First of all, hi to all guys i'm new here but it's been a long time i've reading your discussions and i found this site interesting.
English is not my native language, so i'm sorry if i made mistakes here and there trying to write things right.
About me: graduate in Physics, specializing in Cosmology but stopped due to problems in my life. I'm 34 years old. Long story of depression that it's almost disappeared now thanks to TRT. However i worked for Bayer for almost a year (in 2005) in studying long term effects of Mesterolone (Proviron here in Italy) (i was one of his lab rats, and i contributed to the study and conclusions on Proviron.) Here's the original study (not the one i've participated, because was never officially published. This one was long-term although the one i've participated was much longer):
[Effects of long-term use of mesterolone on different urine metabolites in andrological patients (author's transl)]. - PubMed - NCBI
I'm sorry for the short introduction and lack of english, but i keep thing short because Xanax over my 15 year abuse has ruined my brain and memory, only beginning to recover now thanks to my doctor that finally decided to put me on TRT seeing how much Mesterolone has improved my life (seeing low T lab results don't do much here in Italy, doctors see Testosterone as evil here....no more words on this).
However, seeing this forum as a good place for information, i must point out some mistakes that i want to share just because i don't want disinformation to ruin someone's life.
I decided to write here after seeing the debate that's going on; apart from the shame it caused in the last pages, i see you guys are very helpful in sharing your Prohormone runs and results for everyone who suffer from some form of depression (i've never used Finasteride or Dutasteride or any 5 AR blocker in my life, but being a depressive-bipolar-adhd sufferer as a child, i want to share my little contrbution). Hope it helps. I see CDnuts and Tubzy as very pleasant and informed person, but....Tubzy there's one BIG thing i have to disagree with as can be very dangerous to someone trying to cure himself. Androsterone has GABA agonism, very potent but not to the extent of other neurosteroids (3a,17a Androstanediol is more potent, although less androgenic; the most potent in human body however is Allopregnanolone, 5 alpha reduced-3a hydroxy dehidrogenated Progesterone). It's not the same for Epiandrosterone, quite the opposite: Epi is the stereoisomer that actually has agonism to the GABA C receptor BUT it's a NEGATIVE allosteric modulator, act on GABA A receptor as an ANTAGONIST (so diminishing benzodiazepine-like effects) stimulates the NMDA receptor, (similarly to DHEA and almost every stereoisomer) resulting in an excitatory neurosteroid (similarly to DHEA) that can augment anxiety diminishing chloride-channel signaling; and it can be even dangerous to our hearts (in high amounts and for prolonged period of use) blocking Calcium Ca2+ channels. Every 3b neurosterid share that similar characteristics, that's why our bodies have much higher amounts of 3a reduced steroids (when all function properly). Sorry i would not be seen as rude or prig, especially because i know in forums everyone who has low post count is seen as "noob" (correct??). However sorry to everyone i have problem with english and in communicating (even if i'm behind a monitor) but i am used to work and live alone, only with numbers and formulas and i don't know how to act with people. However i can try to do my best if someone want to communicate with me. Don't get bothered if i don't respond or write even for days, i can only write when i feel i can. Hope i can help. Bye everyone.