Prohormone and Designer Steroid Profiles

17a-methyl DHT derivatives:
Methyldiazirinol
Dimethazine
Epistane
Methylstenbolone
Dimethandrostenol
Superdiol
2,17-Dimethandrostenolone
Methyl-1-androstenediol
Methylandrostanol (Protodrol)
Mestanolone-oxime (The One/D-Plex)
Cynostane

17a-methyl 4-enes:
Halodrol
Methyl Clostebol
Promagnon (P-Mag)
M1,4ADD
2,17-dimethandrostenolone (Dimethabold)
Methandrostenolone-oxime (Dianadrol)
Methandrostenolone-hydrazone (Diabolix)

Non-17a-methyls:
11-Ketotestosterone
Mesterolone-oxime (Mestebol)
6-Chlorotestosterone
2-Androstenone
2-Androstenol
Adrenosterone (11-oxo)
Furazadrol
Epiandrosterone
1-Androsterone
4-DHEA

19-nors:
Trestolone
Trendione
MENT-dione
Methoxygonadiene (M-LMG)
Norethandriol
Dienolone
18-Methyl-19-nortestosterone

Please feel free to reproduce this information for non-commercial purposes provided that no significant changes are made, all images are included, and attribution is given to the authors (Brymaster and henryv).

Only compounds currently available as supplements in the US market have been included. No responsibility is taken for the accuracy of this information, which is for entertainment purposes only. External links are there to provide breadth in discussion, and may contain inaccuracies, or opinion presented as fact. Typical uses, doses, and cycle durations are observations, not recommendations.

Halodrol

Structure:
http://www.totalflexblog.com/wp-cont.../halodrol1.png

Nomenclature:
4-chloro-17a methyl-androst-1,4-diene-3,17b-diol

Discontinued Clones (Brand Names):
Halodrol-50, H-drol, Halovar, Hemadrol,

Current Clones (Brand Names):
Helladrol, Halo-Plex, Halostane, Celtic Labs Halo Mass, IronFlex Supplements Halo X

Anabolic/Androgenic Ratio:
Unknown

History:
This compound was originally released into the bodybuilding supplement market by Gaspari Nutrition as “Halodrol-50″. Unlike most compounds, it had not previously been studied by steroid researchers in the pharmaceutical industry. The target hormone, Oral Turinabol, was used both clinically and as part of the East German doping machine.

Structure and Function:
Commercial h-drol clones contain a mixture of 3a- and 3b-hydroxylated stereoisomers. H-drol is taken as a “prohormone” (precursor) to Oral Turinabol. It is transformed into Oral Turinabol by the dehydrogenas enzyme 3bHSD. The 4-chloro modification prevents Halodrol from aromatizing.

Testosterone, DHT, or 19-nortestosterone based? Testosterone based, though it doesn't metabolize to stronger DHT-based metabolites.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking, and recomp
Typically dosed at: 75-100mg for six weeks

More information:
Halodrol - Total Flex Blog

Links:
The Halodrol (H-Drol) Bible - TunedSports.com
Halodrol profile - Primordial Performance
4-chloro-17a-methyl-androst-1,4-diene-3b,17b-diol (Halodrol): What is it?

Methyldiazirinol

Structural Image:
http://www.totalflexblog.com/wp-cont...-structure.jpg

Nomenclature:
3,3-azo-17a-methyl-5a-androstan-17b-ol or
3,3-azo-17α-methyl-5α-androstan-17β-ol

Current Clones (Brand Names):
Iron Legion Triumphalis

Anabolic:Androgenic Ratio:
Methyldiazirinol has an oral anabolic:androgenic ratio of 300:20 (levator ani:ventral prostate) compared to methyl testosterone.

History:
This compound was first synthesized by researchers at Lederle Laboratories in 1965, and though patented, it was not pursued commercially.
In 2013 methyldiazirinol was released onto the dietary supplement market as Iron Legion Triumphalis.

Structure and Function:
Like stanozolol (Winstrol), furazabol, and methylepitiostanol (“Epistane”), methyldiazirinol is a mestanolone (methyl-DHT) derivative that has a heterocyclic ring fused to the A-ring of the steroid. In methyldiazirinol this takes the form of a diazirine moiety at carbon 3.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Cut, recomp, or lean bulk.
Typically dosed at: 45-60mg for 4-6 weeks.

More information:
Methyldiazirinol - Total Flex Blog

Links:
3,3-azo-17a-methyl-5a-androstan-17b-ol (Methyldiazirinol): What is it?

Methyl Stenbolone

Structure:
http://www.totalflexblog.com/wp-cont...ethyl-sten.png

Nomenclature:
2,17α-dimethyl-5α-androsta-1-en-17β-ol-3-one, or
2,17a-Dimethyl-17b-hydroxy-5a-androst-1-en-3-one

Anabolic/Androgenic Ratio:
660:90-170 vs. methyltestosterone by oral administration.

Discontinued Clones (Brand Names):
IDS Mass Tabs
Antaeus Labs Ultradrol

Current Clones (Brand Names):
Antaeus Labs Nanodrol, Anabolic Technologies Xtreme MASS, IronFlex Supplements Ultra-Sten

History:
Methyl stenbolone was first synthesized in 1966, by researchers at Searle Laboratories. It was first listed as an ingredient in a supplement in a product called Mass Tabs by IDS.

Structure and Function:
Methyl stenbolone is a mestanolone (methyl-DHT) derivative with a C1-2 double bond (like M1T) and a C2 methyl group (like superdrol).

