Crashed from rogaine. Can I try TRT?

[Crashed]

But what are the thoughts on going on TRT while I do the CDNut's protocol?

[Cdsnuts]

But what are the thoughts on going on TRT while I do the CDNut's protocol?

My man....it makes ABSOLUTELY no sense to do the protocol while doing TRT. Completely works against what you'd be trying to do. The protocol, essentially is one big giant restart.

And to answer your question, people mention it, but it doesn't make sense to do, so that's why you don't see it.

[BBG]

But what are the thoughts on going on TRT while I do the CDNut's protocol?

How old are you? Do you have clinically low testosterone levels?

TRT is generally the last option. If you have your diet/exercise/sleep/stress all in check, and your testosterone is still low, TRT may be your only option.

[Crashed]

In a pfs state? You'll get mixed results but none of them will cure you. It just doesn't make sense to do the protocol and run TRT.

I'm understanding and expecting it won't cure me, but i'm hoping just for an increase in quality of life tbh. im hoping to do your protocol on TRT and see what happens. like the fasting, juicing, IF/, water fasting, paleo diet.

How old are you? Do you have clinically low testosterone levels?

TRT is generally the last option. If you have your diet/exercise/sleep/stress all in check, and your testosterone is still low, TRT may be your only option.

26, got my T checked throughout the years:
at the start it was below the range, then it became just low and im awaiting some more bloodwork to see if it qualifies as low still.

[BBG]

Minoxidil inhibits androgen receptors and also decreases expression of 5-alpha reductase II

Minoxidil may suppress androgen receptor-related functions

Minoxidil Acts as an Antiandrogen: A Study of 5α-reductase Type 2 Gene Expression in a Human Keratinocyte Cell Line - PubMed

We can play the linking studies game all day if we want to:

Minoxidil INCREASES 5 alpha-reductase activity of cultured human dermal papilla cells from balding scalp

Topical minoxidil does not act as an antiandrogen in the flank organ of the golden Syrian hamster

As one of the studies above mentions, many NOW believe the mechanism of action for Minoxidil to be its prostaglandin activity (not its potential 5AR activity) that helps with hair loss:
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia

Activation of ... prostaglandin synthase-1 by minoxidil as a possible explanation for its hair growth-stimulating effect
And from this paper: Minoxidil: mechanisms of action on hair growth - PubMed

A number of in vitro effects of minoxidil have been described in monocultures of various skin and hair follicle cell types including stimulation of cell proliferation, inhibition of collagen synthesis, and stimulation of vascular endothelial growth factor and prostaglandin synthesis.

[Crashed]

We can play the linking studies game all day if we want to:

Minoxidil INCREASES 5 alpha-reductase activity of cultured human dermal papilla cells from balding scalp

Topical minoxidil does not act as an antiandrogen in the flank organ of the golden Syrian hamster

As one of the studies above mentions, many NOW believe the mechanism of action for Minoxidil to be its prostaglandin activity (not its potential 5AR activity) that helps with hair loss:
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia

Activation of ... prostaglandin synthase-1 by minoxidil as a possible explanation for its hair growth-stimulating effect
And from this paper: Minoxidil: mechanisms of action on hair growth - PubMed

A number of in vitro effects of minoxidil have been described in monocultures of various skin and hair follicle cell types including stimulation of cell proliferation, inhibition of collagen synthesis, and stimulation of vascular endothelial growth factor and prostaglandin synthesis.

Regardless there are many men who r sufering from 'pfs' just from minoxidil. https://www.askapatient.com/viewrati...+%28FOR+MEN%29

thats only dating back from 2020, theres far more people from 2015 but the old ones get pushed down. its really tragic

[BBG]

Regardless there are many men who r sufering from 'pfs' just from minoxidil. https://www.askapatient.com/viewrati...+%28FOR+MEN%29

thats only dating back from 2020, theres far more people from 2015 but the old ones get pushed down. its really tragic

My guess is that many of these users were also prescribed Finasteride and don't realize that Finasteride is the cause of their lasting effects.

For instance:

i wish i had not taken this drug. finasteride gave me side effects but i recovered with minox its been 3wks and no change. i used to watch prn everyday but now im afraid because its difficult to have an erection. my only hope is my libido would return.

