does DNP resensitize receptors? - Professional Muscle
I assume you're talking about the androgen receptor?
Guys have been saying for years that "DNP will clean out your receptor sites." I'm not sure if Author L. Rea is the one who jumped the gun with this or if he was merely repeated it, but in Chemical Muscle Enhancement (pg 149), he says "Note of interest: DNP also appears to clean out androgenic receptor-sites and may have caused receptor-site up-regulation!"
Now why would Rea say that DNP "appears" to clean out androgenic receptor-sites? I'd put my money on the effects you see soon after a DNP cycle ends. There's a surge in strength, endurance, and pumps. However, I don't think this has anything to do with the androgen receptor. I've never seen anyone cite evidence supporting that. Even Rea, the king of false information and defective reasoning, speaks of it as speculation, that DNP "may" cause up-regulation.
I spent a few hours researching this specific topic and couldn't find anything deirectly relevant. The best I could find was a study that looked at the effect of DNP on androgen receptors in the prostate. The study found that "In the presence of 2,4-dinitrophenol, the androgen receptor is rapidly deactivated (half life, 2min). The inactive receptor can be reactivated efficiently by an energy-dependent process, even in the absence of protein synthesis." In other words, DNP down-regulates the androgen receptor, at least in the short-term, in the prostate. The receptor can be efficiently reactivated when energy supply is restored.
And that's what you'd expect. DNP stresses cellular energy production, so it's a potent activator of AMPK (the "tank-is-low" signal). AMPK, in turn, serves to activate processes that produce energy (including fat burning) and deactivate processes that consume energy (including protein synthesis). For example, we know that mTOR (an important signaling enzyme for protein synthesis) is a downstream target of AMPK that DNP inhibits. I wouldn't be surprised if DNP down-regulates the androgen receptor as well.
DNP produces some nice effects shortly after going off cycle, but as far as I can tell there's zero evidence that it has anything to do with the androgen receptor. In contrast, we have good, alternative explanations that are actually supported by research, including glycogen supercompensation and increased mitochondrial density.
As for running DNP in the middle of your AAS cycle to "spark new muscle growth once you come off the DNP," it's definitely possible. For example, glycogen supercompensation alone can be very anabolic. If nothing else, you have the benefit of burning some fat while under the protection of strong androgens. I don't think anyone knows if DNP can "spark new muscle growth," but you can certainly give it a try and see what your hunch is.
Hope that helps,
Conciliator