Testosterone, DHT, or Nandrolone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking, and recomp
Typically dosed at: 16-30mg for four to six weeks

More information:
Methylstenbolone - Total Flex Blog

Links:
The Methylstenbolone/Ultradrol Guide - TunedSports.com
Methylstenbolone profile - Primordial Performance
2,17a-methyl-5a-androsta-1-en-17b-ol-3-one (Methylstenbolone): What is it?

Trendione

Structure:
http://www.totalflexblog.com/wp-cont.../trendione.png

Nomenclature:
Estra-4,9,11-triene-3,17-dione

Synonyms:
Trendione, RU 2065

Current Clones (Brand Names):
PHF Supplements Trenavar, Celtic Labs Celtitren, Blackstone Labs Super Trenabol

Anabolic/Androgenic Ratio:
Unknown.

History:
Trendione was first synthesized by researchers at Roussel Uclaf in the 1960s, and given the designation RU 2065. It was first sold as a supplement by PHF Supplements as "Trenavar".

Structure and Function:
Trendione is a prohormone to the veterinary steroid trenbolone.

Testosterone, DHT, or 19-nortestosterone based? 19-nortestosterone based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Stacking, lean bulking, and recomp
Typically dosed at: 60-90mg for six weeks

More information:
Trendione - Total Flex Blog

Links:
Pro-hormone version of trenbolone - Ergo-Log.com
Estra-4,9,11-triene-3,17-dione (Trenavar): What is it?

MENT-dione

Structure:
http://www.totalflexblog.com/wp-cont...ment-dione.png

Nomenclature:
7a-methyl-estra-4-en-3,17-dione

Synonyms:
7a-methyl-19-norandrostenedione, MENT dione.

Current Clones (Brand Names):
PHF Supplements Mentabolan

Anabolic/Androgenic Ratio:
960:165-510 compared to testosterone by oral administration.

History:
It was first synthesized and tested for anabolic and androgenic activity in rats by Albert Segaloff in 1963. It was subsequently released as a “prohormone/designer steroid” by PHF/IBE in 2011.

Structure and Function:
Mentdione is a prohormone to the black-market bodybuilding steroid and experimental contraceptive Trestolone, a.k.a. MENT.

Testosterone, DHT, or 19-nortestosterone based? 19-nortestosterone based.
17a-methylated? No. It's 7a-methylated, which doesn't impart the same level of oral toxicity as a 17a-methyl group.
Does it aromatize? It does aromatize.
Typically used for: Stacking, bulking, lean bulking, and recomp
Typically dosed at: 20-30mg for four to six weeks

More information:
Ment-dione - Total Flex Blog

Links:
7a-Methyl-estra-4-en-3,17-dione (Mentabolan, MENT, 7-MENT): What is it?

Dimethandrostenol

Structural Image:
http://www.totalflexblog.com/wp-cont...ndrostenol.jpg

Nomenclature:
2,17α-dimethyl-17β-hydroxy-5α-androst-2-ene or
2,17a-dimethyl-17b-hydroxy-5a-androst-2-ene

Current Clones (Brand Names):
Hard Rock D-drol, Olympus Labs D1methadrol

Discontinued Clones (Brand Names):
Iron Legion Mithras, Iron Legion Nano-Mithras

Anabolic Androgenic Ratio:
1040:320:97 compared to 17a-methyl-testosterone by oral administration.

History:
Dimethandrostenol was first synthesized at the research laboratories of Syntex in Mexico in 1962. In 2013 it was released as a supplement called Mithras by Iron Legion.

Structure and Function:
Dimethandrostenol is a mestanolone (methyl-DHT) derivative with a C2-3 double bond (like pheraplex) and a C2 methyl group (like superdrol and methyl stenbolone).

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking, and recomp
Typically dosed at: 20-30mg for four to six weeks

More information:
Dimethandrostenol - Total Flex Blog

Methoxygonadiene (M-LMG)

Structure:
http://www.totalflexblog.com/wp-cont...ygonadiene.png

Nomenclature:
18-methyl-3-methoxy-estra-2,5(10)-dien-17-one or
13β-ethyl-3-methoxy-gona-2,5(10)-dien-17-one

Synonyms:
Methoxygonadiene, methoxygonadienone, methoxydienone,

Discontinued Clones (Brand Names):
Max-LMG, M-LMG

Current Clones (Brand Names):
IronFlex Supplements Methoxy-25, LGI LMG-25, IronMagLabs Deca-Drol Max, Twisted Iron Supplements Tren M-LMG

Anabolic Androgenic Ratio:
Unknown

History:
This compound first appears in patents dating to the 1960s filed by researchers Gordon Alan Hughes and Herchel Smith at Wyeth Laboratories. Methoxygonadiene is a chemical intermediate in the synthesis of steroids such as Norbolethone and the contraceptives Norgestrel/Levonorgestrel.
In 2005 it was released by ALRI as Max-LMG (LMG stands for “Lean Mass Generator”).

Structure and Function:
Methoxygonadiene is believed to act as a ‘prodrug’ to the biologically active steroid 18-methyl-19-nortestosterone.

Testosterone, DHT, or 19-nortestosterone based? 19-nortestosterone based.
17a-methylated? No.
Does it aromatize? It does aromatize.
Typically used for: Stacking and bulking
Typically dosed at: 75-125mg for six weeks

More information:
Methoxygonadiene - Total Flex Blog

Links:
LMG Guide & Review (Max-LMG) - TunedSports.com
Pro-hormone version of norbolethone is on sale online - Ergo-Log.com
Methoxygonadiene profile - Primordial Performance
13-ethyl-3-methoxy-gona-2,5(10)diene-17-one (Max LMG): What is it?