I had a similar issue with finasteride and sexual function, however after a week I was pretty much back to normal. No idea what's happened this time but im really scared that I've done damage for good this time.

Basically they stopped finasteride, but continued on minoxidil, and now attribute their long lasting PFS symptoms to minoxidil.

[Crashed]

My guess is that many of these users were also prescribed Finasteride and don't realize that Finasteride is the cause of their lasting effects.

For instance:





Basically they stopped finasteride, but continued on minoxidil, and now attribute their long lasting PFS symptoms to minoxidil.

Well i never have taken finastride in my life so that theory doesnt hold up and so have many other dudes ive spoken to who have crashed from minox

[BBG]

Well i never have taken finastride in my life so that theory doesnt hold up and so have many other dudes ive spoken to who have crashed from minox

I should clarify, I'm not saying minoxidil cannot be the cause of adverse reactions in users. I'm saying that the effects of minoxidil are almost certainly not being caused for the same reasons as Finasteride (IE, 5ar reduction).

Take the case study: TOPICAL MINOXIDIL 5% INDUCED MALE SEXUAL DYSFUNCTION

The arteriolar vasodilation induced by minoxidil activates the peripheral sympathetic nervous system (SNS) via carotid and aortic baroreceptor reflexes. In tandem with activation of the SNS, both the pulse rate and cardiac output increase (11,12). Minoxidil administration evokes an increase in plasma renin activity, largely due to activation of the SNS (13-15). The activation of the renin-angiotensin axis elicits an increase in plasma and urinary aldosterone levels (13-15). As well as, minoxidil possesses alpha-adrenoceptor agonist activity in addition to potassium-channel opening activity (16). As a part of erection biology, the peripheral nervous system helps transmit the central impulses to the end organ. Sympathetic pathways generally provide inhibitory impulses, whereas parasympathetic and somatic innervation is
pro-erectogenic, the most important component responsible for penile erection is the corpus cavernosum; smooth muscle relaxation within this tissue is the endpoint of all stimuli resulting in an erection, Alpha-adrenergic agents induce smooth muscle contraction and result in DE tumescence (17). Antagonism of alpha-adrenergic signaling
enables other independent relaxatory pathways to predominate within the penile trabecular smooth muscle (18). Allergic dermatitis which manifested by the patient as itchy and burning scalp, which is seen on examination as an erythematous and scratched scalp, leads to increase in absorption of topical minoxidil systematically. This increase
in absorption leads to low blood pressure values manifested as dizziness. Because of arteriolar vasodilatation caused by absorbed minoxidil and the direct adrenergic effect of minoxidil; sympathetic system activated. Sympathetic system activation flagged by chest tightness and racing heart also led to corpus cavernosum smooth muscle
contraction and result in DE tumescence. In the patient reported here, the absence of organic and psychological cause of erectile dysfunction, and the indirect effect on minoxidil.

Of course, for this patient, when he stopped minoxidil, the issues went away.

[Cdsnuts]

Regardless there are many men who r sufering from 'pfs' just from minoxidil. https://www.askapatient.com/viewrati...+%28FOR+MEN%29

thats only dating back from 2020, theres far more people from 2015 but the old ones get pushed down. its really tragic

You’re right….we can play the linking studies game all day long, so what’s the point? You linked to studies saying one thing and he listed studies saying the complete opposite.

Bottom line is, Minoxidil can create pfs symptoms in certain men. Many of them are here fixing themselves.

I’m not sure why you’re arguing with them? These guys are not making this up. Their lives are ruined for the moment which is why they’re here
The last thing they need is to be told what they are going through isn’t real…..they’ve had enough of that from the medical community.

I appreciate the help, but this section is a bit different then the other sections on this forum. I’ve been running this subsection for almost five years and have seen and (helped fix) it all.

I know you have vast knowledge when it comes to gear and products of that nature. I have vast knowledge about pfs and pfs like conditions. It’s what I’ve been doing for almost a decade.

The medical community in this regards is useless, which is why their “studies” are useless as well. You can pick out any study and sure as shit you can find another scientific study contradicting the first.