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  1. #1
    Super Moderator Feedback Score 2 (100%) h2s's Avatar
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    HCG - Unraveled: HCG Guide by Eric Potratz

    HCG - Unraveled
    By Eric M. Potratz (©Eric Potratz, All Rights Reserved, Reprinted with Permission)


    Eric M. Potratz has developed his education in the field of endocrinology and performance enhancement through years of research, counseling, and real world experience. Over the past five years he has been a private consultant for hundreds of athletes and bodybuilders alike, and is the founder & president of Primordial Performance.



    Post-Cycle-Therapy is a must upon cessation of steroid use. Many great Post Cycle Therapy protocols have been outlined over the years, and many individuals have had success with following such protocols. Nevertheless, what works can always work better, and I intend to show you the most effective way to recover from AAS. This is especially the case for those that have had a lack of success following popular advice. In this article I will address the misunderstanding and misuse of Human Chorionic Gonadotropin (hCG) and show you the most efficient way to use hCG for the fastest and most complete recovery.


    hCG unraveled -

    Human Chorionic Gonadotropin (hCG) is a peptide hormone that mimics the action of luteinizing hormone (LH). LH is the hormone that stimulates the testes to increase testosterone levels. (1) More specifically LH is the primary signal sent from the pituitary to the testes, which stimulates the leydig cells within the testes to produce testosterone.


    When steroids are administered, LH levels rapidly decline. The absence of an LH signal from the pituitary causes the testes to stop producing testosterone, which causes rapid onset of testicular degeneration. The testicular degeneration begins with a reduction of leydig cell volume, and is then followed by rapid reductions in intra-testicular testosterone (ITT), peroxisomes, and Insulin-like factor 3 (INSL3) - All important bio-markers and factors for proper testicular function and testosterone production. (2-6,19) However, this degeneration can be prevented by a small maintenance dose of hCG ran throughout the cycle. Unfortunately, most steroid users have been engrained to believe that hCG should be used after a cycle, during Post-Cycle-Therapy. Upon reviewing the science and basic endocrinology you will see that a faster and more complete recovery is possible if hCG is ran during a cycle.



    First, we must understand the clinical history of hCG to understand its purpose and its most efficient application. Many popular “steroid profiles” advocate using hCG at a dose of 2500-5000iu once or twice a week. These were the kind of dosages used in the historical (1960's) hCG studies for hypogonadal men who had reduced testicular sensitivity due to prolonged LH deficiency. (21,22) A prolonged LH deficiency causes the testes to desensitize, requiring a higher hCG dose for ample stimulation. In men with normal LH levels and normal testicular sensitivity, the maximum increase of testosterone is seen from a dose of only 250iu, with minimal increases obtained from 500iu or even 5000iu. (2,11) (It appears the testes maximum secretion of testosterone is about 140% above their normal capacity.) (12-18) If you have allowed your testes to desensitize over the length of a typical steroid cycle, (8-16 weeks) then you would require a higher dose to elicit a response in an attempt to restore normal testicular size and function - but there is cost to this, and a high probability that you won't regain full testicular function.

    One term that is critical to understand is testosterone secretion capacity which is synonymous to testicular sensitivity. This is the amount of testosterone your testes can produce from any given level of LH or hCG stimulation. Therefore, if you have reduced testosterone secretion capacity (reduced testicular sensitivity), it will take more LH or hCG stimulation to produce the same result as if you had normal testosterone secretion capacity. If you reduce your testosterone secretion capacity too much, then no amount of LH or hCG stimulation will trigger natural testosterone production - and this leads to permanently reduced testosterone production. (recovering full testosterone production is a topic for another article)



    To get an idea of how quickly you can reduce your testosterone secretion capacity from your average steroid cycle, consider this: LH levels are rapidly decreased by the 2nd day of steroid administration. (2,9,10) By shutting down the LH signal and allowing the testis to be non-functional over a 12-16 week period, leydig cell volume decreases 90%, ITT decreases 94%, INSL3 decreases 95%, while the capacity to secrete testosterone decreases as much as 98%. (2-6)

    Note: visually analyzing testes size is a poor method of judging your actual testicular function, since testicular size is not directly related to the ability to secrete testosterone. (4) This is because the leydig cells, which are the primary sites of testosterone secretion, only make up about 10% of the total testicular volume. Therefore, when the testes may only appear 5-10% smaller, the testes ability to secrete testosterone upon LH or hCG stimulation can actually be significantly reduced to 98% of their normal production. (3-5) So do not judge how "shutdown" you are by testicular size!