Norethandriol

Structural Image:
http://www.totalflexblog.com/wp-cont...ethandriol.jpg

Nomenclature:
17α-ethyl-3β,17β-dihydroxy-estr-5-ene or
17a-ethyl-3b,17b-dihydroxy-estr-5-ene

Current Clones (Brand Names):
Iron Legion Legio X

Anabolic/Androgenic Ratio:
400:20 vs methyltestosterone by oral administration.

History:
Norethandriol was first synthesized and its activity assayed by researchers at Syntex in 1958. It was released as a supplement by Iron Legion as "Legio X" in 2013.

Structure and Function:
Norethandriol is expected to act as a prohormone to norethandrolone (Nilevar).

Testosterone, DHT, or 19-nortestosterone based? 19-nortestosterone based.
17a-methylated? No (17a-ethylated).
Does it aromatize? It does aromatize.
Typically used for: Bulking, strength
Typically dosed at: 20-30mg for six weeks

6-Chlorotestosterone

Structure:
http://www.totalflexblog.com/wp-cont...-structure.png

Nomenclature:
6a-chloro-17b-hydroxy-androst-4-en-3-one or
6α-chloro-17β-hydroxy-androst-4-en-3-one

Current Clones (Brand Names):
Shredded Labs Hexadrone, Shredded Labs Hexavar

Anabolic/Androgenic Ratio:
Unknown

History:
6a-chlorotestosterone was first synthesized by researchers at Syntex in 1963. It was first released as a supplement 50 years later, as Hexadrone from Shredded Labs.

Structure and Function:
6a-Chlorotestosterone differs from testosterone only by the substitution of a chlorine atom at carbon 6. This substituent will prevent aromatization, may render it incapable of 5a-reduction, and could make it an aromatase inhibitor.

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Lean bulking, recomp, and cutting
Typically dosed at: 100-250mg for six weeks

Links:
6-chloro-androst-4-ene-3-one-17b-ol (Hexadrone): What is it?

Dienolone

Structure:
http://www.totalflexblog.com/wp-cont.../dienolone.png

Nomenclature:
17β-hydroxyestra-4,9(10)-dien-3-one or
19-norandrosta-4,9(10)-dien-17β-ol-3-one

Current Clones (Brand Names):
Iron Legion Dienazone (topical product)

Anabolic/Androgenic Ratio:
140:43-83 vs methyltestosterone by oral administration.

History:
Dienolone was first synthesized by researchers at Eli Lilly in 1960. It was first sold as a topical product by Antaeus Labs as "Trenazone" in 2010.

Structure and Function:
Dienolone is a nandrolone derivative, differing only by unsaturation (a double bond) at C9-10. This conjugated system increases stability, flexibility, and reduces receptor specificity.

Testosterone, DHT, or 19-nortestosterone based? 19-nortestosterone based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking, strength, and recomp
Typically dosed at: 75-150mg for six weeks (topically)

Links:
Dienolone (Trenazone) Bible - TunedSports.com
Estra-4,9-diene-17b-ol-3-one (Dienolone): What is it?

Promagnon

Structure:
http://www.totalflexblog.com/wp-cont...oads/P-mag.png

Nomenclature:
4-chloro-17α-methyl-androst-4-ene-3,17β-diol, or
4-chloro-17α-methyl-17β-hydroxy-androst-4-en-3-ol

Synonyms:
P-Mag

Current Clones (Brand Names):
Hard Rock Pro-Mag 25

Anabolic/Androgenic Ratio:
Unknown

History:
This compound was first released as "Promagnon 25" from Peak Performance Labs in 2005.

Structure and Function:
P-Mag is a methyltestosterone derivative, differing in that it has a 4-chloro substituent, and a hydroxyl at the 3 position. Promagnon is understood to be a pro-drug to methyl-clostebol (via the 3bHSD enzyme).

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking, and recomp
Typically dosed at: 75-125mg for four to six weeks

Links:
The Promagnon/P-mag Bible - TunedSports.com
4-chloro-17a-methyl-androst-4-ene-3b,17b-diol (Promagnon): What is it?

Methyl Clostebol

Structure:
http://www.totalflexblog.com/wp-cont...lclostebol.png

Nomenclature:
4-chloro-17α-methyl-17β-hydroxy-androst-4-en-3-one, or
4-chloro-17α-methyl-androst-4-en-17β-ol-3-one

Discontinued Clones (Brand Names):
Antaeus Labs Mechabol

Current Clones (Brand Names):
Celtic Labs Celtibol, Androgenetx Mecha Drive, Anabolic Technologies Xtreme H-50, IronFlex Supplements: Mbol-25

Anabolic/Androgenic Ratio:
50:10-15 vs. methyltestosterone by oral administration.

History:
The activity of methyl clostebol was examined by researchers at Sterling Winthrop in the 1960s. There's also some evidence that methyl clostebol was experimented with by the East German doping machine, under the moniker STS 482. Methyl Clostebol was first released as a dietary supplement called Mechabol by Antaeus Labs.

Structure and Function:
Methyl clostebol differs from methyltestosterone by the addition of a 4-chloro atom at C4. This substituent will prevent aromatization, and likely hinders reduction of the delta-4 double bond.

