Allopreg is a positive modulator of GABA-A so allopreg (and THDOC) are not modulating GABA as they should be, i.e. in reference to stress, anxiety, sleep etc.
The depleted neurosteroids is the source (from low 5AR I in the CNS), the GABA absence is just further down the chain.
Funny you brought up, Mirtazapine (remeron) is probably one of the last few things on my last that I haven't tried yet, it is pretty expensive. It does elevate neurosteroids pretty well and lowers adrenalin and pro thyroid, check out the links below. It is probably the only anti depressant "type" drug that I would consider trying (Peat considers it useful in certain situations, which I was surprised about) it has some similar benefits to androsterone (R-andro), but again I'm not condoning its use just like to show the research. Another member on Peat said they recovered using it.
https://raypeatforum.com/community/t...-others.15646/
https://raypeatforum.com/community/t...enaline.12425/
https://raypeatforum.com/community/t...ortisol.15626/
https://raypeatforum.com/community/t...chanism.16991/