    The decreased testosterone secretion capacity caused by steroid use was well demonstrated in a study on power athletes who used steroids for 16 weeks, and were then administered 4500iu hCG post cycle. It was found that the steroid users were about 20 times less responsive to hCG, when compared to normal men who did not use steroids. (8) In other words, their testosterone secretion capacity was dramatically reduced because they did not receive an LH signal for 16 weeks. The testes essentially became desensitized and crippled. Case studies with steroid using patients show that aggressive long-term treatment with hCG at dosages as high as 10,000iu E3D for 12 weeks were unable to return full testicular size. (7) Another study with men using low dose steroids for 6 weeks showed unsuccessful return of Insulin-like factor-3 (INSL3) concentration in the testes upon 5000iu/wk of HCG treatment for 12 weeks (6) (INSL3 is an important biomarker for testosterone production potential and sperm production) 20



    In light of the above evidence, it becomes obvious that we must take preventative measures to avoid this testicular degeneration. We must protect our testicular sensitivity. Besides, with hCG being so readily available, and such a painless shot, it makes you wonder why anyone wouldn't use it on cycle.


    Based on studies with normal men using steroids, 100iu HCG administered everyday was enough to preserve full testicular function and ITT levels, without causing desensitization typically associated with higher doses of hCG. (2) It is important that low-dose hCG is started before testicular sensitivity is reduced, which appears to rapidly manifest within the first 2-3 weeks of steroid use. Also, it's important to discontinue the hCG before you start Post-Cycle-Therapy so your leydig cells are given a chance to re-sensitize to your body's own LH production. (To help further enhance testicular sensitivity, the dietary supplement Toco-8 may be used)


    Based off the above information, an optimal dose of hCG during the cycle would be 250iu every 4 days, or as a less desirable alternative, once a week shot of 500iu. Keep in mind, that the half-life of hCG is 3-4 days, while the half-life of LH is only 1-2 hours. Considering this difference in excretion time, it is best to space each dose of hCG at least 4 days apart for the optimal "peak and valley" replication. However, going more than 7 days between each hCG shot may promote increase the rate of desensitization from lack of LH or hCG stimulation.

    If you are starting hCG late in the cycle, one could calculate a rough estimate for their required hCG "kick starting" dosage by multiplying 40iu x days of LH absence. (ie. 40iu x 60 days = 2400iu HCG dose)


    Remember, since the testes will be desensitized later in a cycle, you will require a higher dose. Also, the maximum daily dose of hCG should not exceed 5000iu, and 4-7 days must be taken off between each shot. Generally, a higher dose will require a longer off period between each shot. (eg., 2500iu = 7 days between each shot)

    Note: If following the on cycle hCG protocol, hCG should NOT be used for PCT.



    Recap -

    For preservation of testicular sensitivity, use 250iu every 4 day starting 14 days after your first AAS dose. At the end of the cycle, drop the hCG two weeks before the AAS clear the system. For example, you would drop hCG about the same time as your last Testosterone Enanthate shot. Or, if you are ending the cycle with orals, you would drop the hCG about 10 days before your last oral dose. This will allow for a sudden and even clearance in hormone levels. This will initiate a strong LH and FSH surge from the pituitary, to begin stimulating your testes to produce testosterone. Remember, recovery doesn't begin until you are off hCG since your body will not release its own LH until the hCG has cleared the system.


    In conclusion, we have learned that utilizing hCG during a steroid cycle will significantly prevent testicular degeneration. This helps create a seamless transition from “on cycle” to “off cycle” thus avoiding the post cycle crash.



