I tried it two times to certify that Lions Mane was causing it, i thinked about the chance of the herb of last day could be causing it, but wasn't, the both time i took Lions mane, on the same day, my depression did rise of level, suicidal thoughts, great sadness, brain fog and so on... and it did last for days, i had to exclude sadly....but, this is the only herb wich cause me it.....