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  1. #1
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    Quote Originally Posted by Cdsnuts View Post
    This is a bit of a stretch. If you were MORE sensitive to hormones you would have less issues. If anything, you're less sensitive to hormones in pfs.
    I think it's more complicated than people give think. If it was just a case of making people more sensitive to androgens, then doing steroid cycles would cure people, since following steroid use, androgen receptors are upregulated, however it's true that if anything, people are worse after a steroid cycle.

    With GABA receptors, it's obvious, however, that the lack of allopreganolone is the reason for upregulated GABA receptors i.e. the body is searching for more GABA agonists/ modulators to go back into homeostasis, which of course there aren't. That's also why pretty much everyone recovers their mental sides, albeit temporarily, while on 5a-DHP.

    I also wanted to know your advice on Zuranolone actually @Cdsnuts. It's designed to replicate allopregnanolone, and if it's released, could prove extremely beneficial as an addition to the regimen.

  2. #2
    Moderator Feedback Score 0 Cdsnuts's Avatar
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    Quote Originally Posted by MungYarlon View Post
    I think it's more complicated than people give think. If it was just a case of making people more sensitive to androgens, then doing steroid cycles would cure people, since following steroid use, androgen receptors are upregulated, however it's true that if anything, people are worse after a steroid cycle.

    With GABA receptors, it's obvious, however, that the lack of allopreganolone is the reason for upregulated GABA receptors i.e. the body is searching for more GABA agonists/ modulators to go back into homeostasis, which of course there aren't. That's also why pretty much everyone recovers their mental sides, albeit temporarily, while on 5a-DHP.

    I also wanted to know your advice on Zuranolone actually @Cdsnuts. It's designed to replicate allopregnanolone, and if it's released, could prove extremely beneficial as an addition to the regimen.
    Of course it is....but at the same time, the reason for it is not.

    I was simply stating that you are less sensitive to hormones while in a pfs state, regardless of mechanism. I agree with everything else you're saying.

    It could be.....but then again it would depend on the way it's designed. Because it's a pharmaceutical, unfortunately it will always come with a price to pay. Pharmaceuticals are really, really good at making the body incapable of working without them once they sink their hooks in. I most likely would not recommend it during the protocol.
    Total Male Optimization "People who say it can't be done shouldn't interrupt those that are doing it"

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