    References -

    1. Glycoprotein hormones: structure and function.

    Pierce JG, Parsons TF 1981
    Annu Rev Biochem 50:466-495

    2. Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression

    Andrea D. Coviello, et al
    J. Clin. Endocrinol. Metab., May 2005; 90: 2595 - 2602.

    3. Luteinizing hormone on Leydig cell structure and function.

    Mendis-Handagama SM
    Histol Histopathol 12:869-882 (1997)

    4. Leydig cell peroxisomes and sterol carrier protein-2 in luteinizing hormone-deprived rats

    SM Mendis-Handagama, et al.
    Endocrinology, Dec 1992; 131: 2839.

    5. Effect of long term deprivation of luteinizing hormone on Leydig cell volume, Leydig cell number, and steroidogenic capacity of the rat testis.

    Keeney DS, et al.
    Endocrinology 1988; 123:2906-2915.

    6.The Effects of Gonadotropin Suppression and Selective Replacement on Insulin-Like Factor 3 Secretion in Normal Adult Men

    Katrine Bay, et al
    J. Clin. Endocrinol. Metab., Mar 2006; 91: 1108 - 1111.

    7. Successful treatment of anabolic steroid-induced azoospermia with human

    chorionic gonadotropin and human menopausal gonadotropin
    Dev Kumar Menon, et al.
    FERTILITY AND STERILITY VOL. 79, SUPPL. 3, JUNE 2003

    8. Testicular responsiveness to human chorionic godadotrophin during transient hypogonadotrophic hypogonadism induced by androgenic/anabolic steroids in power athletes

    Hannu et al.
    J. Steroid Biochem. Vol. 25, No. 1 pp. 109-112 (1986)

    9. Comparison of testosterone, dihydrotestosterone, luteinizing hormone, and follicle-stimulating hormone in serum after injection of testosterone enanthate of testosterone cypionate.

    Schulte-Beerbuhl M, et al 1980
    Fertil Steril 33:201-203

    10. Effects of chronic testosterone administration in normal men: safety and efficacy of high dosage testosterone and parallel dose-dependent suppression of luteinizing hormone, follicle-stimulating hormone, and sperm production.

    Matsumoto AM, et al 1990
    J Clin Endocrinol Metab 70:282-287

    11. Effect of human chorionic gonadotropin on plasma steroid levels in young and old men.

    Longcope C et al
    Steroids 21:583-590 (1973)

    12. Regulation of peptide hormone receptors and gonadal steroidogenesis.

    Catt KJ, et al
    Rec Prog Horm Res 1980; 36:557-622

    13. Effect of human chorionic gonadotropin on the endocrine function of Papio testes

    GV Katsiia, et al
    Probl Endokrinol (Mosk), Sep 1984; 30(5): 68-71.

    14. Reproductive function in young fathers and grandfathers.

    Nieschlag E, et al.
    J Clin Endocrinol Metab 55:676-681 (1982)

    15. The aging Leydig cell III Gonadotropin stimulation in men.

    Nankin HR, et al. 1981
    J Androl 2:181-189

    16. Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin.

    Harman SM, et al. 1980
    J Clin Endocrinol Metab 51:35-40

    17. Prolonged biphasic response of plasma testosterone to single intramuscular injections of human chorionic gonadotropin.

    Padron RS, et al. 1980
    J Clin Endocrinol Metab 50:1100-1104

    18. Gonadotrophins and plasma testosterone in senescence. In: James VHT, Serio M, Martini L, eds. The endocrine function of the human testis.

    Mazzi C, et al. 1974
    New York: Academic Press, Inc.; 51-66

    19. Androgen biosynthesis in Leydig cells after testicular desensitization by luteinizing hormone-releasing hormone and human chorionic gonadotropin.

