-drug to mestanolone.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Lean bulking, cutting, and recomp
Typically dosed at: 50-100mg/day for four to six weeks

Links:
The Protodrol Bible - TunedSports.com
17a-methyl-5a-androst-17b-ol (Protomax): What is it?