USP Vera-1

[Macdon1588]

Just got this in, the primary ingredient is aegeline which I researched. It appears that it reduces fertility (boo). Can you more science based guys google it and tell me you're thoughts?

[Scope75]

I Don't follow these supps so what's this one suppose to do??

[Rulk]

Just got this in, the primary ingredient is aegeline which I researched. It appears that it reduces fertility (boo). Can you more science based guys google it and tell me you're thoughts?

Shit that's scary.

I Don't follow these supps so what's this one suppose to do??

Same thing that the last one ( Compound 20 ) did. A almost cureall for the everyday lifter. It'll do anything that you are trying to accomplish- getting leaner while maintaining muscles, getting stronger and leaner while getting bigger..

I like usp labs supps, they do work, but they over-exaggerate ( go figure ) immensly the benefits of their products. They get everyone hyped up on their inner circle releases and "Beta Testing". It seems like every logger trys to outdo the other testimonials and past inner circle releases. A very much placebo effect taking place. The marketing is genius though and they are making cheddar like no other.

Oh, and I have fallen for the hype before too and become part of the machine as well. Some stuff I would like to have if I was sponsored, no doubt, but for the money and results- steroids are where it's at.

[Cobalt]

It's VERSA-1, btw.

I have a couple bottles on the way.
I used to be big with USP Labs team before I found PP... funny that someone with USP pointed me toward PP in the first place.

Any how, they do hype up their products, but some to deliver. The best stuff that I've used that isn't hormonal came from USP. They are way too pricey, so it's a toss up on what you want.

I do swear by Jack3d (micro) and PowerFULL, fantastic stuff.

It'll be a while before I use the Versa-1, but I'll weigh in my 2 cents when I do get around to it.

EDIT:

The nutritional info states that the compound is:
N-[2-Hydroxy-2(4-Methoxyphenyl) Ethyl]-3-Phenyl-2-propenamide, Cytidine 5’-diphoscholine, or aegeline as stated above.
(USPLabs Versa-1 (30 Capsules): Discount Versa-1 Supplements)

I'm curious what study you found that said it reduced fertility?

[machdaddy]

^^^ I have the inner circle release right now. Like cobalt it won't be used for a while but most of USP stuff works. Just not like 30 days = 30 lbs of lean muscle.

[Rulk]

Lemme me know how it goes guys, I am sure you will give it a fair and unbiased review. As a fan of usp labs, I do want to try it, i'll admit that.

[Macdon1588]

It's VERSA-1, btw.

I have a couple bottles on the way.
I used to be big with USP Labs team before I found PP... funny that someone with USP pointed me toward PP in the first place.

Any how, they do hype up their products, but some to deliver. The best stuff that I've used that isn't hormonal came from USP. They are way too pricey, so it's a toss up on what you want.

I do swear by Jack3d (micro) and PowerFULL, fantastic stuff.

It'll be a while before I use the Versa-1, but I'll weigh in my 2 cents when I do get around to it.

EDIT:

The nutritional info states that the compound is:
N-[2-Hydroxy-2(4-Methoxyphenyl) Ethyl]-3-Phenyl-2-propenamide, Cytidine 5’-diphoscholine, or aegeline as stated above.
(USPLabs Versa-1 (30 Capsules): Discount Versa-1 Supplements)

I'm curious what study you found that said it reduced fertility?

I looked up the compound and it is also known as aegeline. It was just your standard google search and it was it was your typical rat study stuff. I could be way wrong and would love to be so if you can do so.

[Scope75]

Shit that's scary.

Same thing that the last one ( Compound 20 ) did. A almost cureall for the everyday lifter. It'll do anything that you are trying to accomplish- getting leaner while maintaining muscles, getting stronger and leaner while getting bigger..

I like usp labs supps, they do work, but they over-exaggerate ( go figure ) immensly the benefits of their products. They get everyone hyped up on their inner circle releases and "Beta Testing". It seems like every logger trys to outdo the other testimonials and past inner circle releases. A very much placebo effect taking place. The marketing is genius though and they are making cheddar like no other.

Oh, and I have fallen for the hype before too and become part of the machine as well. Some stuff I would like to have if I was sponsored, no doubt, but for the money and results- steroids are where it's at.

Yeah that's what I figured.
There products do work but just not like they claim, and most probably comes from people training harder becaus they are taking a super supp from the lost hills of MARS. LOL

[Rulk]

Found this:

High Tower Pharmacology: New "Anabolic:" Aegeline

Pharmacology
In the murine model of diabetes, aegeline was shown to decrease blood sugar at a dose of 100 mg/kg. Converting this to HED based on BSA equals about 840 mg for a 70 kg adult human. At a human equivalent dose of about 420 mg, aegeline was demonstrated to decrease triglycerides, while improving cholesterol ratios in the murine model of dyslipdemia (1). The authors concluded, "The reasonable mapping of [aegeline] to validated pharmacophoric hypothesis and 3D QSAR model with an estimated activity (283 nM) suggest that [aegeline] might be a beta(3)-AR agonist." A follow-up study done in 2011 by the same researchers confirmed aegelines antihyperlipidemic & antihyperglycemic properties (2).

