I think it's more complicated than people give think. If it was just a case of making people more sensitive to androgens, then doing steroid cycles would cure people, since following steroid use, androgen receptors are upregulated, however it's true that if anything, people are worse after a steroid cycle.
With GABA receptors, it's obvious, however, that the lack of allopreganolone is the reason for upregulated GABA receptors i.e. the body is searching for more GABA agonists/ modulators to go back into homeostasis, which of course there aren't. That's also why pretty much everyone recovers their mental sides, albeit temporarily, while on 5a-DHP.
I also wanted to know your advice on Zuranolone actually @
Cdsnuts. It's designed to replicate allopregnanolone, and if it's released, could prove extremely beneficial as an addition to the regimen.