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking, recomp
Typically dosed at: 75-125mg for six weeks

Epistane

Structure:

http://www.totalflexblog.com/wp-cont...-structure.png

Nomenclature:
2a,3a-epithio-17a-methyl-17b-hydroxy-5a-androstane, or
2α,3α-epithio-17α-methyl-17β-hydroxy-5α-androstane

Current Clones (Brand Names):
Celtic Labs Epistane, IronFlex Supplements Brawn, LGI Epi-10

Anabolic/Androgenic Ratio:
1100:91 vs methyltestosterone by oral administration.

History:
Epistane was first synthesized by G.D. Searle & Co in 1966, building on research by Shionogi in Japan. It was first released as a supplement by IBE as "Epistane" and RPN as "Havoc" in 2006.

Structure and Function:
Epistane is a DHT derivative with a heterocyclic episulfide moiety at carbons 2 and 3. It has a 17a methyl function for oral bioavailability.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Lean bulking, cutting, and recomp
Typically dosed at: 20-60mg for four to six weeks

Links:
The Epistane & Havoc Informative Bible - TunedSports.com
Epistane profile - Primordial Performance
2a,3a-epithio-17a-methyl-17b-hydroxy-5a-adrostan (Epistane): What is it?

2-Androstenol

Structure:

http://www.totalflexblog.com/wp-cont...stenol-img.png

Nomenclature:
17b-hydroxy-5a-androst-2-ene, or
5a-androst-2-en-17b-ol

Synonyms:
desoxytestosterone, unmethylated-phera

Current Clones (Brand Names):
PHF Supplements Desoxy T Acetate powder (as acetate ester)

Anabolic/Androgenic Ratio:
Unknown

History
2-androstenol is a naturally occurring compound. It was first synthesized, and its biological activity assayed, by Syntex researchers in 1962. 2-androstenol acetate was first sold as a supplement as a component of Anabolc Xtreme's 3-AD.

Structure and Function:
2-androstenol is a DHT derivative. It is unsaturated (has a double bond) at C2-3. It can be considered the non-17a-methyl analog of desoxymethyltestosterone, or "unmethylated pheraplex".

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Stacking, bulking, lean bulking
Typically dosed at: 50-100mg for four to six weeks

Adrenosterone

Structure:

http://www.totalflexblog.com/wp-cont...id-three-3.png

Nomenclature:
Androst-4-ene-3,11,17-trione

Synonyms:
11-oxo, , 11-oxo-androstenedione, 11-keto-androstenedione, Reichstein's Substance G

Current Clones (Brand Names):
Smart Powders 11-Lean, LGI 11-X, Androgenetx A-Dren 100

Anabolic/Androgenic Ratio:
Unknown

History:
Adrenosterone is a naturally occurring hormone, first isolated in 1936 by Nobel prize-winning Swiss chemist Tadeus Reichstein. It was first sold as a supplement by Patrick Arnold as ErgoPharm "11-oxo".

Structure and Function:
Adrenosterone is a selective inhibitor of the reductase activity of the cortisol-activating enzyme 11β-HSD1. It is also a prohormone to the active androgen 11-ketotestosterone.

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Lean bulking, recomp, cutting
Typically dosed at: 300-1000mg for four to six weeks

Links:
The 11-OXO (Adrenosterone) Bible - TunedSports.com
Androst-4-ene-3,11,17-trione (Adrenosterone): What is it?

Methyl-1-Androstenediol

Structure:

http://www.totalflexblog.com/wp-cont...ds/m1alpha.png

Nomenclature:
17a-methyl-5a-androst-1-ene-3b,17b-diol, or
17α-methyl-5α-androst-1-ene-3β,17β-diol
Sometimes labelled as methyl-1-etiocholenolol-epietiocholanolone

Current Clones (Brand Names):
Celtic Labs Celtic One, Anabolic Technologies Xtreme MASS, IronFlex Supplements: Alpha-90, LGI Alpha 20

Anabolic/Androgenic Ratio:
420:82-100 vs. methyltestosterone by oral administration.

History:
Methyl-1-Androstenediol is a synthetic compound first synthesized by researchers at Searle in 1961. It was originally sold as a supplement by Legal Gear as "Methyl-1-Alpha" in 2005.

Structure and Function:
Methyl-1-Androstenediol is a prohormone to methyl-1-testosterone, via the enzyme 3bHSD.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, strength
Typically dosed at: 40-60mg for four weeks

Links:
CEL Alpha One & Methyl-1-Alpha (M1A) Bible - TunedSports.com

Dimethazine

Structure:

http://www.totalflexblog.com/wp-cont...imethazine.png

Nomenclature:
2a,17a-dimethyl-5a-androstan-17b-ol-3,3′-azine, or
2a,17a-dimethyl-5a-androstan-17b-ol-3-one-azine

Synonyms:
Dimethazine, dymethazine, Roxilon, mebolazine

Current Clones:
Anabolic Technologies Xtreme DMZ, LGI DMZ-15

Anabolic:Androgenic Ratio:
210:95-97 compared to methyltestosterone by oral administration.

History:
The synthesis of dimethazine was first reported by the Research Laboratories of Ormonoterapia Richter in Milan, Italy in 1962. It was released as a supplement by iForce Nutrition as "Dymethazine" in 2008.

