Most researched SERM is clomid as it is prescribed off-label as part of fertility and HRT regimens now. As with any drug, there are benefits and risks. With clomid, the biggest risk is LH insensitivity if too high of a dose is utilized for too long and the emotional sides that some get while using the drug. Toremifene appears to be the safest of the group, but good luck finding legitimate toremifene right now as it is quite scarce at the moment. I personally hate nolva and will not touch the stuff anymore.