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  1. #31
    Established Member Feedback Score 0 JoeP26's Avatar
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    Quote Originally Posted by Mojo View Post
    Is applying andro a bandaid fix or will it change the way receptors function in the longterm?
    Any kind of exogenous hormone use will change epigenetic expression. Androsterone should change the expression in the long run for the better. But not EpiAndrosterone.

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    Quote Originally Posted by Turnover25 View Post
    Thanks for the well thought out response man. I appreciate it
    Sure thing!

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    Quote Originally Posted by Mojo View Post
    Could you in a way counteract the epi with big doses of theanine to partially activate the glutamate instead?
    No

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    Quote Originally Posted by Brooks View Post
    I oddly respond better to the blend of Epi and Andro (Ultra Hard) rather than just pure Andro.

    I somewhat enjoy the stimulating effect Epi has, whereas I just donít feel pure Andro as much. I think others have responded better to the blend as well. Maybe thereís some genetic variance here?
    Depends on how upregulated the individual's GABAA receptors are.

  2. #32
    SwoleSource Member Feedback Score 0
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    Quote Originally Posted by JoeP26 View Post
    Any kind of exogenous hormone use will change epigenetic expression. Androsterone should change the expression in the long run for the better. But not EpiAndrosterone.
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    Question about this statement. Using UltraHard (Epi and Andro) would still downregulate AR receptors correct? Just not help with the GABAA receptors as much as just Androsterone alone would?

  3. #33
    Established Member Feedback Score 0 JoeP26's Avatar
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    Quote Originally Posted by Karlucchi View Post
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    Question about this statement. Using UltraHard (Epi and Andro) would still downregulate AR receptors correct? Just not help with the GABAA receptors as much as just Androsterone alone would?
    It will but it will also upregulate GABAA receptors and this may make problems worse for some who are neurosteroid deficient in the brain and already have severely upregulated GABAA receptors. Androsterone solo products would prevent that and actually help downregulate GABAA, which you'd typically want in PFS.

  4. #34
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    Quote Originally Posted by JoeP26 View Post
    It will but it will also upregulate GABAA receptors and this may make problems worse for some who are neurosteroid deficient in the brain and already have severely upregulated GABAA receptors. Androsterone solo products would prevent that and actually help downregulate GABAA, which you'd typically want in PFS.
    Great info, man

  5. #35
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    Now I just need someone to tell me how to get my hands on some andro in the EU

  6. #36
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    Looking for some andro products available in the EU I came across this:

    https://www.predatornutrition.com/pr...o+Testosterone)

    Blend:
    Androsterone (150mg)
    1 androstene-3b-ol,17-one (50mg)
    4 androstene-3b-ol,17-one (50mg)
    Arimistane (50mg)

    I'm doubtful about the Arimistane (which is an aromatase inhibitor)

    Thoughts?

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