Structure and Function:
Dimethazine is a homodimer: a chemical compound made from two identical subunits, joined together by a bond. In this case, two units of methasterone (superdrol) joined by a covalent nitrogen-nitrogen bond. The ketazine is expected to hydrolyze in the stomach to yield methasterone and hydrazine. Dimethazine's anabolic activity is believed to result from these methasterone metabolites.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking
Typically dosed at: 30-60mg for four to six weeks

More information:
Dimethazine - Total Flex Blog

Links:
The Dymethazine & Dzine Bible - TunedSports.com
Forgotten steroid dymethazine turns up in designer supplement - Ergo-Log.com
Dimethazine profile - Primordial Performance
17b-hydroxy-2a,17b-dimethyl-5a-androstan-3-one-azine (Dymethazine): What is it?

M1,4ADD

Structure:

http://www.totalflexblog.com/wp-cont...ads/M14ADD.jpg

Nomenclature:
17a-methyl-androst-1,4-diene-3,17b-diol

Synonyms:
Methyl-1,4-androstadiene-diol

Anabolic:Androgenic Ratio:
Unknown

History:
M1,4ADD was first sold as a supplement by Designer Supplements in 2004.

Structure and Function:
M1,4ADD is a diol prohormone to the oral steroid dianabol (via the enzyme 3bHSD). As a 1,4-diene it's not subject to reduction of the delta-4 double bond to a 5a-H configuration (instead preferentially reduced to inactive 5b-H metabolites).

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? Yes.
Does it aromatize? It is expected to aromatize.
Typically used for: Bulking, strength
Typically dosed at: 90-120mg for four weeks

Links:
M1,4ADD (Dianabol Precursor) Guide & Review - TunedSports.com
M1,4ADD profile - Primordial Performance
17a-methyl-1,4-androstadiene-3,17diol (M1,4ADD): What is it?

Methylandrostanol

Structure:

http://www.totalflexblog.com/wp-cont.../protodrol.jpg

Nomenclature:
17a-methyl-17b-hydroxy-5a-androstane

Discontinued Clones (Brand Names):
Protodrol, Protomax

Current Clones (Brand Names):
Celtic Labs Protobol

Anabolic:Androgenic Ratio:
183:100 compared to methyltestosterone by oral administration (as measured by Organon in 1961).
280:46-58 compared to methyltestosterone by oral administration (as measured by Searle in 1966).

History:
Methylandrostanol was first synthesized by researchers at Organon in the Netherlands in 1961. The cholestatic effect of this and other steroids in rabbits was assayed by Harry Lennon at GD Searle & Co. in 1966, and methylandrostanol was the only 17a-methyl compound not to increase BSP retention (a marker of hepatotoxicity). Patrick Arnold made some for non-commercial purposes in 2005, and in 2009 it was first released as a supplement as "Protodrol" by iForce Nutrition.

Structure and Function:
Methylandrostanol differs from mestanolone (methyl DHT) by the lack of a 3-ketone (carbonyl function), once thought to be necessary for anabolic or androgenic activity. In vitro experiments performed in 1972 with rabbit liver suggested that the body may be capable of metabolically oxygenating methylandrostanol, meaning that it may function to some extent as a pro-drug to mestanolone.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Lean bulking, cutting, and recomp
Typically dosed at: 50-100mg/day for four to six weeks

Links:
The Protodrol Bible - TunedSports.com
17a-methyl-5a-androst-17b-ol (Protomax): What is it?

Methandrostenolone-oxime

Structure:

http://www.totalflexblog.com/wp-cont...dbol-oxime.jpg

Nomenclature:
17a-methyl-17b-hydroxy-1,4-androstadien-3-hydroxyimine

Synonyms:
Methandienone-oxime, Methandrostenolone-oxime, Dianabol-oxime, dbol-oxime

Current Clones (Brand Names):
Celtic Labs Dianadrol, Denadrol

Anabolic:Androgenic Ratio:
Unknown

History:
Methandrostenolone-oxime was released as a supplement by Celtic Labs as "Dianadrol" in 2013.

Structure and Function:
Methandrostenolone-oxime is intended to be a prodrug to the oral steroid dianabol. Ketoximes can be hydrolyzed by acid to ketones.

Testosterone, DHT, or 19-nortestosterone based? Testosterone based, though as a 1,4-diene it's not subject to reduction of the delta-4 double bond to a 5a-H configuration (instead preferentially reduced to inactive 5b-H metabolites).
17a-methylated? Yes.
Does it aromatize? It is expected to aromatize.
Typically used for: Lean bulking, and recomp
Typically dosed at: 45-90mg/day for four to six weeks

Mestanolone-oxime

Structure:

http://www.totalflexblog.com/wp-cont...me-the-one.jpg

Nomenclature:
17a-methyl-5a-androstane-17b-ol-3-hydroxyimine

Synonyms:
The One, D-Plex

Anabolic:Androgenic Ratio:
Unknown

History:
The anabolic and androgenic activities of this synthetic compound (administered parenterally) were first examined at the Research Institute for Natural Drugs in Prague in 1966. It was first released as a bodybuilding supplement by Applied Nutriceuticals as "The One" in 2009.

Structure and Function:
Mestanolone-oxime is generally considered a prodrug to the oral steroid mestanolone (methyl-DHT).

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Lean bulk, cutting, and recomp
Typically dosed at: 75-125mg for four to six weeks

Links:
D-Plex & ‘The One’ Anabolic Cycle Bible - TunedSports.com
New designer steroid The One is really just Methyl-DHT - Ergo-Log.com
Promestanolone profile - Primordial Performance
17-a-methyl-etioallocholan-17b-ol-3-hydroxyimine (D-Plex): What is it?

