The Most Independently reviewed and blood tested Testosterone Booster

[burlyman30]

Here is the link:
Linus Pauling Institute at Oregon State University



Meaning when estrogen is present it lowers estrogen and when there is an absence it can act as estrogen.

Thank you, O.N.

[O.N.]

Supporting links, please.

D-Aspartic Acid and the secret to Italian Loving

The brain consists of D-Aspartate being converted into a very prominent signaling metabolite called NMDA (N-methyl-D-Aspartate). This influx of NMDA in the anterior pituitary and hypothalamus causes an acute secretion of Growth Hormone Releasing Hormone (GHRH), Prolactin releasing factors (PRFs), and Gonadotropin Releasing Hormone (GnRH). These hormones then induce production and secretion of Growth Hormone (GH), Prolactin, and both Follicle Stimulating hormone (FSH) and Luteinizing hormone (LH). (Another nice source)

It’s basically an anabolic cascade.

It also suppresses dopamine release (temporarily), so it’s not all perfect (and with the secretion of Prolactin, not too good of a combo for a prolonged period of time).

Finally, it seems to induce release of both Melatonin-stimulating factor and GABA (a relaxing neurotransmitter) in the hypothalamus, suggesting that D-Aspartic acid would be better taken in the PM.

also more detailed info here all are from human trials: D-Aspartic Acid - In-Depth Scientific Supplement Information | Examine.com just search for key words in the text like prolactin melatonin etc

[burlyman30]

D-Aspartic Acid and the secret to Italian Loving

The brain consists of D-Aspartate being converted into a very prominent signaling metabolite called NMDA (N-methyl-D-Aspartate). This influx of NMDA in the anterior pituitary and hypothalamus causes an acute secretion of Growth Hormone Releasing Hormone (GHRH), Prolactin releasing factors (PRFs), and Gonadotropin Releasing Hormone (GnRH). These hormones then induce production and secretion of Growth Hormone (GH), Prolactin, and both Follicle Stimulating hormone (FSH) and Luteinizing hormone (LH). (Another nice source)

It’s basically an anabolic cascade.

It also suppresses dopamine release (temporarily), so it’s not all perfect (and with the secretion of Prolactin, not too good of a combo for a prolonged period of time).

Finally, it seems to induce release of both Melatonin-stimulating factor and GABA (a relaxing neurotransmitter) in the hypothalamus, suggesting that D-Aspartic acid would be better taken in the PM.

also more detailed info here all are from human trials: D-Aspartic Acid - In-Depth Scientific Supplement Information | Examine.com just search for key words in the text like prolactin melatonin etc

"Shown to upregulate aromatase enzyme in boar and lizard testes" is all it says. And this would happen if testosterone levels rose.

[O.N.]

"Shown to upregulate aromatase enzyme in boar and lizard testes" is all it says. And this would happen if testosterone levels rose.

Yeah agreed if test goes up so will estrogen conversion however the words up regulate aromatase enzyme do not sound great. The tests would need to be of greater detail showing the testosterone:estrogen ratio (T:E) to see if supplementing with DAA alone alters this ratio or if simply put both raise equally.

I do not think that has been studied as of yet.

[O.N.]

Involvement of D-Asp in P450 aromatase activity ... [Amino Acids. 2007] - PubMed - NCBI

Endocrine roles of D-aspartic acid in the testi... [J Endocrinol. 2005] - PubMed - NCBI

http://www.reproduction-online.org/c...5/803.full.pdf
from the above PDF:

The physiological mechanism underlying the inverse and direct relationships between D-Asp and, testosterone and oestradiol, respectively, were evident from the results of the experiments in vitro. The results showed that when D-Asp is added to an incubation medium containing testosterone and either homogenate or acetone powder extracts of ovarian follicles, a significant increase in aromatase activity occurs, which converts testosterone to oestradiol. Aromatase was characterized using linear Michaelis–Menten plots. Furthermore, the aromatase activity was four times greater in the presence of D-Asp than in its absence; however, the nearly equivalent values of the two K m values (both approximately 25 nmol l –1 ) indicate that aromatase has the
same catalytic properties in both cases

[markam]

I think AI makes you wise user you can fight prolactine continuously or just one time a day or once every second day aromatization of testosterone to estrogen but this doesn't solve the problem of to low estrogen in the bloodstream specifically "good" estrone" involved in joins wellness and some anabolism of muscle tissue. With stopping the aromatisation by ingesting AI (specifically permament AI type steroid based not like in RES 100 WHERE AI IS FLAVONE BASED NON PERMAMENT)YOU CUT NOT ONLY the bad 17 estradiol type of estrogene you also hurt yourself by cutting "good estrone" estrogen . Every action has a reaction, and there are always unintended consequences.

I just wanted to add that manufactures and distributors of AIs bsed on flavons not permamently inhibiting aromatase rarery declare benefits of such inhibitors compare to AI based on steroids (ATD, 6-BROMO arimistane etc.) which could have severe side effects

Thanks, excellent post. Personally I wouldn't feel comfortable using only resveratrol with DAA especially if the DAA was doubled dosed. I was considering maybe 50mgs 6-Bromo, but perhaps you have a better suggestion, and maybe a OTC alternative? I've found Triazole to be effective in some circumstances, but whether it would be strong enough in this instance, I don't know.

[O.N.]

Be sure to check out our new website: RES100 Wicked Supplements

[O.N.]

Lots of big things happening this year.....including a clinical trial, stay tuned more info to come in the next few weeks.

[O.N.]

We had a meeting today with the University of NSW in regards to conducting our clinical trial, it looks like it will take a little time to get it underway however all things today were positive and it looks like conducting the trial will not be an issue.

[O.N.]