SHBG questions

[Haritec]

Others will explain this better than me - but when they say irreversible in this regard they do not mean for life. The exemestane binds to aromatase irreversibly - in that it does not let go and the aromatase is disabled from converting anything to estrogen. But it only does it for one molecule for each molecule of exemestane. It is also called a suicidal inhibitor (as I recall ) in that it destroys itself by binding to aromatase.

Your body continues to make aromatase and if you don't take any fresh exemestane - that new aromatase wont be bound to exemestane so will be active just like normal. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 +/- 14% was observed at 12 h. So after about 24 hours most of the effect is gone.

Pharmacokinetics and dose finding of a potent aromatase inhibitor, ... - PubMed - NCBI