Scope's TRT Journey.......

[Jelisej]

Aren't hormone particles already measured in the microns anyway? Also Jel, is there any advantage to transdermal preg vs pills?

There are some advantages, like better absorption and somewhat slower release, lot of guys do bit better on topical - but there are not many transdermals/creams on market and they are all expensive as well. And usually oral works fine.





Very interesting post by Raymond Peat, MA, PhD (Univ. of Oregon)(tough I think its not entirely correct):
"Pregnenolone is largely converted into two other "youth-associated" protective hormones, progesterone and DHEA. At the age of 30, both men and women produce roughly 30 to 50 mg. of pregnenolone daily. When taken orally, even in the powdered form, it is absorbed fairly well. One dose of approximately 300 mg (the size of an aspirin tablet) keeps acting for about a week, as absorption continues along the intestine, and as it is "recycled" in the body. Part of this long lasting effect is because it improves the body's ability to produce its own pregnenolone. It tends to improve function of the thyroid and other glands, and this "normalizing" effect on the other glands helps to account for its wide range of beneficial effects."

[Scope75]

Pregnenolone is ordered.

Applied 4 pumps of dermecrine all over my chest, shoulders, and traps yesterday morning.

Should I apply 1 pump to the balls?

[weekend]

Yes but not every day cause eventually I get rashy

[Spank]

Amazon.com: Life Extension Pregnenolone 100 Mg Capsule, 100-Count: Health & Personal Care

This is even cheaper than the other link you posted, free shipping with prime also or if you buy 2 you get free shipping.

That's a really interesting read, Jelisej

Any insight as to what you think is incorrect or maybe overstated?

[Scope75]

That link was just for reference and this is what I bought.
High Strength Pregnenolone 50 mg 50 mg 180 Capsules 4012 | Pregnenolone | Piping Rock Health Products

Your link is 100mg caps and Jel said to take 50mg so that wouldn't work for me either.

- - - Updated - - -

Yes but not every day cause eventually I get rashy

I'll just hold off them.
Don't like itchy balls.

[weekend]

Did you get blood results yet?

[Scope75]

It's only been 1.5 days since they drained me if 10 vials of blood so it'll be next week before anyone would even know and my next appointment is 2/9 so 10-11 days to go.

Started all my supps back up along with 4 pumps of dermacrine to hold me over until then. I'll start pregnenolone as soon as it arrives.

[weekend]

what a coincidence. i have an appointment on 2/9

[Jelisej]

Pregnenolone is ordered.
Applied 4 pumps of dermecrine all over my chest, shoulders, and traps yesterday morning.
Should I apply 1 pump to the balls?

No need to apply DHEA/Preg to testicles as in reality conversion difference with DHEA/Preg is insignificant, with testosterone gel is a big difference
in any case testosterone will be increased soon, so should DHT as well- if unhappy with DHT levels that will be addressed separately.

In any case target here is pregnenolone itself+DHEA adn other adrenal hormones which than has cascading effect on whole endocrine system and more than that.
These days lot of endocrinologists do not test pregenolone (or its metabolites) when starting people on TRT for one reason- its always low.

[Jelisej]

That's a really interesting read, Jelisej
Any insight as to what you think is incorrect or maybe overstated?

Taking 300 mg once weekly simply does not work well in practice as it would create spike in preg and other stuff, probably lot of would convert to progesterone which is not always good idea.

Also not sure if it "improves the body's ability to produce its own pregnenolone", tough sometimes eople who supplemented with it after some time need less of it to maintan decent levels.