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  1. #21
    Super Moderator Feedback Score 2 (100%) h2s's Avatar
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    Promestanolone

    Chemical Name(s):
    17a-methyl etioallocholan 17b-ol 3-hydroxyimine

    Chemical Formula:
    C20H33NO2

    Molecular Weight:
    319.5

    CAS:
    NA

    Q Qatio:
    2.4

    Anabolic #:
    380/24

    Androgenic #:
    158/20

    Oral Bioavailability:
    Estimated at 40%

    AR Binding Affinity:
    NA

    SHBG Binding Affinity:
    High

    Half Life:
    NA

    Legal Status (US):
    Not listed as a controlled substance

    Average Dose:
    75-100mg/day standalone
    50-75mg/day when stacking

    Average Cycle Length:
    4-6 weeks

    Characteristics

    Promestanolone is a 17aa pro-steroid which converts to the illegal anabolic steroid methyl-DHT (mestanolone).

    There is no human clinical data on promestanolone, but it is most likely exerting its effects by converting to methyl-DHT. The acidic environment in the stomach would be responsible for converting the 3-hydroxyimine group to a 3-one — thus rapidly changing it to methyl DHT. Therefore results and side-effects would be considered to be very similar to methyl-DHT.

    Although DHT can be deactivated in skeletal muscle tissue by 3b-HSD it is likely that this enzyme pathway can be overwhelmed if this compound is taken at a high enough dose. Methyl-DHT has some activity on the progestin receptor, but not to a high degree. It has moderate anabolic but high androgenic effects. It binds strongly to SHBG, therefore free testosterone and estrogen can be expected to rise by displacement from SHBG.

    Since this is a 17aa compound, liver toxicity will be an issue with high doses or long term use. For this reason users should consider priming the liver with a liver supporting supplement before and during a Promestanolone cycle. Users will also experience minimal subcutaneous water retention since there is no conversion to estrogen. However, intracellular water and sodium retention will increase by inhibition of 11-beta hydroxylase and mineralocorticoid build up.

    Users may also experience an increase in aggression and mood swings which is a common side effect of many steroids with high androgenic value. This makes this compound an excellent pre-lifting or pre-competition steroid.

    Promestanolone should produce solid lean gains in muscle as a standalone. However for those looking to add additional bulk to their cycle, promestanolone would stack with with virtually any other non-17aa oral.

    Common Clones:

    D-Plex by Competetive Edge Labs (CEL)
    The ONE by Applied Nutraceuticals

    References

    “Effect of 1-alkyl substitution on the biological action in a series of androstanes.”

    Cekan Z, Pelc B.
    Steroids. 1966 Aug;8(2):209-18.

    “Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin.”
    Saartok T, Dahlberg E, Gustafsson JA.
    Endocrinology. 1984 Jun;114(6):2100-6.

  2. #22
    Super Moderator Feedback Score 2 (100%) h2s's Avatar
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    Dienedione (Tren)

    Chemical Name(s):
    19-norandrosta-4,9-diene-3b,17b-dione
    estra-4,9-diene-3b,17b-dione
    4,9 Estra

    Chemical Formula:
    C18H22O2

    Molecular Weight:
    270

    CAS:
    NA

    Q Qatio:
    NA

    Anabolic #:
    NA

    Androgenic #:
    NA

    Oral Bioavailability:
    Estimated at 20%

    AR Binding Affinity:
    5

    [B]SHBG Binding Affinity: [/B
    ]NA

    Half Life:
    NA

    Legal Status (US):
    Listed as a controlled substance

    Average Dose:
    100-200mg/day standalone
    50-100mg/day when stacking

    Average Cycle Length:
    4-6 weeks

    Ratings (On Scale of -5 to +5):

    Muscle Gain: +3
    Strength Gain: +3
    Fat Gain (Negative Indicates Fat loss): -1
    Water Retention: +2
    Aggression: +3
    Libido: -2
    Acne: 0
    Hair Loss: +1
    Prostate Enlargement: +2
    Liver Toxicity: +1
    Lethargy 0

    Characteristics

    Dienedione is a non-methylated steroid that converts to a steroid known as 17b-hydroxy-estra-4,9,(10)-dien-3-one (dienolone).

    Although dienedione may have some anabolic activity on its own, it gets most of its effects from conversion to dienedrone by interaction with 17b-HSD. This steroids overall effects are somewhere between trenbolone and nandrolone.

    Dienedione is known for causing night sweats via its powerful thermogenic effects similar to trenbolone. This thermogenic effect makes dienedione an excellent choice for dropping bodyfat during cutting cycles.

    As a 19-nor this compound has decent progestational effects which may lead to gyno symptoms, libido loss and aggressive mood swings. Part of the reason gyno may be a problem with this compound is also because it lacks androgenic potency and down-regulates DHT levels during cycle, which is the body’s natural estrogen blocker.

    Dienedione does not convert to estrogen, although it can still lead to the side-effects mentioned above. Because this compound is not 17aa liver toxicity is not really a concern. However some users have reported elevated liver enzyme values during cycle, although this could be related to other factors.

    Users usually experience rapid gains in strength and aggression, followed by significant weight gain after several weeks. The results are generally fairly lean with only minor bloat due to the progestational effects.

    Dienedione can be used as a standalone. In an effort to prevent libido loss and gyno, it may be stacked with testosterone or one of its non-aromatizing metabolites to help keep DHT levels elevated during cycle.

    Common Clones:


    Dienedrone by Advanced Muscle Science (AMS)
    Liquidrone UTT by Advanced Muscle Science (AMS)
    X-Tren by Competitive Edge Labs (CEL)
    Tren Xtreme by American Cellular Labs
    Tren 250 by Genetic Edge Technologies (GET)
    Trena by Nutracoastal

    References

    Anabolic Pharmacology
    Seth Roberts (2009)

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