Cynostane

Structure:

http://www.totalflexblog.com/wp-cont.../cynostane.jpg

Nomenclature:
2-cyano-17a-methyl-17b-hydroxy-androst-3-one

Discontinued Clones (Brand Names):
Cynostane

Current Clones (Brand Names):
Cyanostane

Anabolic:Androgenic Ratio:
Unknown

History:
Cynostane was first released as a supplement by Anabolic Innovations in 2009.

Structure and Function:
Cynostane differs from mestanolone (methyl DHT) by the substitution of a 2-cyano group.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Lean bulking, cutting, recomp
Typically dosed at: 30-40mg for four to six weeks

Links:
Cynostane profile - Primordial Performance
2-cyano-17a-methyl-17b-hydroxy-androst-3-one (Cyanostane): What is it?

Superdiol

Structure:

http://www.totalflexblog.com/wp-cont...superdiol1.jpg

Nomenclature:
2a,17a-dimethyl-5a-androstane-3,17b-diol

Current Clones (Brand Names):
Celtic Mass

Anabolic:Androgenic Ratio:
Unknown

History:
Superdiol was released as a supplement by Celtic Labs as "Celtic Mass" in 2013.

Structure and Function:
Superdiol is intended to function as a prohormone to methasterone (superdrol), via the enzyme 3bHSD.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulking, lean bulking
Typically dosed at: 30-40mg/day for four weeks

Links:
2a,17a-dimethyl-5a-androstane-3,17b-diol (Superdrol precursor): What is it?

Furazadrol

Structure:

http://www.totalflexblog.com/wp-cont...furazadrol.jpg

Nomenclature:
5a-androstano[2,3-c]furazan-17b-tetrahydropyranol ether, or
5a-etioallocholan(2,3-c)furazan-17b-tetrahydropyranol

Synonyms:
Orastan A, Furaza-A, Furaguno

Current Clones:
LGI Furuza-50

Anabolic:Androgenic Ratio:
Unknown

History:
Furazadrol was first released as a supplement by Gaspari Nutrition as "Orastan A" in 2006, though that product and many others since have in fact contained similar isoxazole steroids, not the furazan steroid listed.

Structure and Function:
Furazadrol is a non-17a-methyl analogue of the steroid Furazabol. Furazadrol has instead a tetrahydropyranol ether, intended to improve bioavailability (relative to the plain alcohol) via lymphatic transport.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Recomp and cutting
Typically dosed at: 150-300mg for four to six weeks

Links:
The Orastan/Furazadrol Bible - TunedSports.com
Furazabol THP profile - Primordial Performance
5a-androstanol[2,3]furazan-17b-tetrahydropyranol (Furazadrol): What is it?

2-Androstenone

Structure:

http://www.totalflexblog.com/wp-cont...drostenone.jpg

Nomenclature:
5a-androst-2-en-17-one

Current Clones (Brand Names):
Delta-2

Anabolic:Androgenic Ratio:
Unknown

History:
In 2011 2-androstenone was released roughly simultaneously as AndrogenetX Delta 2 in the US and Fusion Supplements Delta 2 in the UK.

Structure and Function:
This non-methylated compound possesses the Δ2 double bond as found in the designer steroid desoxymethyltestosterone (a.k.a madol, pheraplex), therefore it lacks the 3-keto function common to most anabolic steroids.
2-androstenone is a prohormone to 'unmethylated pheraplex'. It has a 17-keto function, which will be reduced by interaction with the 17bHSD enzyme to the active hormone 2-androstenol (unmethylated phera). This 17b-hydroxylated metabolite is responsible for the anabolic and androgenic effects seen with this drug.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Stacking, bulking, lean bulking
Typically dosed at: 150-600mg for four to six weeks

Links:
New prohormone: Delta-2 - Ergo-log.com
Delta 2-androstenone: What is it?

Epiandrosterone

Structure:

http://www.totalflexblog.com/wp-cont...drosterone.jpg

Nomenclature:
3b-hydroxy-5a-androstan-17-one

Discontinued Clones (Brand Names):
Stanodrol, Androhard,

Current Clones (Brand Names):
Forerunner Labs 5-Alpha Test RDe, IronFlex Supplements Stanozane

Anabolic:Androgenic Ratio:
Unknown

History:
Epiandrosterone is a naturally occurring compound first identified in humans in 1938, though it was first artificially synthesized by Nobel prize-winning Croatian chemist Leopold Ružička in 1934.

Structure and Function:
Epiandrosterone is a naturally occurring metabolite of, and precursor to, dihydrotestosterone (DHT). Epiandrosterone is transformed to DHT by the enzymes 3b-HSD and 17b-HSD.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Stacking, libido, muscle hardness
Typically dosed at: 300-600mg for four to six weeks

More information:
Epiandrosterone Explained, by Brymaster (pdf)

11-Ketotestosterone

Structure:

http://www.totalflexblog.com/wp-cont...stosterone.jpg

Nomenclature:
17β-hydroxy-4-androstene-3,11-dione

Discontinued Clones (Brand Names):
11-Spray, Icon,

Current Clones (Brand Names):
Iron Legion XI-KT (topical)

Anabolic:Androgenic Ratio:
Unknown

History:
11-ketotestosterone was first released as an oral product called Icon by StarChem Labs in 2008. It was subsequently sold as the active ingredient in 11-KT spray, a topical product by Prototype Nutrition, in 2010. In October 2013 Iron Legion released another topical 11-ketotestosterone product called XI-KT.

Structure and Function:
11-ketotestosterone is a naturally-occurring anabolic compound found in trace amounts in humans (it’s a metabolite of adrenal hormones). 11-ketotestosterone is the primary androgen in fish. 11-ketotestosterone is also a strong and selective inhibitor of the cortisol-activating enzyme 11β-HSD1.

