Originally Posted by
JoeP26
Perhaps. But the problem in PFS of low IGF-1 and GH is the GABAA positive modulating neurosteroids in the brain, like Androsterone and Allopregnanolone. They stimulate GAD (short for Glutamic Acid Decarboxylase) which is a reducing agent that converts Glutamate (an excitatory neurotransmitter) into GABA (a sedative neurotransmitter). GABA was found in a study to potently stimulate GH secretion from the pituitary when administered to a control group. On average, it raised GH levels by ~400%. And we know in PFS that individuals have low to undetectable levels of Allopregnanolone in CSF. This in turn would cause low GABA levels as well then low GH and low IGF-1, since GH stimulates IGF-1 production in the liver. This pattern is actually used by some doctors in treating PFS nowadays. And even generalized TBI.
I should also add that several in this forum and the WhatsApp group had neurotransmitters tested, including myself, through ZRT. All of us had severely low GABA.
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