Vitamin D Discussion

[Avl]

50k a day? no doubt its a waste..as for my 15k or so, at about 10-15 bucks a bottle im ok with that.

[Alex]

Vitamin D is an important element for our body. I like this discussion and i found lot of useful stuff about it. I am completely agreed with the above post that its a complete wastage of money.

[Right Hook]

50k a day? no doubt its a waste..as for my 15k or so, at about 10-15 bucks a bottle im ok with that.

Refer to post #36

[Jelisej]

I did not know that aromatase inhibitors can significantly reduce vitamin D levels:
Effect of baseline serum vitamin D l... [Breast Cancer Res Treat. 2012] - PubMed - NCBI
From study: Absolute serum levels of vitamin D increased significantly at one year in the anastrozole group (2.88 ng/ml, [1.71, 4.06; P < 0.0001]) but not in the placebo group (0.75 ng/ml [-0.35, 1.85; P = 0.18]).

From exemestane/aromasin label:
--WARNINGS AND PRECAUTIONS------------------------
•
Reductions in bone mineral density (BMD) over time are seen with
exemestane use
(5.3).
•
Routine assessment of 25-hydroxy vitamin D levels prior to the start of
aromatase inhibitor treatment should be performed (5

Another study (on women) who were treated with letrozole and supplemented with vitamin D
Effect of vitamin D supplementation ... [Breast Cancer Res Treat. 2010] - PubMed - NCBI
From study:
After 16 weeks of letrozole, more women with 25OHD levels >66 ng/ml (median level) reported no disability from joint pain than did women with levels <66 ng/ml (52 vs. 19%; P = 0.026). Vitamin D deficiency and insufficiency are prevalent in post-menopausal women initiating adjuvant AI. Vitamin D3 supplementation with 50,000 IU per week is safe, significantly increases 25OHD levels, and may reduce disability from AI-induced arthralgias.