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Lean bulking, cutting, and recomp
Typically dosed at: 85-170mg for four to six weeks (transdermally)

More information:
11-Ketotestosterone - Total Flex Blog

1-Androsterone

Structure:

http://www.totalflexblog.com/wp-cont...drosterone.jpg

Nomenclature:
3-hydroxy-5a-androst-1-en-17-one

Synonyms:
1-DHEA

Current Clones (Brand Names):
AMS 1-Andro RDe Chrome, IronMagLabs: 1-ANDRO Rx

Anabolic:Androgenic Ratio:
Unknown

History:
1-DHEA is a naturally occurring hormone. It was first synthesized by Germans Adolf Butenandt and Heinz Dannenberg in 1938. It was first released as a supplement as the third version of Patrick Arnold's "1-AD" product.

Structure and Function:
1-Androsterone is a "two-step" precursor to 1-testosterone. It is transformed to 1-testosterone by the enzymes 3b-HSD and 17b-HSD.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Stacking, lean bulking, cutting, and recomp
Typically dosed at: 300-600mg for four to six weeks

More information:
1-Androsterone Explained, by Brymaster (pdf)

Links:
1-DHEA - Powerful According to Researchers - TunedSports.com
1-Androsterone (1-Testosterone) Guide - TunedSports.com
1-Androsterone profile - Primordial Performance
1-Androstene-3b-ol,17-one (1-Androsterone): What is it?

4-DHEA

Structure:

http://www.totalflexblog.com/wp-cont...ads/4-DHEA.jpg

Nomenclature:
3b-hydroxy-androst-4-en-17-one

Current Clones (Brand Names):
AMS 4-AD UTT, AMS 4-AD RDe Chrome, IronMagLabs 4-ANDRO Rx

Anabolic:Androgenic Ratio:
Unknown

History:
4-dehydroepiandrosterone (4-DHEA) is a naturally occurring compound first artificially synthesized by Croatian chemist Leopold Ružička in 1935.

Structure and Function:
4-DHEA is a two-step prohormone to testosterone (via androstenedione/androstenediol). It undergoes enzymatic biotransformation via 3b-HSD and 17b-HSD.

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? No.
Does it aromatize? It does aromatize.
Typically used for: Stacking, libido, lean bulking, and recomp
Typically dosed at: 400-600mg for four to six weeks

More information:
4-DHEA Explained, by Brymaster (pdf)

Links:
4-DHEA profile - Primordial Performance

Trestolone

Structure:

http://www.totalflexblog.com/wp-cont...trestolone.jpg

Nomenclature:
7a-methyl-17b-hydroxy-estra-4-en-3-one

Synonyms:
MENT

Current Clones (Brand Names):
Celtic Labs Trestobol

Anabolic:Androgenic Ratio:
840:540 compared to methyltestosterone by oral administration.

History:
Trestolone is a synthetic compound first synthesized by J. Babcock and G. Duncan of the Upjohn Company, reported in 1963.

Structure and Function:
Trestolone is a 19-nortestosterone derivative, differing by the addition of a 7a-methyl group. Unlike steroids like testosterone and DHT, trestolone shows no affinity for SHBG, leading to a short half-life. The 7a-methyl group causes steric hindrance to 5a-reduction, and conformational changes that lead to increased androgen receptor affinity.

Testosterone, DHT, or 19-nortestosterone based? 19-nortestosterone based.
17a-methylated? No.
Does it aromatize? It does aromatize.
Typically used for: Stacking, libido, bulking, and lean bulking
Typically dosed at: 20-40mg for four to six weeks

Links:
Triumph for Trestolone: Myelin Regeneration - TunedSports.com
Trestolone Explained, by Mike Arnold

Mesterolone-oxime

Structure:

http://www.totalflexblog.com/wp-cont...lone-oxime.jpg

Nomenclature:
1a-methyl-17b-hydroxy-5a-androstan-3-hydroxyimine

Current Clones (Brand Names):
Celtic Labs Mestebol

Anabolic:Androgenic Ratio:
Unknown

History:
Mesterolone-oxime has no history as a medically-researched drug. The target drug Mesterolone was developed by the German pharmaceutical company Schering in the 1960s, and marketed as "Proviron".

Structure and Function:
Mesterolone-oxime is generally considered a prodrug to the oral steroid mesterolone (proviron). The 3-ketoxime is intended to undergo hydrolysis to the corresponding ketone in the acidic conditions of the stomach. Mesterolone is a DHT-derivative differing from DHT only in the addition of a 1a-methyl group.

Testosterone, DHT, or 19-nortestosterone based? DHT based.
17a-methylated? No.
Does it aromatize? It does not aromatize.
Typically used for: Stacking, libido, lean bulking, recomp
Typically dosed at: 70mg for four to six weeks

18-methyl-19-nortestosterone

Structure:

http://www.totalflexblog.com/wp-cont...stosterone.jpg

Nomenclature:
18-methyl-estr-4-en-3-one-17b-ol, or (more properly)
13β-ethyl-gona-4-en-3-one-17b-ol

Synonyms:
18-methyl-nandrolone, WY3016

Current Clones (Brand Names):
Mostly found as a component of "stacked" products.

Anabolic:Androgenic Ratio:
Unknown. Wyeth described WY3016 as "roughly equipotent" to 19-nortestosterone as an anabolic, and "considerably more androgenic".

