I could be wrong but another hypothesis I have on the head pressure / hole in my head feeling I have might actually be from the stupid spinal tap they did to me on my second emergency room visit...

my memory isn't perfect on whether I had it before but pretty sure I didn't have it until AFTER the spinal tap but I just attributed everything to the ru58841

the doctors here were so terrible they didn't even mention the warnings of the procedure (it can actually be quite dangerous) nor did they say report your doctor if you have a headache and to rest horizontally for a while... when 25% of young men will have a headache from it. also even for people with MS they usually wait it out before doing the procedure.