These results should not be surprising as octopamine has been known for years to possess these properties (3). In fact, octopamines beta(3)-agonism was clearly elucidated as far back as 1999 (4). Unfortunately, the beta(3)-adrenergic receptor is only weakly contributatory to lipolysis in humans, and octopamine was demonstrated to possess no capacity to induce lipolysis at all (4, 5). In beta(3) insensitive animals (humans), octopamine actually induces pro-adipogenic cascades through its production of hydrogen peroxide via intracellular deamination (3).


Summary
Aegeline may indeed possess inherent anabolism as a function of its ability to convert into an octopamine derivative. Indeed, para-methoxy-octopamine (Para-OMe-Octopamine) is one of octopamines metabolites via COMT in humans. Unfortunately, the anabolism that aegeline induces is likely restricted to adipocytes since humans are extremely insensitive to beta(3)-AR agonism.

In the studies in which aegeline demonstrated antihyperglycemic and antihyperlipidemic properties, the animals utilized were both murine which, as described above, are beta(3)-AR receptor sensitive. Furthermore, these animals were tested against specific disease pathologies to amplify their effects. It should go without saying that the results produced will probably not translate to humans.


References
(1) Antihyperglycemic and antidyslipidemic ... [Bioorg Med Chem Lett. 2007] - PubMed - NCBI
(2) Synthesis of novel N-(2-hydroxy-2-p-tol... [Bioorg Med Chem Lett. 2011] - PubMed - NCBI
(3) http://jpet.aspetjournals.org/content/299/1/96.long
(4) Selective activation of β3-adrenoceptors by octopamine: comparative studies in mammalian fat cells - Springer
(5) No functional atypical beta-adrenergic receptors in... [Life Sci. 1994] - PubMed - NCBI

Found more:

High Tower Pharmacology

Methoxyoctopamine: Structure & Activity

p-Methoxyoctopamine (Para-Methoxy-Octopamine, P-OMe-Octopamine) is an interesting compound formed after en vivo hydrolysis of various natural amides such as Aegeline and Tembamide.





Structure Activity Relationships (SAR)
According to the marketing advertisements related to both compounds, these compounds are purported to be potent beta-agonists, and therefore suitable for inducing fat loss, as well as promoting "focus," and endowing "CNS stimulation." There is no evidence for any of these claims, although there is decades of SAR research which would contradict these statements.




Beta-Agonism

As has been discussed in many previous articles, methylating the para position removes beta-1 and beta-2 adrenergic affinity. This is one of the ways the body "deactivates" catecholamines with the enzyme Catechol-O-Methyl-Transferase (COMT). Since methoxyoctopamine already possesses a para-methoxy substituent, it is already deactivated. Conversely, a para-methoxy substituent does not remove beta-3 agonism. In mice and other animals, this property may confer significant fat loss potential. Unfortunately, as I mentioned in the previous article, beta-3 agonism does not promote significant fat loss in humans.




CNS Stimulation

P-OMe-Octopamine also possesses a hydroxy (-OH) subsituent on the beta carbon. This substituent effectively eliminates significant CNS penetration, and therefore would remove "CNS stimulation" as a potential effect of the drug. Conversely, the para-methoxy substituent actually promotes BBB penetration, and therefore would allow CNS penetration in the absence of the beta-OH. Unfortunately, the effects of CNS penetration would only be negative (i.e. dysphoria) and so the lack of CNS penetration is probably a good thing (See Para-methoxyamphetamine).




Releasing

Since methoxyoctopamine is a primary phenylethylamine, it may still retain properties related to catecholamine releasement (See the Pharmacology of 1,3-DMAA). This effect may allow a transient dumping of synaptic norepinephrine which may manifest as symptoms of the adrenergic cascade (tachycardia, tachypnea, hypertension). In contrast to 1,3-DMAA which probably has significant BBB penetration, methoxyoctopamine would not produce the "positives" of catecholamine releasement such as true CNS stimulation, and focus. The effects produced by methoxyoctopamine would probably be similar to those produced by N-methyltyramine, albeit relatively weaker due to the para-methoxy substituent.


Summary
Para-Methoxy-Octopamine formed after en vivo hydrolysis of Aegeline and Tembamide.
The para-methoxy substituent removes beta-1 and beta-2 adrenergic receptor affinity, although still allowing for the possibility of beta-3 receptor affinity.
No ability to induce lipolysis (fat loss) in humans
The beta-OH removes substantial CNS penetration.
No ability to produce CNS stimulation.
May still retain catecholamine releasing potential, allowing for transient peripheral stimulation.
Much better alternatives exist.

[ctAL]

interesting................


i will be keeping and eye on this.