Testosterone Discussion

[BoneDaddy]

Dose-Dependent Effects of Testosterone on Regional Adipose Tissue Distribution in Healthy Young Men

Linda J. Woodhouse, Nidhi Gupta, Meenakshi Bhasin, Atam B. Singh, Robert Ross, Jeffrey Phillips and Shalender Bhasin
- Author Affiliations


Abstract

Testosterone supplementation reduces total body adipose tissue (AT), but we do not know whether the effects are uniformly distributed throughout the body or are region specific, or whether they are dose related.

We determined the effects of graded doses of testosterone on regional AT distribution in 54 healthy men (18–35 yr) in a 20-wk, randomized, double-blind study of combined treatment with GnRH agonist plus one of five doses (25, 50, 125, 300, or 600 mg/wk) of testosterone enanthate (TE). Total body, appendicular, and trunk AT and lean body mass were measured by dual-energy x-ray absorptiometry, and sc, intermuscular, and intraabdominal AT of the thigh and abdomen were measured by magnetic resonance imaging. Treatment regimens resulted in serum nadir testosterone concentrations ranging from subphysiological to supraphysiological levels. Dose-dependent changes in AT mass were negatively correlated with TE dose at all sites and were equally distributed between the trunk and appendices. The lowest dose was associated with gains in sc, intermuscular, and intraabdominal AT, with the greatest percent increase occurring in the sc stores. At the three highest TE doses, thigh intermuscular AT volume was significantly reduced, with a greater percent loss in intermuscular than sc depots, whereas intraabdominal AT stores remained unchanged. In conclusion, changes in testosterone concentrations in young men are associated with dose-dependent and region-specific changes in AT and lean body mass in the appendices and trunk. Lowering testosterone concentrations below baseline increases sc and deep AT stores in the appendices and abdomen, with a greater percent increase in sc depots. Conversely, elevating testosterone concentrations above baseline induces a greater loss of AT from the smaller, deeper intermuscular stores of the thigh.

Full Article: Dose-Dependent Effects of Testosterone on Regional Adipose Tissue Distribution in Healthy Young Men

Hmmmm, makes me want to jump immediately to a Test cycle instead of waiting until I get leaner......damnit

Moved to appropriate section -h2s

[burlyman30]

The full article, though lengthy, is pretty informative. They in effect shut off the ability of the guys' bodies to circulate their own testosterone through a procedure, and then used all different doses. Only the 300 and 600mg groups got significant benefits all the way around. The 125mg group had just a slight benefit.