Bottle dosage was 250mg per tab take 4 times a day no more than 6 pills a day warning so went total 1500 mg each day for a week then 2000mg per day for a week then down to 1000mg per day right up and through blood test. No bad sides besides a little acid burbs at 2000mg per day but that week noticed best results kicking in and felt much better. Not a youngster so liver probably done a lot of work in the past. Might needed some extra help getting cleaned out.