History:
18-methyl-19-nortestosterone and other 13-ethylgonanes such as methoxygonadiene, norbolethone, and synthetic contraceptives such as norgestrel were first synthesized and patented by Herschel Smith at Wyeth Laboratories in the 1960s.

Structure and Function:
18-methyl-19-nortestosterone is a nandrolone derivative, differing only in that it has an ethyl group at C13 where nandrolone has a methyl group. It is believed to be the active metabolite of "Max-LMG" (methoxygonadiene).

Testosterone, DHT, or 19-nortestosterone based? 19-nortestosterone based.
17a-methylated? No.
Does it aromatize? It does aromatize.
Typically used for: Bulking
Typically dosed at: Unknown

2,17-dimethandrostenolone

Structure:

http://www.totalflexblog.com/wp-cont...handienone.png

Nomenclature:
2,17a-dimethyl-17b-hydroxy-1,4-androstadien-3-one

Synonyms:
Dimethandrostenolone, Dimethandienone

Current Clones (Brand Names):
Celtic Labs Dimethabold

Anabolic:Androgenic Ratio:
Unknown.

History:
2,17-Dimethandrostenolone was first synthesized by Syntex researchers Fred Kincl and Ralph Dorfman in 1963, though they only assayed its activity by injection. In 2014 it was released by Celtic Labs as "Dimethabold".

Structure and Function:
2,17-Dimethandrostenolone differs from methandrostenolone (dianabol) by the addition of a methyl group at carbon 2. It is likely that this will prevent aromatization of the A-ring, and affect electronic interaction with the target androgen receptor.

Testosterone, DHT, or 19-nortestosterone based? Testosterone based.
17a-methylated? Yes.
Does it aromatize? It does not aromatize.
Typically used for: Bulk, lean bulk, recomp
Typically dosed at: Unknown

Methandrostenazone

Structure:

http://www.totalflexblog.com/wp-cont...-hydrazone.jpg

Nomenclature:
17a-methyl-androst-1,4-diene-17b-ol-3-hydrazone

Synonyms:
Methandienazone, Methandrostenazone

Current Clones (Brand Names):
Iron Flex Diabolix

Anabolic:Androgenic Ratio:
Unknown.

History:
The utility of hydrazone-substituted androgens was investigated by Italian researchers at the Research Laboratories of Ormonoterapia Richter in 1962. They found that the hydrazone and azine derivatives of masteron and superdrol had similar anabolic actions and reduced androgenic effects relative to the parent compounds, leading to an improved anabolic to androgenic ratio in all cases.

Structure and Function:
Methandrostenazone is structurally very similar to methandrostenolone, better known as dianabol. Whereas methandrostenolone has a ketone function at C3, methandrostenazone has a hydrazone moiety at the same position. This hydrazone function should hydrolyze efficiently in vivo to a ketone (i.e. methandrostenazone should convert readily to methandrostenolone).

Testosterone, DHT, or 19-nortestosterone based? Testosterone based (but reduction of the C4-5 double bond proceeds in favour of the 5b-H configuration).
17a-methylated? Yes.
Does it aromatize? It is likely to aromatize.
Typically used for: Bulk, lean bulk, strength
Typically dosed at: Unknown

Quote:

---

Originally Posted by totalflexblog

17a-methyl DHT derivatives:
Methyldiazirinol
Dimethazine
Epistane
Methylstenbolone
Dimethandrostenol
Superdiol
2,17-Dimethandrostenolone
Methyl-1-androstenediol
Methylandrostanol (Protodrol)
Mestanolone-oxime (The One/D-Plex)
Cynostane

17a-methyl 4-enes:
Halodrol
Methyl Clostebol
Promagnon (P-Mag)
M1,4ADD
2,17-dimethandrostenolone (Dimethabold)
Methandrostenolone-oxime (Dianadrol)
Methandrostenolone-hydrazone (Diabolix)

Non-17a-methyls:
11-Ketotestosterone
Mesterolone-oxime (Mestebol)
6-Chlorotestosterone
2-Androstenone
2-Androstenol
Adrenosterone (11-oxo)
Furazadrol
Epiandrosterone
1-Androsterone
4-DHEA

19-nors:
Trestolone
Trendione
MENT-dione
Methoxygonadiene (M-LMG)
Norethandriol
Dienolone
18-Methyl-19-nortestosterone

Please feel free to reproduce this information for non-commercial purposes provided that no significant changes are made, all images are included, and attribution is given to the authors (Brymaster and henryv).

Only compounds currently available as supplements in the US market have been included. No responsibility is taken for the accuracy of this information, which is for entertainment purposes only. External links are there to provide breadth in discussion, and may contain inaccuracies, or opinion presented as fact. Typical uses, doses, and cycle durations are observations, not recommendations.

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2, 17 Dimethandrostenol shouldn't be under DHT derivitives.

You missed Androsterone(3a hydroxy 5a androstane 17 one), Nor-DHEA, are we including Celtics compounds that are being released? M1T-Oxime, and Epitiostanol. Technically Forestane is a PH to 4-Hydroxy Test as well.

As for the oxime compounds, isn't calling the one-oxime incorrect because there is no ketone function. Shouldn't it be like Methandrostenol-hydroxyimine or Methandrostenol-ketoxime.

Oh and I believe the nomenclature was fixed on the 18 methyl Nortestosterone so it is the 13b ethyl is scheduled not the 13a ethyl.

http://www.deadiversion.usdoj.gov/sc...c_cs_alpha.pdf

First page 5th compound listed.