Quote Originally Posted by JoeP26 View Post
I can already tell you why it works. The underlying issue is methylation on thousands of genes in DNA. We just had a study released this week that was 8 years in the making. They examined 26 different PFS guys and took penile tissue samples. In the samples, they surveyed a plethora of genes and found over 3,000 had been methylated. Methylation on genes causes either overexpression or underexpression of various enzymes, receptors, and chemicals. In short, a shitload of things got altered. I'll link to it below.

Differential Gene Expression in Post-Finasteride Syndrome Patients

The protocol calls for long water fasts, which puts your body into ketosis. That's when the adrenals pump out an excess amount of ketones from caloric deficits, which are endogenous butyrates that act as HDAC inhibitors and they demethylate genes when in circulation. So, water fasting is actually reversing all of this methylation slowly overtime. Thing is, you don't need to water fast to get these in your system. They have butyrates OTC, like sodium butyrate, BHB, and Tributyrin, that you can take daily. Additionally, you then use certain things in the protocol that stimulate hormones and neurotransmitters, which also help to influence gene expression, while not water fasting. Eventually, the switches are flipped, gene expression is restored, and you feel better again.

Sadly, if you have primary hypogonadism and are on TRT, you have a very rough road ahead in recovery. I never recommend standalone TRT for PFS. There is absolutely no way to fix testes that have been damaged due to steroid usage. The testes are responsible for producing most of the testosterone that circulates through body. But they also produce a modest amount of progesterone. When you use TRT, you obviously suppress the testes and are only supplementing the androgens but not the progestogens. If you absolutely have to use TRT because your testes are permanently damaged, then you would need to use a small amount of progesterone with the TRT to get Allopregnanolone downstream. Something like 10-25mg of progesterone cream once daily before bed.

If your testes aren't permanently damaged, then you need to get off of it and get your LH and FSH back up, which will also get progesterone back up. Typically, doctors will give you clomid for that and some HCG to wake the boys up after being suppressed for so long.
Aren't all the overexpressed and underexpressed genes simply that way because of the faulty androgen receptor though, and don't function as well because of weak androgen signaling.

If we could fix the AR straight away, wouldn't that in large solve the problem.