I dont get sore joints always unlike some folks who really suffer from joints on low E2, usualy its more like stiffnes. I dont get morning wood, and my erections are not best. sometimes I get symptoms like dull headache, even cold feet (in winter time), and even flu like symptoms, and fatigue as well. On high end is much worse and E2 interferes with thyroid so on top of high E2 symptoms sometimes I get thyroid symptoms (panick attacks). Also interesting is that E2 affects smell under the armpits- when it goes high its different and harder to control. I found estrogen really hard to control, as sometimes is ok for a while, sometimes goes bit up, and sometimes goes up too much- and so far I cant predict it.