    Dufau ML, et al.
    Endocrinology 105 1314-1321 (1979)

    20. Insulin-Like Factor 3 Serum Levels in 135 Normal Men and 85 Men with Testicular Disorders: Relationship to the Luteinizing Hormone-Testosterone Axis

    K. Bay, S. et al
    J. Clin. Endocrinol. Metab., Jun 2005; 90: 3410 - 3418.

    21. Stimulation of sperm production by human chorionic gonadotropin after prolonged gonadotropin suppression in normal men.

    Matsumoto AM, et al 1985
    J Androl 6:137-143

    22. Human chorionic gonadotropin and testicular function: stimulation of testosterone, testosterone precursors, and sperm production despite high estradiol levels.

    Matsumoto AM, et al. 1983
    J Clin Endocrinol Metab 56:720-728

  2. #2
    SwoleSource Member Feedback Score 0 therealest77's Avatar
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    HCG - Unraveled: HCG Guide by Eric Potratz

    The innovator...brilliant mind this guy.

  3. #3
    A 1k Club Member Feedback Score 0
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    If starting late, after 1 "kickstarting" dose, resume with normal dosing protocol?

  4. #4
    Super Moderator Feedback Score 2 (100%) h2s's Avatar
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    Quote Originally Posted by longBallLima View Post
    If starting late, after 1 "kickstarting" dose, resume with normal dosing protocol?
    That is my understanding. I never asked, as I just start it from the begining.

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    A 1k Club Member Feedback Score 0
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    Quote Originally Posted by h2s View Post
    That is my understanding. I never asked, as I just start it from the begining.
    Got it. thanks! I gotta make a decision since my hcg is taking a good while

  6. #6
    Established Member Feedback Score 0 Bucks's Avatar
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    HCG - Unraveled: HCG Guide by Eric Potratz

    I shot 500 twice a week for the last 4 weeks of a 12 week cycle . Worked good for me.

  7. #7
    A 1k Club Member Feedback Score 0 Jelisej's Avatar
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    My understanding is that HCG should be used from day one, for 3 reasons- 1. It is better to prevent any testicular shrinkage which most likely will happen at second week (although it will not be visible)
    2. HCG should keep testosterone up (for example after first injection of test e natural production will be reduced/stopped and in first week or two, before test e kicks in there will be drop on tt levels, using HCG will prevent this, other option is using some other gear for "kick start" cycle- but even in that case HCG must be used as testicular shrinkage will be fast as well
    3. HCG has positive effect on other hormones as well, and also it stimulates thyroid- and if thyroid works faster than higher testosterone levels can be reached

    HCG should not be used as part of PCT, I've seen people using clomid and HCG together but this is big mistake and HPTA will not start working until HCG clears off.

  8. #8
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    Jel, I have to agree with everything you say. You are totally on the money.

  9. #9
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    So some sources state HCG only necessary for cycles over, say, 6-8 weeks. thoughts on this?

  10. #10
    A 1k Club Member Feedback Score 0 Jelisej's Avatar
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    Quote Originally Posted by pman42 View Post
    So some sources state HCG only necessary for cycles over, say, 6-8 weeks. thoughts on this?
    Well, there are options where you dont need HCG, but I would not consider them as a "cycle"- for example when trying to "top up" your endocrine system- for example when adding DHEA or pregnenolone in which case there will not be supression until it starts "overfilling"- theoretically with correct dosage it can be taken indefinitely (though its hard to find right dosage).

    From anecdotal evidences- turinabol has a minimal effect on other hormones so HCG is not necessary for most of turinabol cycles (turinabol has other sides though).

    For typicall cycles IMO HCG should be used- for real gains high hormonal levels should be reached, and in that case suppression and testicular shrinkage will happen. Personaly- I dont see point in cycles where people stop at point when "things just started to happen", if you know what I mean- anyone who wants to do cycle has to be fully commited to it, with "gameplan" ready.

    And also must be said that testicular atrophy cant be determined by size of testicles as Leydig cell represent only small % of testicles size- so person can be fully atrophied without changes in size of testicles and it can happen in under two weeks. And testicular atrophy is the longest part of recovery in PCT- so its much better to prevent it.
    Last edited by Jelisej; 12-26-2012 at 06:26 AM.

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